A5034726881- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Sarcoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cardiac tumors and thrombi
- Esophageal Cancer Research and Treatment
- Neuroendocrine Tumor Research Advances
- Adrenal and Paraganglionic Tumors
- Helicobacter pylori-related gastroenterology studies
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Vascular Tumors and Angiosarcomas
- Colorectal Cancer Treatments and Studies
- Esophageal and GI Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Cells and Metastasis
- Ovarian cancer diagnosis and treatment
- Galectins and Cancer Biology
- Pancreatic and Hepatic Oncology Research
- Circular RNAs in diseases
- Neuroblastoma Research and Treatments
- Hormonal Regulation and Hypertension
- Renal cell carcinoma treatment
Ministry of Health of the Russian Federation
2016-2025
Pirogov Russian National Research Medical University
2019-2025
Ministry of Health
2021-2024
Russian Cancer Research Center NN Blokhin
2011-2023
Russian Medical Academy of Continuous Professional Education
2016-2022
Advanced Radiation Therapy (United States)
2020
Sechenov University
2020
Marymount University
2020
National Medical Research Center of Cardiology
2020
Russian Academy of Sciences
2008
389 Background: GC is a heterogeneous disease with range of molecular subtypes. The TCGA (Cancer Genome Atlas) and ARCG (Asian Cancer Research Group) classified tumors MSI status as specific group. Programmed cell death receptor 1 (PD-1) its ligand (PD-L1) are playing progressively important role in tumor immunology cancer treatment. present study investigated the relationship between PD-L1 expression. Methods: We analyzed patients who received treatment from September 2019 to March 2023 at...
Our work aimed to differentiate 20 aberrantly methylated miRNA genes that participate at different stages of development and metastasis ovarian carcinoma (OvCa) using methylation-specific qPCR in a representative set clinical samples: 102 primary tumors without with metastases (to lymph nodes, peritoneum, or distant organs) 30 peritoneal macroscopic (PMM). Thirteen (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, MIR9-3) were...
Despite the use of modern treatment methods for gastric cancer (GC), survival rates in locally advanced stages remain unsatisfactory. This necessitates search new therapeutic options and potential predictive factors tailoring approaches. The emergence molecular classifications like Cancer Genome Atlas (TCGA) Asian Research Group (ACRG), leading to identification a distinct subset — with high microsatellite instability (MSI-H) caused by mismatch repair deficiency (dMMR), has paved way novel...
357 Background: Signet ring cell (SRC) gastric cancer (GC) has its unique clinicopathological features with poor tissue differentiation, high invasiveness, diffuse growth pattern and prognosis. Survival rates characteristics of patients SRC GC regardless the stage disease not been well studied. Methods: The retrospective analysis was undertaken 993 diagnosed cancer. These received surgical resection in period from January 2013 to December 2018 N.N. Blokhin National Medical Research Center...
Background/Objectives: Immune checkpoint inhibitors targeting the PD-1/PD-L1 pathway have revolutionized cancer immunotherapy, however clinical relevance of their soluble forms (sPD-1 and sPD-L1) remains less studied. Soluble PD-1 PD-L1 been implicated in tumor progression, prognosis, treatment response across various malignancies. This study aims to provide a comprehensive analysis sPD-1 sPD-L1 levels serum diverse types, including rare malignancies, evaluate associations with...
Background: Cadherins are calcium-dependent transmembrane glycoproteins whose extracellular domains mediate homophilic intercellular interactions. Their soluble forms (s-cadherins), generated through proteolytic cleavage of proteins or alternative mRNA splicing, not anchored in the cell membrane and circulate space peripheral blood. In context carcinogenesis, role P-cadherin remains a matter debate: some studies associate with tumor growth suppression, while others indicate its...
Sequential courses of anticancer target therapy lead to selection drug-resistant cells, which results in continuous decrease clinical response. Here we present a new approach for predicting effective combinations drugs, act synergistic manner. Synergistic drugs may prevent or postpone acquired resistance, thus increasing treatment efficiency. We cultured human ovarian carcinoma SKOV-3 and neuroblastoma NGP-127 cancer cell lines the presence Tyrosine Kinase Inhibitors (Pazopanib, Sorafenib,...
