Aim . Current recommendations of the Russian Gastroenterological Association are developed to acquaint medical practitioners with modern diagnostics, treatment and trends in rational drug therapy for gastroesophageal reflux disease (GERD). General provisions Incidence rate GERD Federation varies from 11.3 23.6%. is diagnosed history laboratory examination evidence. Esophagogastroduodenoscopy (EGDS) allows detection esophagitis various severity cylindrical epithelial metaplasia esophagus. The...

The research aim is to study the morphological features of COVID-19 in lungs patients who died Moscow from March 20 June 6, 2020. Methods . Autopsy material 123 deceased (54 women, 69 men) with coronavirus infection (confirmed by PCR) was analyzed, median age 71 (30 – 94) years, and duration disease 14 (3 65) days. In all cases, patient's medical records autopsy reports were analyzed. Macro- microscopic changes evaluated observations. Results pathology corresponds various phases diffuse...

The objective: to predict lethal outcomes in patients with COVID-19 based on the result of chest computed tomography (chest CT) using a semi-quantitative visual scale pulmonary parenchyma lesion. Subjects and methods. Inclusion criteria: who underwent CT from March 2 May 1, 2020, inclusively, upon referral general practitioner due suspected community-acquired pneumonia caused by COVID-19. Chest was performed 48 medical organizations providing primary care adult population Moscow. Exclusion...

To determine the trends of primary antibiotic resistance Helicobacter pylori strains isolated from patients living in Moscow. As part a clinical and laboratory study, 123 gastric biopsy specimens H. pylori-infected were analyzed 2015 to 2024. infection was verified by rapid urease test 13C-urease breath test. The anaerobic culture technique used. After identifying pure culture, its susceptibility four antibacterial agents (amoxicillin - AMC, clarithromycin CLR, metronidazole MET,...

to comparatively analyze standardized mortality ratios (SMR) from stroke in the populations aged over 30 years Russian Federation and USA a 15-year period.The analysis included nontraumatic subarachnoid hemorrhage (NTSH) (a group of ICD-10 codes I60), intracerebral (NTIH) (I61), cerebral infarction (CI) (I63), stroke, not specified as or (SNSHI) (I64). The new European standard (European Standard Population.2013) was used for standardization. data Federal State Statistics Service Federation,...

Aim of publication. To present the latest data on adequate diagnostic methods, treatment approaches and features rational pharmacotherapy gastroesophageal reflux disease (GERD) based principles evidence­based medicine to general practitioners. Summary. The prevalence GERD occupies first place other gastroenterological diseases. heartburn that is a leading symptom at 20-40% population developed countries. in Russia ranges 18­46%. Diagnosis early stages primary appealability clinical...

Background: Pathological anatomy, patogenesis and the morphogenesis of manifestations complications COVID-19 remain insufficiently studied. The fullest information on structural bases organs tissues alterations by new coronavirus disease can be obtained as a result autopsies.
 Aims: aim study was to morphological changes lungs other autopsies deceased persons. Results 2000 people who died severe form in Moscow, consisting 1212 men 788 women, from March 20 May 22, 2020 (a ratio 1.54:1)...

<h3></h3> Предлагаемая согласованная позиция экспертов призвана обсудить известные подходы к диагностике, лечению и вторичной профилактике тромботических осложнений эндотелиальной дисфункции при COVID-19 для их применения в условиях поликлинического приема. Эксперты подтвердили место низкомолекулярных гепаринов у госпитализированных пациентов. Повреждение эндотелия является важным фактором развития гиперкоагуляции также пациентов с COVID-19, находящихся на амбулаторном лечении. По мнению...

to analyze the generally accepted histological criteria for diagnosing activity of inflammatory bowel disease (IBD) in patients with therapy-induced endoscopic remission.Colon biopsy specimens from 57 aged 19 52 years (mean age 31±2.5 years), including 41 ulcerative colitis (UC) and 16 Crohn's (CD) affecting colon, were examined. All had no clinical signs activity; examination diagnosed remission (none or minimal changes). The taken all colon segments during colonoscopy processed by...

World literature is paying increasing attention to the long-term course of COVID-19 and symptoms that appear after acute coronavirus infection. The symptoms, functional state lungs, X-ray changes are assessed. Nevertheless, post-COVID lung histology has not been described yet. aim this article study pathological in lungs COVID-19. Methods. We analyzed autopsy material from 19 deceased who had average age was 68.82 ± 14.6 years. All patients were found have IgG SARS-CoV-2. median time death...

Introduction. The pathogenesis of the novel coronavirus infection COVID-19 is being actively studied. Nevertheless, our up-to-date knowledge lymphoid tissue response in secondary immune organs dur-ing severe remains extremely limited. aim study was to evaluate patterns immu-nomorphological alterations lymph nodes patients with and assess lymphocytes functional activity them. Materials methods. Lymph node (autopsy material) from 17 deceased examined by histological immunohistochemical methods...

