A5045320163- Renal cell carcinoma treatment
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Renal and related cancers
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- RNA Interference and Gene Delivery
- Nutrition, Genetics, and Disease
- Metastasis and carcinoma case studies
- BRCA gene mutations in cancer
- Radiopharmaceutical Chemistry and Applications
- Estrogen and related hormone effects
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Lung Cancer Research Studies
- Cancer-related Molecular Pathways
- CRISPR and Genetic Engineering
- Cancer Research and Treatments
- Lung Cancer Treatments and Mutations
- Animal Virus Infections Studies
Research Centre for Medical Genetics
2015-2023
Institute of Gene Biology
2019
Ministry of Health of the Russian Federation
2015
Academy of Medical Sciences
2007-2014
Research Institute of Medical Genetics of Russian Academy of Medical Sciences
1997-2005
Russian Academy of Sciences
2002
Our work aimed to differentiate 20 aberrantly methylated miRNA genes that participate at different stages of development and metastasis ovarian carcinoma (OvCa) using methylation-specific qPCR in a representative set clinical samples: 102 primary tumors without with metastases (to lymph nodes, peritoneum, or distant organs) 30 peritoneal macroscopic (PMM). Thirteen (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, MIR9-3) were...
The molecular prognostic markers of metastasis are important for personalized approaches to clear cell renal carcinoma (ccRCC) treatment but practical use still missing. To address this gap we studied the expression ten genes—CA9, NDUFA4L2, VWF, IGFBP3, BHLHE41, EGLN3, SAA1, CSF1R, C1QA, and FN1—through RT-PCR, in 56 ccRCC patients without metastases with metastases. All these, excluding showed differential increased (besides SAA1) non-metastasis tumors. gene levels tumors were decreased,...
In the immunotherapy based on immune checkpoint inhibition (IC), additional ICs are being studied to increase its effectiveness. An almost unstudied feature is possible co-expression of ICs, which can determine therapeutic efficacy their inhibition. For selection promising information association expression with cancer development may be essential. We have obtained data correlation ADAM17, PVR, TDO2, CD274, CD276, CEACAM1, IDO1, LGALS3, LGALS9, and HHLA2 genes in gastric (GC). All but one,...
Background. On the pace of growth in Russia, renal carcinoma takes 1st place. Approximately one third patients at time diagnosis have distant metastases, and relapse disease occurs 30–40 %. Renal does not manifest until later stage disease. More than 50 % cases is revealed occasionally. Therefore, development methods for quick efficient tumor actual. Materials methods. The level messenger RNA expression several genes was studied surgical material paired samples (normal tissue a malignant...
We aimed to identify and investigate genes that are essential for the development of clear cell renal carcinoma (ccRCC) sought shed light on mechanisms its progression create prognostic markers disease. used real-time PCR study expression 20 were preliminarily selected based their differential in ccRCC, 68 paired tumor/normal samples. Upon ccRCC progression, seven showed an initial increase decreased expression. The whose levels did not significantly change during associated mainly with...
Introduction . Clear cell renal carcinoma (ccRCC) is characterized by the high (30–40 % of cases) frequency lethal outcomes which at metastasis reaches 90 %. Lack efficient diagnostics early stages a disease indicates need searching on new ccRCC markers. Objective : for definition methylation role some tumor suppressor microRNA (miRNA) genes in pathogenesis and progression marker identification predictions. Materials methods. The alterations status 10 miRNA were determined specific...
In Russia, among tumors of the genitourinary system, renal cell carcinoma takes 2nd place after prostate cancer. 25 % patients at time diagnosis, metastases are detected. Treatment advanced stages is often not effective enough. The introduction into clinical practice modern immunotherapeutic drugs based on inhibition immune check points has changed prognosis disease for many with various malignant neoplasms, including kidney this article, we described results recent trials use immunotherapy...
Latent autoimmune diabetes of adults (LADA) is a variant mellitus. Its clinical feature not typical for classical DM1 despitethe presence positive autoantibodies characterized by the low rate destruction that accounts late development insulindependence. Similar to DM1, LADA associated with loss immune tolerance autoantibodies. However, quantitative andfunctional activity Treg as key regulators response and main agents remain poorly known their relationshipwith characteristics apoptosis.Aim....
Breast cancer is the 2nd most common malignant disease after lung cancer; about 1 in 8 women will develop breast her lifetime. Cancer progression a serious complication of that encourages comprehensive investigation molecular mechanisms underlying development. This also important for healthcare professionals involved patient management, since they have to choose an optimal treatment regimen. article discusses role microRNAs development cancer, their biogenesis, classification, association...