A5073831332- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer-related gene regulation
- RNA Research and Splicing
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Wnt/β-catenin signaling in development and cancer
- Ubiquitin and proteasome pathways
- High Altitude and Hypoxia
- Glutathione Transferases and Polymorphisms
- Nutrition, Genetics, and Disease
- Kruppel-like factors research
- Cancer, Hypoxia, and Metabolism
- Renal cell carcinoma treatment
- Genetic factors in colorectal cancer
- Cancer Cells and Metastasis
- Axon Guidance and Neuronal Signaling
- Gene expression and cancer classification
- Genomics and Chromatin Dynamics
- Genomic variations and chromosomal abnormalities
- Molecular Biology Techniques and Applications
- Muscle metabolism and nutrition
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences
2015-2024
Anti-Doping Laboratory
2021-2024
Lomonosov Moscow State University
2021-2024
Institute of Biochemical Physics NM Emanuel
2024
Moscow State University
2021-2023
Moscow Research Institute" Nemchinovka "
2021-2022
Marymount University
2019
Research Centre for Medical Genetics
2008-2017
Research Institute of Medical Genetics of Russian Academy of Medical Sciences
2015
Russian Academy of Sciences
2013
CHL1 gene (also known as CALL) on 3p26.3 encodes a one-pass trans-membrane cell adhesion molecule (CAM). Previously CAMs of this type, including L1, were shown to be involved in cancer growth and metastasis.We used Clontech Cancer Profiling Arrays (19 different types cancers, 395 samples) analyze expression the gene. The results further validated by RT-qPCR for breast, renal lung cancer. revealed differential gene: down-regulation/silencing majority primary tumors up-regulation associated...
This study aimed to clarify genetic and epigenetic alterations that occur during lung carcinogenesis design perspective sets of newly identified biomarkers. The original method includes chromosome 3 specific NotI-microarrays containing 180 NotI clones associated with genes for hybridization 40 paired normal/tumor DNA samples primary tumors: 28 squamous cell carcinomas (SCC) 12 adenocarcinomas (ADC). NotI-microarray data were confirmed by qPCR bisulfite sequencing analyses. Forty-four showed...
The SEMA3B gene is located in the 3p21.3 LUCA region, which frequently affected different types of cancer. objective our study was to expand knowledge as a tumor suppressor and mechanisms its inactivation. In this study, several experimental approaches were used: growth analyses apoptosis assays vitro SCID mice, expression methylation other. With use small cell lung cancer line U2020 we confirmed function suppressor, showed that suppression can be realized through induction and, possibly,...
Our work aimed to differentiate 20 aberrantly methylated miRNA genes that participate at different stages of development and metastasis ovarian carcinoma (OvCa) using methylation-specific qPCR in a representative set clinical samples: 102 primary tumors without with metastases (to lymph nodes, peritoneum, or distant organs) 30 peritoneal macroscopic (PMM). Thirteen (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, MIR9-3) were...
Haploid plants with a doubled set of chromosomes (doubled haploid (DH)) significantly speed up the selection process by fixation genetic traits in each locus homozygous state within one generation. Doubled haploids are mainly attained formation from cultured gametophytic (haploid) tissues and cells vitro, or targeted reduction parent chromosome during intra- interspecific hybridization. Since then, DH has become most powerful tools to support various basic research studies, as well applied...
Ovarian cancer (OC) is one of the most common types among malignancies female reproductive system. This pathology asymptomatic until advanced stages and has a poor prognosis. Our study aimed to search for lncRNA-miRNA-mRNA competing triplets that promote ovarian tumorigenesis. For this purpose, we analyzed tumor samples from TCGA database verified results experimentally in set 46 paired matched histologically unchanged tissues OC patients. The list RNAs selected silico experimental studies...