A5019689881- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Livestock and Poultry Management
- Animal Virus Infections Studies
- RNA Interference and Gene Delivery
- Gastric Cancer Management and Outcomes
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Freezing and Crystallization Processes
- Neuroendocrine Tumor Research Advances
- Virus-based gene therapy research
- Minerals Flotation and Separation Techniques
- Ferroptosis and cancer prognosis
- Glutathione Transferases and Polymorphisms
- Renal and related cancers
- Lung Cancer Research Studies
- Nanoparticle-Based Drug Delivery
- MicroRNA in disease regulation
- CAR-T cell therapy research
- Cancer Mechanisms and Therapy
- Circular RNAs in diseases
- Systemic Sclerosis and Related Diseases
- Immune cells in cancer
Research Centre for Medical Genetics
2018-2024
Vavilov Institute of General Genetics
2017
Russian Academy of Sciences
2015
We aimed to identify and investigate genes that are essential for the development of clear cell renal carcinoma (ccRCC) sought shed light on mechanisms its progression create prognostic markers disease. used real-time PCR study expression 20 were preliminarily selected based their differential in ccRCC, 68 paired tumor/normal samples. Upon ccRCC progression, seven showed an initial increase decreased expression. The whose levels did not significantly change during associated mainly with...
Introduction. Cardiovascular disease (CVD) remain the leading cause of death in industrialized countries. Patients with coronary heart (CHD) combination diabetes mellitus type 2 (T2DM) are characterized by more severe CHD and poor prognosis. Resent data indicate microRNAs (miRNAs) as important participants pathogenesis various pathological conditions, including obesity, T2DM CVD.The aim this study was to determine expression miRNAs associated development CHD, transforming growth factor beta...
Background. The tumor microenvironment can both restrain growth and promote disease progression. Therefore, the study of tumor-infiltrating lymphocytes (TILs) subpopulation composition is an urgent significant topic. Aim. To characterize immune renal cancer by flow cytometry. Materials methods. included blood, kidney normal tissue removed 32 patients with clear cell treated at N. Blokhin National Medical Research Center Oncology. Kidney was obtained during surgical removal (resection /...
Gastric cancer (GC) takes 5th place among the malignant neoplasms by incidence in world. Mortality from GC is high, since most cases disease diagnosed late stages, with distant metastases, five-year survival does not exceed 25–30 %. The standard for therapy surgery chemotherapy. There a high resistance to chemotherapy stages of GC, and this circumstance requires fundamentally new therapy. Recently, studies have been actively conducted on immune control point inhibitors. At moment, studied...
Background. The introduction of immunotherapy based on immune checkpoint inhibitors has significantly improve the effectiveness kidney cancer treatment. Nevertheless, not all patients respond to such treatment and there are no reliable predictive markers. Therefore, development a model system for assessing cellular response tumor seems be an urgent task. Aim. Development assess T-cell was focus this study. Materials methods. Primary cell culture peripheral blood fraction were obtained under...
The review summarizes data on the features of antigen presentation in tumor cells. molecular mechanisms antitumor immune response are considered with an emphasis ability cells to avoid action surveillance. expression MHC molecules depending treatment regimens provided. Ways improve existing and create new aimed at elimination because discussed.В обзоре собраны сведения об особенностях презентации антигена в опухолевых клетках. Рассмотрены молекулярные механизмы, регулирующие...