A5071847980- Gastric Cancer Management and Outcomes
- Head and Neck Cancer Studies
- Colorectal Cancer Treatments and Studies
- Metastasis and carcinoma case studies
- Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Helicobacter pylori-related gastroenterology studies
- Cancer Treatment and Pharmacology
- Head and Neck Surgical Oncology
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Research Studies
- Angiogenesis and VEGF in Cancer
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Surgical Treatments
- Multiple and Secondary Primary Cancers
- Oral Health Pathology and Treatment
- Fibroblast Growth Factor Research
- CAR-T cell therapy research
- Colorectal and Anal Carcinomas
- Salivary Gland Tumors Diagnosis and Treatment
- Circular RNAs in diseases
Ministry of Health of the Russian Federation
2019-2022
City Clinical Hospital
2019-2021
Russian Cancer Research Center NN Blokhin
2010-2017
Russian Academy of Sciences
2008
Academy of Medical Sciences
2008
Patients with head and neck squamous cell carcinoma diagnosed recurrent tumor or distant metastases usually have the worst prognosis. Chemotherapeutic options are very limited in these patients; there is a probability of drug resistance development. The researchers continue to search more effective less toxic drugs. In current article, we analyze results latest randomized clinical trials devoted assessment novel antitumor immunotherapeutic drugs – PD-1 inhibitors patients carcinoma. This...
Introduction. Patients are characterized by locally advanced tumors in 70–80 % of cases at presentation, so possibility cure and surgical treatment is limited. Total glossectomy, tongue base resection associated with severe permanent disability. Such procedures lead to dysphagia, alalia social maladjustment. Enumerated issues motivated us develop new method cancer. Objective introduce opportunities cancer the base. Materials methods . Glossectomy accomplished 5 patients suffering from...
The study objective is to investigate the causes of insufficient efficiency neck lymph node dissection and possibilities its improvement in cancer oral mucosa without clinically detectable metastases. Materials methods. A review literature on surgical methods affecting regional collectors cancers cavity was performed, preliminary data biopsy sentinel were obtained. Conclusion. Combination fluorescent mapping andflow cytometry allows identify detect hidden micrometastases with high sensitivity.
Objective of the study . Identification genes, expression which is associated with metastasis gastric cancer tumor. Materials and methods Quantitative real-time PCR on paired tumor – normal samples. Results An association VEGFR1, FGFR2 NRP-1 gene shown. The odds ratio (OR) was highest for gene: OR 175.00; 95 % CI 8.972–3413.271; VEGFR1 gene, 4.622, 1.240–17.227, NRP1 2.667; 0.597–11.915. When assessing jointly elevated 5,778; 1.393–23.909; p = 0.0147. frequency increased 5 in case...
The purpose of the study was a systemic literature review on data regarding efficacy, safety and prospects for use adjuvant chemotherapy locally advanced gastric cancer. Material Methods. contained thorough literary analysis results international studies preoperative postoperative Relevant sources were searched in Medlin Cochrane Library databases, publications from 2001 to 2019 included. Of all analyzed, 28 used write systematic review. Results . increase survival rates mainly achieved due...
Advances in understanding of the molecular mechanisms underlying oral squamous cell carcinoma (OSCC) have resulted an increasing number molecules-biomarkers that can be used for prediction behaviour this disease to achieve above objective. We identified and classified 24 biomarkers into five groups based on their biological functions: 1) cycle acceleration proliferation; 2) hypoxia-inducible factors; 3) tumour suppression apoptosis; 4) angiogenesis; 5) adhesion matrix degradation. considered...
e14567 Background: Role of second-line chemotherapy (CT) in metastatic gastric carcinoma is not defined yet. We launched this phase II trial to evaluate the efficacy and safety IRI/MMC combination patients (pts) with who failed first-line CT. Methods: Pts had progression after CT received MMC 8 mg/m2 i.v. day 1 + IRI 125 d 1, 8, 22, 29 every 6 weeks. Results: From 2005 2010, 40 pts were included study, 38 available for response. First-line 5-FU (38 pts), docetaxel (14 pts) cisplatin (31...