The article presents an analysis of the dynamics incidence malignant tumors (MT) and mortality from them. An attempt has been made to analyze causes growth or decrease in morbidity some forms MT. Based on domestic international experience suggestions planning measures further reduce MT Russian Federation were made. Mortality Russia reduces mainly by decreasing lung cancer other cancer, cause which is smoking, as well stomach cancer. Primary prevention plays a dominant role this decline....
The identification of new prognostic markers renal cell carcinoma (RCC) is an urgent problem in oncourology. To investigate the potential significance tumor microbiome and stromal inflammatory markers, we studied a cohort 66 patients with RCC (23 clear RCC, 19 papillary 24 chromophobe RCC). was analyzed normal tissue by 16S rRNA amplicon sequencing. Characterization stroma performed using immunohistochemistry. A significant difference alpha diversity demonstrated between kidney all types...
The locally advanced esophageal carcinoma can be complicated by fistulas. According to published data, the incidence rate of malignant fistulas is about 13%. range treatment modalities proposed different authors varies from palliation active and, if possible, radical surgical interventions. In present study, we investigated combined esophagectomies as a fistulas.Thirty-five patients (aged 28--67) with localizations were operated over period 1990 2000. tumor was located in upper, middle and...
Objective: To examine the efficacy of Ivor Lewis esophagectomy with extended 2-field lymph node dissection for thoracic esophageal carcinoma we reviewed our experience. Methods: We analyzed cases 147 consecutive patients who underwent subtotal through approach cancer from January 1996 December 2000. Eighty-six were operated on midthoracic esophagus, 48 lower and 13 aortal segment esophagus. No patient had received chemotherapy or radiotherapy before operation. Results: There 113 men (76.9%)...
In the immunotherapy based on immune checkpoint inhibition (IC), additional ICs are being studied to increase its effectiveness. An almost unstudied feature is possible co-expression of ICs, which can determine therapeutic efficacy their inhibition. For selection promising information association expression with cancer development may be essential. We have obtained data correlation ADAM17, PVR, TDO2, CD274, CD276, CEACAM1, IDO1, LGALS3, LGALS9, and HHLA2 genes in gastric (GC). All but one,...
Statement of hormonal activity and potential malignancy are the most important issues diagnosis selection appropriate treatment way for patients with adrenal tumors. Adrenal cortical carcinoma (ACC) is rare disease poor prognosis. Incidience ACC about 0.5-2 per million, no more then 2-4% among This draft guidelines offered to common discussion wide round specialists.
EVs are involved in local and distant intercellular communication play a vital role cancer development. Since have been found almost all body fluids, there currently active attempts for their application liquid diagnostics. Blood is the most commonly used source of screening markers, although percentage tumor-derived blood extremely low. In contrast, GJ, as biofluid, expected to be enriched with GC-associated EVs. However, from GJ never applied underinvestigated overall. Here we show that...
Background: Galectins are a family of β-galactoside binding proteins that regulate the vast majority cellular functions, including proliferation, migration, adhesion, and phagocytosis in both health disease. More more experimental clinical evidence indicates galectins involved many stages carcinogenesis, patients with renal cell carcinoma (RCC). Aim: To analyze significance soluble forms -1, -3, -4, -7, -9 various histological RCC types. Materials methods: We performed retrospective analysis...
Aim. To evaluate the efficacy and toxicity of second-line polychemotherapy according to FOLFOX or FOLFIRI regimen in patients with biliary tract tumours after progression during first-line chemotherapy (CT). Materials methods. The study is based on analysis retrospective prospective data examination treatment 94 cancer grades T1-4N0-2M0-1 followed-up treated at N.N. Blokhin National Medical Research Center Oncology from 2015 2023. All were divided into 2 groups: Group 1 (FOLFOX, n=47)...
A comprehensive analysis of the cell phenotype inflammatory infiltrate tumor stroma represents a promising area molecular oncology. The study not only soluble forms various immunoregulatory molecules, but also their membrane-bound is considered highly relevant. We performed tissue and circulating PD-1 PD-L1 proteins, as well macrophage B-cell markers in gastric cancer, to assess clinical prognostic significance. blood plasma samples from 63 cancer patients were studied using ELISA...
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Клиническая и прогностическая значимость sPD-1 sPD-L1 при раке яичников 1 Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр онкологии имени Н.Н.Блохина» Министерства