Aim. Retrospective analysis of the underlying causes for death patients who did and not seek outpatient medical care (OPMC) ischemic heart disease (IHD), discussion a possibility using administrative anonymized but individualized databases analysis. Material methods. The electronic database Central Administration Civil Registry Office Moscow Region (Unified State Register Region), including certificates (MDC) 2021, was used to select all cases fatal outcomes with codes International...

There is a huge amount of commensal bacteria and food antigens in the large intestine. At same time, pathogenic microorganisms can enter A macroorganism needs to maintain tolerance first develop an effective immune response latter. The epithelial barrier colon plays leading role realization this task. Dysfunction leads development inflammatory normal intestinal antigens, which, according some authors, initial mechanism ulcerative colitis development. This review dedicated modern concepts...

The purpose of the review: to summarize main data literature and our own accumulated practical experience everyday diagnosis inflammatory bowel diseases (IBD) better represent morphological features histological conclusions. Key points. microscopic picture IBD is often represented by a combination basic characteristics that can be detected in other only rare cases considered pathognomonic. No single feature used isolation diagnose ulcerative colitis or Crohn’s disease. Diagnostic accuracy...

The aim of the study was to compare effectiveness laser singlet phototherapy and traditional photodynamic therapy treatment periodontal diseases in an animal model. experimental model involved 70 male rats Wistar which periodontitis modeled treated: group I (30 animals) a nanosecond device for medical use with wavelength 1270 nm used 7 sessions 400 ns pulse mode, average radiation power 2 W, density 200 J/cm2, II received administration photosensitizer, followed by irradiation 660 Wt power,...

For organization of health care, it is important to know the requirement for its individual types, including number hospitalizations and use expensive technologies. Heart failure (HF) syndrome in patients with cardiovascular diseases often determines their severity prognosis. However, being a complication underlying disease, HF not included into statistical reports medical bills compulsory insurance system. This article focuses on issues evaluating prevalence mortality different countries...

In a review article based on my own clinical experience of managing patients with acute myocardial injury and fulminant myocarditis, taking into account expert recommendations the treatment damage associated novel coronavirus infection National geriatric medical research center, division cardiovascular diseases, Chinese geriatrics society, Department cardiology, Beijing Medical Association European clinics discusses pathogenesis, diagnosis FM patients, infected SARS-CoV-2 in context COVID-19...

The differences in mortality rates between Moscow and St. Petersburg require study. Aim . Ranking comparison of cardiovascular 2015 2018. Material methods Data on the population was assessed according to Brief nomenclature causes death Federal State Statistic Service. Eleven out 35 lines related disease (CVD) are represented by 4-digit ICD codes, rest groups with 3- and/or codes. Standardized (SMRs) were calculated based European standard. Comparison SMR 2018 carried using nonparametric...

Acute respiratory distress syndrome (ARDS) with COVID-19 has a worse prognosis than ARDS other diseases. Mortality from is 26.0 - 61.5%, and due to causes 35.3-37.2%.To find of the correlation between polymorphonuclear leukocytes (PMNs), lymphocytes, macrophages in cellular composition inflammatory infiltrate at different stages phases diffuse alveolar damage (DAD) COVID-19, analyzing autopsy material.The lung tissue 25 patients who died without secondary bacterial or mycotic infection,...

Aim. Determine the primary antibiotic resistance of Helicobacter pylori (H. pylori) strains isolated from patients living in European part Russian Federation. Materials and methods. As a clinical laboratory study, 2015 to 2018, 27 gastrobiopsy samples obtained H. pylori-infected were analyzed. infection was verified using rapid urease test or 13C-urea breath test. The values minimum inhibitory concentration (MIC) antibiotics determined by diffusion method E-test strips (BioMerieux, France)...

to investigate the specific features of somatostatin receptor expression in ileal mucosa patients with inflammatory bowel disease (IBD).Ileal biopsy specimens from 42 aged 22 55 years, including 16 Crohn's (CD), 14 indeterminate colitis IBD unclassified (IBDU), and 12 unchanged (a comparison group). Immunohistochemical examination was performed using anti-somatostatin type 2 (SSTR-2) antibodies (Epitomics, USA). SSTR2-positively stained cells were counted per 100 epitheliocytes.There three...

To investigate the expression of moesin, p21-activated kinase 4 (PAK 4), matrix metalloproteinases (MMP 2, MMP 9), and CD34 in eutopic ectopic endometrium different forms adenomyosis.Fifty uteri removed for diffuse adenomyosis adenomyomas were examined reproductive-aged (n=25) premenopausal women. A comparison group included 20 intramural subserosal fibroids The investigators performed histological immunohistochemical (using antibodies to PAK 4, 9, CD34) examinations endometrium.Different...

Purpose of research: To study methodological, organizational and normative problems comparison final clinical pathological-anatomical diagnoses in the Russian Federation on basis a review domestic foreign publications.Abstract: Clinical anatomical comparisons remain most important function quality control medical diagnostic work. Cases divergence should be subject professional discussion community with adoption appropriate administrative measures to address deficiencies provision care....