e15194 Background: Cisplatin and capecitabine docetaxel are active agents for treatment of metastatic gastric carcinoma. We underwent analysis efficacy toxicity douplet (CX ) triplet (DCX) regimens which were used in our department as a first-line chemotherapy patients with Methods: Pts carcinoma nonrandomly allocated to DCX regimen (docetaxel 75 mg/m 2 i.v. day 1, cisplatin 1650 per os days 1-14) or CX (cisplatin 2000 1-14 ). Up 6 cycles provided every 3 weeks. G-CSF was not routinely...
e14623 Background: Docetaxel is an active agent for treatment of metastatic gastric carcinoma. We launched this phase II trial to evaluate the efficacy and safety docetaxel, cisplatin capecitabine (DCX) combination in patients (pts) with Methods: Pts carcinoma received docetaxel 75 mg/m2 i.v. day 1, 1650 per os days 1-14 every 3 weeks. Up 6 cycles were provided. G-CSF was not routinely used primary prophylaxis. Results: From 2007 2011, 37 pts included study, all available response....
An analytical procedure has been developed for determining gemcitabine, the new drug with a broad spectrum of antitumor activity, in human plasma. The sample preparation drag assay involves precipitation plasma proteins mixture acetonitrile and methanol (9:1), followed by acidification glacial acetic acid. resulting supernatant is evaporated to dryness at 42°C under vacuum residue dissolved mobile phase consisting acetate buffer (pH 5.0) (97.5:2.5). Then, HPLC was carried out using...
The combination of ELF (etoposide, 5-fluorouracil, leucovorin) for metastatic gastric cancer is used since 1980-ies, but until recently, also often in modern chemotherapy cancer. In the arsenal anticancer combinations treatment there a number new modes with incorporation docetaxel, irinotecan, oxaliplatin and place unclear. our study, we analyzed 60 histories patients departments clinical pharmacology chemotherapy. We studied immediate long-term results their own group patients. All were...
Objective is the investigation of messenger RNA quantitative expression profiles potential target genes among disseminated gastric cancer cases. Materials and methods. Quantitative real-time polymerase chain reaction on paired tumor-normal samples. Results. The most frequently (25-41 % cases) an increased level in tumor with respect to normal tissue was observed for TGF-ß (transforming growth factor ß), NRP-1 (neuropiline 1) VEGF (vascular endothelial factor) family genes. For first time a...
This review is designed to discuss possibilities for the treatment of advanced gastric cancer with reference prognostic and predictive value molecular-biological parameters influence hereditary predisposition development neoplastic process. The data on modern pharmacotherapy this disease based knowledge are presented including following markers: HER2/neu, VGFR, c-met, TUBB3, CDH-1, BRCA-1, EGFR, TGF-ß, p53, Ki67 PCNA. It emphasized that role associated ambiguous. significance some markers...
In this literary review analyzed the possibilities of combination therapy in treatment locally advanced squamous cell carcinoma nasal cavity and paranasal sinuses, compares frequency nature side effects its different variants, assessed effectiveness intra-arterial chemotherapy comparison with other methods. Combined use systemic allows not carry out massive surgical operations, but does improve long-term results treatment. Regional has a number advantages: improves tumor response to...
Introduction . Chemoradiation therapy with a competitive regimen allows to avoid laryngectomy and increase patients’ quality of life. However, it’s highly toxic this limits the use approach in patients severe concomitant disorders. The alternative systemic chemotherapy is infusion high doses drugs directly into vessel supplying tumor through microcatheter. study objective present clinical case using intra-arterial for treatment locally advanced laryngopharyngeal cancer patient solitary...
The study objective is to report a case of successful treatment recurrent unresectable squamous cell carcinoma the head and neck using pembrolizumab (selective inhibitor, preventing interaction between programmed death receptor 1 (PD1) its ligands PD-L1 PD-L2). Materials metho ds. A 72-year-old male patient was admitted Clinic Head Neck Tumors, N.N. Blokhin Russian Cancer Research Center with following diagnosis: primary metachronous malignant tumors: 1) oropharyngeal cancer T2N3M0 (after...