A5020080254- Gastric Cancer Management and Outcomes
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Galectins and Cancer Biology
- Renal cell carcinoma treatment
- Helicobacter pylori-related gastroenterology studies
- Microbial metabolism and enzyme function
- Estrogen and related hormone effects
- Cancer and Skin Lesions
- Angiogenesis and VEGF in Cancer
- Soft tissue tumor case studies
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- RNA Interference and Gene Delivery
- Colorectal Cancer Treatments and Studies
- PI3K/AKT/mTOR signaling in cancer
- Fibroblast Growth Factor Research
- Metastasis and carcinoma case studies
- Inflammatory mediators and NSAID effects
- Soft tissue tumors and treatment
Research Centre for Medical Genetics
2017-2022
In the immunotherapy based on immune checkpoint inhibition (IC), additional ICs are being studied to increase its effectiveness. An almost unstudied feature is possible co-expression of ICs, which can determine therapeutic efficacy their inhibition. For selection promising information association expression with cancer development may be essential. We have obtained data correlation ADAM17, PVR, TDO2, CD274, CD276, CEACAM1, IDO1, LGALS3, LGALS9, and HHLA2 genes in gastric (GC). All but one,...
В настоящее время широкое распространение в клинической практике получили препараты, нацеленные на ингибирование иммунных контрольных точек (ИКТ). Однако для значительной группы больных монотерапия ингибитором ИКТ не является эффективной. Одна из причин этого кроется сложном механизме взаимодействия между рядом белков, являющихся рецепторами и лигандами разных ИКТ, которые одновременно присутствуют поверхности клетки. Одно решений этой проблемы — совместное подавление экспрессии нескольких...
Objective of the study . Identification genes, expression which is associated with metastasis gastric cancer tumor. Materials and methods Quantitative real-time PCR on paired tumor – normal samples. Results An association VEGFR1, FGFR2 NRP-1 gene shown. The odds ratio (OR) was highest for gene: OR 175.00; 95 % CI 8.972–3413.271; VEGFR1 gene, 4.622, 1.240–17.227, NRP1 2.667; 0.597–11.915. When assessing jointly elevated 5,778; 1.393–23.909; p = 0.0147. frequency increased 5 in case...
Рак желудка (РЖ) характеризуется агрессивным течением и является одной из ведущих причин смерти от онкологических заболеваний. Стандартные схемы лечения не всегда эффективны при этом заболевании, поэтому разработка новых подходов терапии поиск предиктивных маркеров представляется актуальной научной задачей. Перспективными терапевтическими мишенями злокачественных новообразованиях являются иммунные контрольные точки (ИКТ). Для понимания патогенеза оптимизации активно исследуется вклад ИКТ в...
Objective is the investigation of messenger RNA quantitative expression profiles potential target genes among disseminated gastric cancer cases. Materials and methods. Quantitative real-time polymerase chain reaction on paired tumor-normal samples. Results. The most frequently (25-41 % cases) an increased level in tumor with respect to normal tissue was observed for TGF-ß (transforming growth factor ß), NRP-1 (neuropiline 1) VEGF (vascular endothelial factor) family genes. For first time a...
This review is designed to discuss possibilities for the treatment of advanced gastric cancer with reference prognostic and predictive value molecular-biological parameters influence hereditary predisposition development neoplastic process. The data on modern pharmacotherapy this disease based knowledge are presented including following markers: HER2/neu, VGFR, c-met, TUBB3, CDH-1, BRCA-1, EGFR, TGF-ß, p53, Ki67 PCNA. It emphasized that role associated ambiguous. significance some markers...
Understanding the molecular genetic features of gastric cancer (GC) and principally functioning signaling cascades involved in its occurrence development is determining for identifying most promising genes targeted therapy. On this basis, consequent implementation effective drugs treatment regimens conducted. The inductors paths, main one which mTOR pathway, pathway are considered details. (angiogenesis factors, epidermal growth factor their receptors) actively studied as therapeutic...
Desmoid-type fibromatosis (DF) is a rare mesenchymal tumor occurring in only 2 to 4 people per 1,000,000 population year. Desmoid tumors are either seen sporadically or individuals with familial adenomatous polyposis (FAP). The etiology of sporadic DF uncertain. aim this study was estimate the potential significance germline mutations APC gene patients DF. exons were amplified, studied using conformation sensitive gel electrophoresis and then Sanger-sequenced. obtained data processed...
Были изучены уровни экспрессии miR-146а и гена-мишени этой микроРНК - NF-kB в образцах рака желудка (РЖ) на разных этапах развития метастазов. Экспрессия РЖ понижалась по мере вовлечения регионарных лимфоузлов метастатический процесс. Была обнаружена отрицательная корреляция уровня со степенью поражения (коэффициент корреляции Спирмену (R) составил R = 0,61; p=0,005). Напротив, экспрессия повышалась при поражении метастазами. Обнаружена обратная между miR-146a (R -0,76; p=0,03). Впервые...
The most serious complication of breast cancer (BC), which affects life expectancy, is metastasis the tumor. Metastasis cause more than 80% all deaths. After surgical treatment and use adjuvant therapy, metastases occur in 8% 15% cases. This indicates need to develop markers for prognosis clarify its mechanisms creation anti-metastatic therapeutic agents. In this paper, we studied association LOX uPAR gene expression with lymph nodes.
 Gene was measured using real-time PCR 40 paired...
Background . Metastasing and degree of differentiation refer to the main clinical characteristics malignant tumors. Both listed features need an in-depth study that can lead understanding mechanisms for occurrence certain state cancer cells. Objective Studying processes metastasis clear cell renal carcinoma (ccRCC) on gene expression. Materials methods The levels expression ten genes in 65 paired samples were studied (ccRCC tumor tissue normal kidney tissue) by real-time polymerase chain...