A5046348536- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Radiomics and Machine Learning in Medical Imaging
- Urologic and reproductive health conditions
- Radiopharmaceutical Chemistry and Applications
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Renal and related cancers
- Advanced X-ray and CT Imaging
- Pain Management and Opioid Use
- Medical History and Innovations
- Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Urinary and Genital Oncology Studies
- CRISPR and Genetic Engineering
- Neuroblastoma Research and Treatments
- Genital Health and Disease
- Neuroendocrine Tumor Research Advances
- Cardiac Imaging and Diagnostics
- Colorectal Cancer Surgical Treatments
- Anatomy and Medical Technology
- History of Medical Practice
- Health Systems, Economic Evaluations, Quality of Life
Cancer Research Center
2014-2020
Ministry of Health of the Russian Federation
2018-2019
European Hospital
2017-2018
Russian Medical Academy of Continuous Professional Education
2018
Russian Cancer Research Center NN Blokhin
2015-2018
Pirogov Russian National Research Medical University
2018
Background. New potential biomarker for patients with metastatic hormone-naive prostate cancer (PCa) might be detection of programmed death ligand 1 (PD-L1) expression in tumor which is associated worsened results treatment and decreased survival pancreatic cancer, lung other malignant tumors. Objective : to evaluate the prognostic value positive PD-L1 status on time castration resistance (CRPCa) metastatic PCa receiving hormonal androgen deprivation therapy first-line systemic treatment....
Background. On the pace of growth in Russia, renal carcinoma takes 1st place. Approximately one third patients at time diagnosis have distant metastases, and relapse disease occurs 30–40 %. Renal does not manifest until later stage disease. More than 50 % cases is revealed occasionally. Therefore, development methods for quick efficient tumor actual. Materials methods. The level messenger RNA expression several genes was studied surgical material paired samples (normal tissue a malignant...
Контакты: Гюля
Итоги обсуждения вопросов лечения метастатического кастрационно-резистентного рака предстательной железы (мКРРПЖ) и определения места препарата энзалутамид в лечении пациентов с мКРРПЖ.
Objective: to estimate overall survival (OS) rates in patients with metastatic castration-resistant prostate cancer (mCRPC), who have received currently available drugs and identify the predictors of OS. Subjects methods. The case histories 112 mCRPC treated at N.N. Blokhin Russian Cancer Research Center 2005 2014 were retrospectively analyzed. All had standard regimens based on docetaxel, cabazitaxel, abiraterone acetate combination prednisolone. Results. Whatever treatment option was,...
The problem of timely diagnosis and malignancy grade evaluation prostate cancer is especially urgent considering continuous progredient increase in morbidity mortality caused by this nosology, as well difficulty diagnostics. conducted literature review shows that currently magnetic resonance imaging (MRI) the leading method for diagnostics grading primary cancer, local metastases, distant identification recurrences prostatic fossa after radical prostatectomy. Sensitivity specificity MRI are...
The efficiency of prostate cancer (PC) diagnosis using multipatametric magnetic resonance imaging (MRI) was evaluated. Unlike most investigations the similar problem, this trial provides an objective assessment applying method statistical analysis - binary logistic regression. It used data on 166 patients, including primary patients (with suspected PC), as well with established PC, those a history negative biopsy, and recurrent PC. Some underwent target results which were then employed for...
Introduction. Standard prostate biopsy with subsequent histological verification is now an integral part of the diagnosis cancer (PC); however, number false-negative results and cases underestimation degree tumor aggressiveness remain excessively high. The active massive clinical introduction multiparametric magnetic resonance imaging (mpMRI) in combination hybrid technologies, such as MRI/ultrasound fusion biopsy, can significantly increase detection rate moderate- high-risk cancers....
