A5033785062- Adrenal and Paraganglionic Tumors
- Neuroendocrine Tumor Research Advances
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Gastric Cancer Management and Outcomes
- Neuroblastoma Research and Treatments
- Glioma Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Cardiac tumors and thrombi
- Soft tissue tumors and treatment
- Uterine Myomas and Treatments
- Metastasis and carcinoma case studies
- Pituitary Gland Disorders and Treatments
- Gastrointestinal disorders and treatments
- PI3K/AKT/mTOR signaling in cancer
- Virus-based gene therapy research
- Cancer Research and Treatments
- Gastrointestinal Tumor Research and Treatment
- CAR-T cell therapy research
- Soft tissue tumor case studies
- Metal and Thin Film Mechanics
- Sexual Differentiation and Disorders
Ministry of Health of the Russian Federation
2019-2024
Pirogov Russian National Research Medical University
2022
Russian Cancer Research Center NN Blokhin
2016
Faculdades Guarulhos
2016
A 37-year-old patient presented with recurring episodes of weakness and dizziness, including loss consciousness, for over 2 years prior to presentation. She denied any gynecologic symptoms reported a normal menstrual cycle. medical history. Her past surgical history was
Background. Adrenocortical cancer (ACC) is a rare malignancy of the adrenal cortex. Therapeutic options for advanced ACC are limited. It necessary to study new and more effective drug combinations tumor biological targets. The purpose was determine expression somatostatin receptor subtypes 2A (SSTR SSTR 5) using immunohistochemical (IHC) analysis tissue samples in patients with ACC, as well feasibility prolonged analogues treatment ACC. Material methods. 5 analyzed imunohistochemistry from...
Neuroendocrine tumors (NETs) of the stomach include a wide range neoplasm with different variants disease, various approaches to treatment and prognosis. The incidence is quite low - NETs accounted for only 9% all gastrointestinal (GI) 0,3% stomach. Gastric have significantly biological clinical characteristics from other carcinoids developing “foregut”. distinctive features these attract attention many scientists. Modern methods instrumental diagnostics, as well histological,...
Introduction : Pheochromocytoma (PC) and paraganglioma (PG) are rare neuroendocrine tumors derived from adrenal chromaffin cells. The main options of systemic therapy for PC / PG alkylating agent-based chemotherapy (ChT) targeted with sunitinib. There no comparative data on the efficacy these options, which became purpose this study. Materials methods This retrospective single-center study included patients over 18 y. o. who received ChT or first line treatment metastatic September 2015 to...
Адренокортикальный рак (АКР) имеет высокий злокачественный потенциал в преобладающем большинстве случаев, однако у некоторых больных АКР характеризуется вялым, неагрессивным течением, когда пациенты с доказанными отдаленными метастазами или рецидивом могут жить без прогрессирования достаточно продолжительное время. Индолентный курс определен как отсутствие роста доказанных злокачественных опухолевых узлов за период 12 мес. и более. Проведен сравнительный анализ клинико-морфологических...
Background : Adrenocortical carcinoma (ACC) is a rare and aggressive disease. There are only few studies evaluating the diagnostic value of gas chromatography-mass spectrometry (GC-MS) for detection ACC recurrence after surgery. It necessary to conduct an in-depth study search most informative markers disease relapse. Aim To urine steroid metabolism by GC-MS during treatment identify early signs metastatic Materials methods Thirty nine (39) patients were examined before surgery, in...
Viral oncolysis, an approach to cancer therapy that emerged in the XX century and based on natural ability of viruses kill (lyse) cells which it multiplies, has been developed recent years by identifying or their engineering variants with selective tumor replication. Over past decades, a number specific interactions oncolytic (both RNA IDNA-containing) malignant have described, individual candidate types tumors they lase detected. The therapeutic efficacy is achieved through combination...
Gastrointestinal neuroendocrine tumors (GI-NETs) include a wide range of with different variants the course disease. At one end clinical spectrum there are highly differentiated type I GI-NETs, five-year survival rate over 95%, at another low-differentiated carcinoma (large-, smallcell cancers) representing tumor extremely poor prognosis. Therapeutic approaches to types different. It is necessary distinguish treatment well-differentiated neoplasms (I and II clinical-morphological type)...
Adrenocortical cancer is an orphan tumor with poor prognosis. The combination of EDP chemotherapy regimen and mitotane the standard for first‑line therapy. But there are no effective options second consequent lines second‑line therapy gemcitabine, capecitabine mitotane, which provides objective response in 4–7 % patients. Achievement therapeutic concentration most important predictive factor efficiency GemCap + regimen, and, therefore, it recommended to continue after progression mitotane....
Background: Prolonged episodes of uncontrolled congenital adrenal hyperplasia (CAH) have been shown to result in the occurrence secondary neoplasms. Prevalence incidentalomas patients with 21-hydroxylase deficiency ranges from 11% 82%. As assessed by gas chromatography-mass spectrometry (GC-MS), adrenocortical cancer (ACC) increased level steroid hormone precursors due decreased activity steroidogenesis enzymes, mainly that and 11-hydroxylase. It seems relevant compare specific...
The combination of platinum-based chemotherapy with mitotane (m) is the standard first-line therapy for metastatic adrenocortical cancer (ACC) long-term disease control in approximately 25% patients.Considering lack effective regimens second and subsequent lines therapy, it seems relevant to evaluate effectiveness re-induction patients long platinum-free interval.Aim:Evaluation efficiency or without ACC.Materials methods:This retrospective clinical study included progression ≥ 6 months after...
КЛИНИЧЕСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ ХИРУРГИЯИнтракардиальный внутривенный лейомиоматоз -редкое заболевание, характеризующееся прежде всего наличием мезенхимальной опухоли в матке, которая по своим морфологическим признакам не противоречит лейомиоме, но обладает способностью прорастать просветы вен.Распространяясь внутренним подвздошным или яичниковым венам, она может достигать нижней полой вены и правых камер сердца, приводя к серьезным функциональным нарушениям сердечной...
Neuroendocrine neoplasms (NEN) of the stomach include a heterogeneous group characterized by different pathogenetic mechanisms, metastatic potential, and prognosis. The incidence gastric NAN has increased 15-fold over past few decades. It is necessary to clearly distinguish between well-differentiated neuroendocrine (NETs) cancer (NECs) stomach, as well mixed neuroendocrine-non-neuroendocrine neoplasms. To date, there are three classifications that used in clinical practice:...