A5061566054- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Bone health and treatments
- Neuroblastoma Research and Treatments
- Radiopharmaceutical Chemistry and Applications
- Multiple Myeloma Research and Treatments
- Medical Imaging Techniques and Applications
- Medical Imaging and Pathology Studies
- Ovarian cancer diagnosis and treatment
- S100 Proteins and Annexins
- Iron Metabolism and Disorders
- Biomarkers in Disease Mechanisms
- Erythropoietin and Anemia Treatment
- Peptidase Inhibition and Analysis
- Sarcoma Diagnosis and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Chemotherapy-induced organ toxicity mitigation
- Bone Metabolism and Diseases
- Monoclonal and Polyclonal Antibodies Research
- Bone health and osteoporosis research
- Protein Degradation and Inhibitors
- Potato Plant Research
- Lanthanide and Transition Metal Complexes
- Reproductive Biology and Fertility
- Metabolism, Diabetes, and Cancer
Ministry of Health of the Russian Federation
2002-2024
National Medical Research Center of Cardiology
2023
Russian Cancer Research Center NN Blokhin
2001-2021
Academy of Medical Sciences
1997-2021
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation
2021
Moscow State University of Medicine and Dentistry
2016
Laboratoire de Biochimie
2016
Russian Academy of Sciences
2003-2014
Cancer Research Center
2000-2014
Institute of Theoretical and Experimental Biophysics
2004
Experimental evidence has been obtained to support the view that late necrosis in brain, after irradiation, is a consequence of damage vascular system. Rats were locally irradiated brain with single dose 25 Gy X-rays and their response was compared rats given same treatment administration radioprotector, Gammaphos. Time-dependent changes endothelial cell number determined for up 65 weeks irradiation. The complex pattern number, seen irradiation alone, not found animals receiving Gammaphos...
Radiation-induced loss of mouse brain endothelial cells has been examined in mice given an intravenous injection the DNA-binding radioprotector Hoechst 33342 (80 mg kg−1). At time irradiation, 10 min after injection, fluorescence was confined to cells. Endothelial cell density measured using a histochemical technique that had used previously monitor post-irradiation changes rat brain, which it shown sensitive subpopulation comprising about 15% lost within 24 h radiation exposure. The present...
Fragments of collagen type I containing the epitope AHDGGR (CTX) are generated during bone resorption. The aspartyl-glycine (DG) site within CTX is synthesised in L-aspartyl peptide (alphaL) form, but converts to age-modified forms L-isoaspartyl (betaL) and D-aspartyl (alphaD) over time. purpose present study was test ability various identify breast cancer patients with metastases investigate whether such had an altered excretion pattern.In this cross-sectional we compared healthy...
Bone metastasis is one of the most frequent and dangerous complications malignant tumors. The last years, achievements in study bone remodeling mechanisms promoted search sensitive specific criteria reflecting intensity osteolysis osteosynthesis metastatic lesions. informative clinically valid biochemical markers formation resorption are characterized this review. data on their possible implications diagnostics, monitoring prognosis skeletal lesions by various tumors presented. attention to...
A study of the clinical analysis blood and major metabolites ferrokinetics in 107 breast cancer patients before treatment was conducted. In 31 (28.9%) revealed anemic syndrome (AS). feature AS is pronounced microcytosis, erythrocyte hypochromia low hemoglobin content reticulocytes. Most often (n = 22; 71%) there iron deficiency (IDA), which characterized by a concentration (F), ferritin (FR), hepcidin 25 (GP25), interleukin-6 (IL-6) high - soluble transferrin receptors (rTFR), (TRF). 9 (29%)...
We present the comparative study of plasma chromogranin A (CgA) levels measured in 232 patients with different types neuroendocrine tumors (NETs) and 66 healthy individuals using enzyme immunoassay Chromogranin ELISA kit (Dako). CgA were significantly higher all NETs than subjects. secretion highly variable. The demonstrate high diagnostic sensitivity CgA, which was 80.6 % overall group specificity 98.5 %. confirmed prognostic significance this case basal (above 100 U/l) associated less...
Система комплексной поддержки и сопровождения научного журнала Elpub позволяет запустить двуязычный сайт со встроенной системой электронной редакции в соответствии с лучшими издательскими практиками, а так же предусматривает техническую методическую поддержку стороны специалистов НЭИКОН.
Bone metastasis is one of the most frequent and dangerous complications malignant tumors. The last years, achievements in study bone remodeling mechanisms promoted search sensitive specific criteria reflecting intensity osteolysis osteosynthesis metastatic lesions. informative clinically valid biochemical markers formation resorption are characterized this review. data on their possible implications diagnostics, monitoring prognosis skeletal lesions by various tumors presented. attention to...
A study of interleukin-6 (IL-6), hepcidin-25 (GP-25) was conducted in 22 patients with breast cancer before neoadjuvant chemotherapy and 27 healthy women the control group. Significant expression GP-25 protein revealed patients, compared to control. The rates were high both anemic sindrome (AS) without it (p <0.01). Latent iron deficiency, AS, IDA functional deficiency (FJ) more often detected stage III disease. significant difference parameters IL-6 noted, indicators higher No close...
Background. The most important problems in improvement of treatment outcomes patients with renal cell carcinoma (RCC) are search and validation molecular markers for its early diagnosis prognosis. Genes suppressing distant metastasizing but not affecting the primary tumor called metastasis suppressors. Study these genes their products only improves understanding mechanisms progression, has practical value diagnosis, prognosis, establishment new targets antitumor therapy. One such is KISS1...
Background: Neuroendocrine tumors (NETs) are a group of neoplasms, in which circulating biomarkers chromogranin A (CgA), serotonin, and N-terminal brain natriuretic pro-peptide (NT-proBNP), used as marker carcinoid heart disease, especially important the diagnosis monitoring. number pre-analytical factors, including patients' body mass index (BMI), have an impact on NETs biomarker concentrations. Aim: To perform comparative analysis serum concentrations CgA, serotonin NT-proBNP patients with...