On January 1, 2018, an updated 8 th edition of the international TNM Classification Malignant Tumors comes into effect. The classification was developed by 2 leading organizations: American Joint Committee on Cancer (AJCC) and Union for International Control (UICC). Based consensus conferences Society Urological Pathology (ISUP) which reconsidered current approaches to pathomorphology staging malignant tumors prostate (2009), kidneys (2012), testicles penis (2015), World Health Organization...
Background . Clear cell renal carcinoma is the most frequent and aggressive kidney cancer. Approximately 30 % at initial diagnosis reveal distant metastases. This due to fact that cancer in early stages asymptomatic. Very often (about 50 %), detected by chance, during a routine examination or treatment for other reasons. In this regard, development of new methods clear actual. Materials The levels mRNA expression methylation number genes surgical material paired samples (normal tissue tumor,...
The study aimed to analyze the diagnostic performance of preoperative multiparametric magnetic resonance imaging (mp-MRI) in staging prostate cancer (PCa) versus postoperative histological examination and determine most sensitive pulse sequence from mp-MRI protocol estimating local extent PCa.The comprised 112 men aged 52 84 years with a morphologically verified diagnosis cancer. All patients underwent pelvic before radical prostatectomy (RPE) no earlier than six weeks after biopsy. Radical...
Oncology statistics shows steady increase of prostate cancer, since early diagnosis and adequate treatment are crucial. Among imaging modalities sonoelastography (SEG) has a special value for identifying suspicious dense foci in prostate, however more studies still required to establishing accuracy specificity with different SEG techniques updating the cancer diagnostics protocol.The aim study was evaluate capabilities ultrasound guided biopsy, comparing gray scale Doppler modalities. 512...
The European Society for Medical Oncology (ESMO) Congress in partnership with the Association Cancer Research took place between September 8th and 12th of 2017 Madrid. In 42 years its existence, forum has grown from a regional educational meeting Europe to main international event oncology. key topic this was integration molecular biology knowledge clinical specialties. ESMO united almost 24,000 professionals various fields 131 countries who submitted 1736 abstracts. More than 50 scientific...
The 54 th American Society of Clinical Oncology (ASCO) Annual Meeting took place between 1 st and 5 June in Chicago (USA) united more than 40,700 professionals various fields. Oncological urology topics account for a considerable proportion the proceedings. In this article, review most significant reports on cancer from ASCO 2018 is presented.
Fluorescence in situ hybridization is a current technique to detect chromosomal specific genetic disorders urinary bladder cancer (UBC). This may be used diagnose UBC, follow up patients after surgical treatment, evaluate the efficiency of adjuvant therapy these patients, and predict development disease recurrence.
Prostatic stromal tumor (PST) of uncertain malignant potential belongs to a group rare tumors. The etiology, pathogenesis, and risk factors this are unknown. Up now, there have been less than 100 reports PST in the literature. major complaints patients with include difficult urination or defecation, blood urine semen. paper describes case Patient I. aged 22 years who underwent removal at Department Urology, N.N. Blokhin Russian Cancer Research Center, Academy Medical Sciences, on December...
Neuroendocrine carcinoma of the prostate belongs to so-called small-cell neuroendocrine carcinomas and amounts 1–2 % all malignancies. With allowance made for low incidence this pathology, paper describes a case high-grade (small-cell) cancer with an aggressive course.
Introduction . Oncological and palliative patients undergo treatment causing adverse events including mental cognitive disorders leading to their inability express wishes in the legal sense. This affects possibility of preparation documents on disposal property: wills, donation or sale purchase agreements, letters authorization. Aim To consider problems arising when an oncological patient decides dispose property suggest solutions these problems. Materials methods. An analysis current...
This literature review provides information on the main radiation diagnostic methods and approaches for prostate cancer, which are used in current medical practice both by ultrasound (routine transrectal (TRUS), sonoelastography, etc.) most promising techniques (multiparametric magnetic resonance imaging (mpMRI), hybrid fluorocholine GaPSMA positron emission tomography/computed tomography Ga-PSMA, etc.), widespread clinical introduction of has been recently observed. The paper discusses...