Л.М. Михалева

ORCID: 0000-0003-2052-914X
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About
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Research Areas
  • Endometriosis Research and Treatment
  • Reproductive System and Pregnancy
  • Gynecological conditions and treatments
  • Gastric Cancer Management and Outcomes
  • Uterine Myomas and Treatments
  • Pregnancy and preeclampsia studies
  • Gastrointestinal Tumor Research and Treatment
  • Eosinophilic Esophagitis
  • COVID-19 Clinical Research Studies
  • Endometrial and Cervical Cancer Treatments
  • Amyloidosis: Diagnosis, Treatment, Outcomes
  • Ovarian cancer diagnosis and treatment
  • Maternal and fetal healthcare
  • Stress Responses and Cortisol
  • Metastasis and carcinoma case studies
  • Mitochondrial Function and Pathology
  • Gastrointestinal disorders and treatments
  • Pancreatitis Pathology and Treatment
  • COVID-19 and healthcare impacts
  • Healthcare Systems and Public Health
  • Esophageal Cancer Research and Treatment
  • Helicobacter pylori-related gastroenterology studies
  • Pelvic floor disorders treatments
  • Eosinophilic Disorders and Syndromes
  • Cancer Cells and Metastasis

Research Institute of Human Morphology
2015-2025

Russian Medical Academy of Continuous Professional Education
2022-2025

City Clinical Hospital No 31
2017-2025

Russian Scientific Center of Surgery
2022-2025

Pirogov Russian National Research Medical University
2002-2024

National Research Centre
2022-2023

Ministry of Health of the Russian Federation
2022

City Clinical Hospital
2016-2021

Research Centre for Medical Genetics
2020

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation
2020

The research aim is to study the morphological features of COVID-19 in lungs patients who died Moscow from March 20 June 6, 2020. Methods . Autopsy material 123 deceased (54 women, 69 men) with coronavirus infection (confirmed by PCR) was analyzed, median age 71 (30 – 94) years, and duration disease 14 (3 65) days. In all cases, patient's medical records autopsy reports were analyzed. Macro- microscopic changes evaluated observations. Results pathology corresponds various phases diffuse...

10.18093/0869-0189-2020-30-5-519-532 article EN cc-by-nc PULMONOLOGIYA 2020-10-26

A number of elderly patients commit suicide due to the interaction various factors, including, for example, feelings loneliness, financial distress, alcohol abuse, chronic pain, progressive diseases, and personality disorders. The data from EU countries with highest rates attempts among people over 55 years age warrant consideration new approaches address this social problem.PubMed other databases, including Polish National data, were used analyses.The average European suicide-attempt rate...

10.2174/1381612826999201126202008 article EN Current Pharmaceutical Design 2020-11-27

da Vinci robot-assisted axillary lymph node dissection (dVALND) can be a minimally invasive technique to minimize post-operative complications.To explore the clinical efficacy of dVALND in breast cancer (BC) patients for mitigating postoperative complications than conventional ALND.Total 60 female with BC were admitted our hospitals since September 2018, and these segregated into two groups 30 each. Modified radical mastectomy was performed both groups. In Group 1 (control group), ALND using...

10.1002/rcs.2307 article EN International Journal of Medical Robotics and Computer Assisted Surgery 2021-07-16

Transplantation of various types stem cells as a possible therapy for stroke has been tested years, and the results are promising. Recent investigations have shown that administration conditioned media obtained after cell cultivation can also be effective in central nervous system pathology (hypothesis their paracrine action). The aim this study was to evaluate therapeutic effects medium hiPSC-derived glial neuronal progenitor rat middle cerebral artery occlusion model ischemic stroke....

10.3390/ijms22094694 article EN International Journal of Molecular Sciences 2021-04-29

Macrophages are a central component of innate immunity that play an important role in the defense organism. highly plastic and activated by interaction with other cells environmental factors. In this work, we study effect lipopolysaccharide on macrophages derived from two most polar (CD14+ CD16+ monocytes) as well intermediate subset blood monocytes healthy donors assess what happens to prone polarization transcriptomic proteomic level. It has been shown that, according primary...

10.1016/j.biopha.2021.111614 article EN Biomedicine & Pharmacotherapy 2021-04-27

PTSD is associated with disturbed hepatic morphology and metabolism. Neuronal mitochondrial dysfunction considered a subcellular determinant of PTSD, but link between damage in has not been demonstrated. Thus, the effects experimental on livers high anxiety (HA) low (LA) rats were compared, determinants underlying difference their investigated. Rats exposed to predator stress for 10 days. Then, 14 days post-stress, evaluated an elevated plus maze assigned HA LA groups according index....

10.3390/ijms241613012 article EN International Journal of Molecular Sciences 2023-08-21

The increased number of cesarean sections worldwide has triggered the appearance new iatrogenic complications, such as unstable scars and atypical placental positions with villi invading scar. Unlike rapid physiological regeneration endometrium during menstrual cycle, scar after dipnoous incision uterine wall forms slowly, undergoing stage hypoechoic niche in lower segment characteristic symptoms cesarian defect. Myotomy results an interconception period that differs from stable one by...

10.31088/cem2025.14.1.68-76 article EN CLINICAL AND EXPERIMENTAL MORPHOLOGY 2025-01-01

Microbiota as a predictor of malignant neoplasms the gastrointestinal tract has been extensively studied in medicine, and an increasing number research is being devoted to determination bacterial flora tumors. However, there assumption that it presence viral agents play important role development particular organ digestive system due changes genome infected cells invasion inflammatory reaction infections. This literature review describes infectious carcinogenesis organs tract, presents...

10.31088/cem2025.14.1.5-12 article EN CLINICAL AND EXPERIMENTAL MORPHOLOGY 2025-01-01

Melanoma is a skin cancer caused by malignancy of melanocytes.Damage to the central nervous system in melanoma diagnosed 40–50% patients with metastatic form disease. This article presents clinical and morphological case penile lesions pia mater, cortex, subcortical nuclei both hemispheres small nodules 0.2 cm diameter absence metastases white matter, brainstem, cerebellum. mosaic distribution gives brain tissue patchy appearance and, best our knowledge, has not yet been described. The...

10.31088/cem2025.14.1.62-67 article EN CLINICAL AND EXPERIMENTAL MORPHOLOGY 2025-01-01
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