A5065212555- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Kruppel-like factors research
- Bone and Joint Diseases
- Cardiac tumors and thrombi
- Lymphoma Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Lysosomal Storage Disorders Research
- Cancer Immunotherapy and Biomarkers
- Cytomegalovirus and herpesvirus research
- Parvovirus B19 Infection Studies
- Herpesvirus Infections and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
National Medical Research Center for Hematology
2020
Public Health Dayton & Montgomery County
2020
Ministry of Health of the Russian Federation
2019
BACKGROUND: Osteonecrosis of the femoral head in Gaucher disease typeI is an irreversible bone manifestation disease. The cause and mechanisms osteonecrosis are still unknown, their clinical radiological characteristics must be taken into account when choosing treatment strategy. AIM: To analyze radial morphological changes proximal femur after MATERIALS AND METHODS: study included 251adult patients with from Russian National Registry; histological examination 22removed fragments obtained...
Introduction. The pathogenesis of the novel coronavirus infection COVID-19 is being actively studied. Nevertheless, our up-to-date knowledge lymphoid tissue response in secondary immune organs dur-ing severe remains extremely limited. aim study was to evaluate patterns immu-nomorphological alterations lymph nodes patients with and assess lymphocytes functional activity them. Materials methods. Lymph node (autopsy material) from 17 deceased examined by histological immunohistochemical methods...
Mediastinal gray-zone lymphoma (MGZL, with features intermediate between classical Hodgkin and diffuse large B-cell lymphoma) was declared as a separate entity in WHO classification of Tumors Haematopoetic Lymphoid Tissues 2008 2017 years. Despite similar pathomorphological characteristics primary mediastinal lymphoma, clinical optimal therapeutic approach to MGZL are not clearly defined. Usually manifests lymphadenopathy, although extranodal lesions often occur (grey-zone GZL). Patients...
Aim. To study the structure of Ph-negative myeloproliferative diseases (Ph- MPD) and to identify morphological markers for diagnosing masked polycythemia vera (PV). Materials & Methods. Bone marrow core biopsy samples from database pathology department National Research Center Hematology within period January 2014 June 2017 provided basis analyzing diagnosed Ph- MPD cases. The trial included bone patients treated fol-lowed-up not only at but also other medical centers in Russian...
Background. As morphological pattern of bone marrow (BM) biopsy samples at advanced stages clonal evolution in essential thrombocythemia (ET) appears similar to that the development post-thrombocythemic myelofibrosis and primary (PMF), expression fibro-genesis factors by atypical megakaryocytes (MKC) acquires increased interest. Aim. To study transforming growth factor TGFβF1 MKC; relate number TGFβF1-positive MKCs with degree BM stroma fibrosis trabecular changes patients ET different PMF...
Indications of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with primary myelofibrosis are intermediate-2 and high-risk group DIPSS (Dynamic International Prognostic Scoring System), beginning the disease childhood. The other adverse factors affect engraftment survival after allo-HSCT, example partialy matched donor. But result allo-HSCT from related donors haploidentical comparable. method for is T-cell-depletion. This clinical case T-cell-depleted patient...
Aim. To estimate graft function after kidney transplantation during active herpesviruses or superinfection Materials and methods. The study included 32 patients (men 21, women 11) with end-stage chronic disease. median age was 43 years. Cytomegalovirus (CMV), EpsteinBarr virus (EBV) human herpes 6 (HHV-6) DNAs were screened by RT-PCR in the donor's transplant biopsy, recipients peripheral blood urine (KT) on 0, 1, 2, 4, 6, 12 months. Antiviral antibodies (IgM IgG) also Enzyme-linked...