A5066378114- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Galectins and Cancer Biology
- Radiopharmaceutical Chemistry and Applications
- Immune Cell Function and Interaction
- Protein Tyrosine Phosphatases
- Colorectal Cancer Treatments and Studies
- Monoclonal and Polyclonal Antibodies Research
- Ovarian cancer diagnosis and treatment
- Neuropeptides and Animal Physiology
- Renal cell carcinoma treatment
- 3D Printing in Biomedical Research
- Lipid metabolism and disorders
- Glycosylation and Glycoproteins Research
- Macrophage Migration Inhibitory Factor
- Cell Adhesion Molecules Research
- Bladder and Urothelial Cancer Treatments
- Boron Compounds in Chemistry
- Signaling Pathways in Disease
- Gastric Cancer Management and Outcomes
- Plant Reproductive Biology
- Peptidase Inhibition and Analysis
- Mathematical Biology Tumor Growth
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
Ministry of Health of the Russian Federation
2020-2025
Moscow State University of Medicine and Dentistry
2022-2023
Background/Objectives: Immune checkpoint inhibitors targeting the PD-1/PD-L1 pathway have revolutionized cancer immunotherapy, however clinical relevance of their soluble forms (sPD-1 and sPD-L1) remains less studied. Soluble PD-1 PD-L1 been implicated in tumor progression, prognosis, treatment response across various malignancies. This study aims to provide a comprehensive analysis sPD-1 sPD-L1 levels serum diverse types, including rare malignancies, evaluate associations with...
Background: Galectins are a family of β-galactoside binding proteins that regulate the vast majority cellular functions, including proliferation, migration, adhesion, and phagocytosis in both health disease. More more experimental clinical evidence indicates galectins involved many stages carcinogenesis, patients with renal cell carcinoma (RCC). Aim: To analyze significance soluble forms -1, -3, -4, -7, -9 various histological RCC types. Materials methods: We performed retrospective analysis...
Клиническая и прогностическая значимость sPD-1 sPD-L1 при раке яичников 1 Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр онкологии имени Н.Н.Блохина» Министерства
Results of ELISA investigation the pretreatment sPD-1 and sPD-L1 content in blood serum 133 bone neoplasms patients aged 6-70 years 57 practically healthy control persons 12-70 are described. In 14 were a benign character, 16 - borderline giant-cell tumor was diagnosed, 103 malignant lesions including 39 osteosarcomas 42 chondrosarcomas revealed. The receptor concentrations did not differ between primary patients, while level statistically significantly increased (p<0.0000001). By means...
Background. The most important problems in improvement of treatment outcomes patients with renal cell carcinoma (RCC) are search and validation molecular markers for its early diagnosis prognosis. Genes suppressing distant metastasizing but not affecting the primary tumor called metastasis suppressors. Study these genes their products only improves understanding mechanisms progression, has practical value diagnosis, prognosis, establishment new targets antitumor therapy. One such is KISS1...
Blood serum of patients with gastric (n = 68) and esophageal 43) cancer was assessed for proteolytic fragments IgG. Serum samples 20 healthy donors were used as a control. We analyzed indicators hemostasis (prothrombin time, fibrinogen, plasminogen activity, a2-antiplasmin protein C activity) in blood plasma the level total IgG serum. The median IgG-LysK lower than cancer. ROC-analysis showed high sensitivity (91%) specificity (85%) group but 68% 85%, respectively, Analysis false negatives...
The cells of the multicellular organism interact with each other through system cell contacts. In particular, epithelial are characterized by formation dense intercellular contacts that allow effectively carry out transport. A large number proteins take part in tight contact, particular claudin family and zonulin. process malignant transformation, there is a loss interactions change expression responsible for their acquiring mesenchymal phenotype neoplastic cells. Objective comparative...
The data of a comparative enzyme-linked immunosorbent assay the content soluble form immunity checkpoint VISTA in blood serum 30 healthy donors (control group), 79 patients with primary malignant (osteosarcoma - 30, chondrosarcoma 31, chordoma 14) and 14 borderline (giant cell tumor) bone neoplasms are presented. In general group bones, median sVISTA is statistically significant lower than control (p = 0.040). tumors over 18 years age, there was decrease age levels. There were no differences...
B7-H3, also called CD276, is a type I transmembrane glycoprotein that encoded on human chromosome 15. It was discovered back in 2001. The original study described it as positive co-stimulant, can stimulate T-cell response and IFN-y production. However, recent researches have shown B7-H3 involved inhibition. A receptor has not been yet identified, this may explain the complex immunomodulatory activity of more than one binding partner with different functions. Expression protein found...
Background . Due to diversity of cancer, the functional role galectin-3 is rather controversial; however, for many types neoplasms, marker acts as a tumor growth promoter. Aim To perform comparative analysis levels in blood serum healthy individuals and patients with benign, borderline, malignant bone tumors divided into two age groups (under over 18 years age) based on main clinical morphological characteristics disease prognosis. Materials methods The study included 201 borderline (giant...
Introduction . Enzyme-linked immunosorbent assay of biochemical markers is one the most important methods for diagnosing tumors. One these an inducer expression matrix metalloproteases EMMPRIN/CD147. Changes in its are associated with progression some This study first work devoted to content soluble form transmembrane glycoprotein EMMPRIN (sEMMPRIN) blood serum patients various bone Aim To sEMMPRIN malignant tumors, relationship clinical and morphological characteristics neoplasms prognosis....