A5087877773- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Chronic Lymphocytic Leukemia Research
- Polyomavirus and related diseases
- CAR-T cell therapy research
- COVID-19 and healthcare impacts
- Xenotransplantation and immune response
- Renal Transplantation Outcomes and Treatments
- Long-Term Effects of COVID-19
- Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Mesenchymal stem cell research
- Clinical Nutrition and Gastroenterology
- COVID-19 Clinical Research Studies
Introduction. The COVID-19 pandemic has changed the conditions for providing medical care to hematological patients, including those who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT). Objective: analyze course of new coronavirus infection in patients have undergone allo-HSCT. Materials and methods. retrospective study included 87 developed after allo-HSCT period from March 2020 January 2022. In most cases, transplants were performed with acute leukemia (77 %) using...
Introduction. The current overall effectiveness of acute myeloid leukemia (AML) treatment is largely ensured by the integration transplantation technologies, but not all patients who are indicated to undergo allogeneic hematopoietic stem cells (allo-HSCT) can reach this stage. Aim: analyze time and volume implementation allo-HSCT in with AML first complete remission (1CR). Materials methods. Between January 2020 December 2023, 477 from 43 different regions Russian Federation were referred...
Introduction. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a standard treatment for many patients with hematological malignancies. Over the past 20 years, an increase in activity has been noted throughout world. About 50 % of all allo-HSCT are transplanted from unrelated donors. Aim: to present dynamics and stages development donation using example one transplant center. Materials methods. This study analyzed Allo-HSCT performed 2009 March 2019 at National Research...
Introduction . The introduction of chimeric antigen receptor (CAR) T-cell therapy is a promising treatment patients with relapsed or refractory (R/R) B-cell lymphoproliferative diseases (LPDs). Aim — to present the results CAR-T-cell 6 adult LPDs. Materials and methods This pilot study conducted in R/R persistent minimal residual disease LPDs treated CAR-T-cells. was approved by local ethical committee National Research Center for Hematology. Patients did not have alternative options...
Introduction . One of the main causes treatment failure after allogeneic hematopoietic stem cells transplantation (alloHSCT) for acute leukemia (AL) is disease relapse. In recent years, multiparameter fl ow cytometry (MPC) has been widely used to detect minimal residual (MRD) because its capacity identify patients with a high risk relapse due availability and ability obtain results in timely manner. Aim — evaluate prognostic value MRD status before allo-HSCT effect donor type conditioning...
Background. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a standard treatment for many patients with hematological malignancies. Complications of allo-HSCT are frequently associated either relapse the underlying disease or graft failure. Second can be offered to selected and seen as only curative option. In this paper, we report experience managing 24 such patients, all whom underwent second allo-HSCT. Patients methods. The research involved (12 males/12 females)...
Introduction . Mutations in the TP53 gene patients with mantle cell lymphoma (MCL TP53+) are associated a low response to intensive chemotherapy (CT) and adverse outcomes. Allogeneic haematopoietic stem cells transplantation (allo-HSCT) is curative approach MCL-TP53+ patients. Aim Efficacy safety assessment of allo-HSCT Main findings During 2016–2020, MCL TP53+ was performed three Two them were grafted from HLA-identical unrelated donors, one — haploidentical donor. Pre-transplant conditioning...
Introduction. Haematopoietic stem cell transplantation is the treatment of choice in many patients with malignant diseases blood system. In such patients, acute graft-versus-host disease (GvHD) associated intestinal damage constitutes one most serious complications. However, volume stool per day, which currently used as main diagnostic criterion for conditions, does not always permit a timely diagnosis. Aim . To study possibility using intestine ultrasound examination diagnosis GvHD....
Introduction. Chronic graft versus host disease (GVHD) is a frequently occurring complication after transplantation of allogeneic hematopoietic cells associated with decrease in the quality life and long-term administration immunosuppressive drugs. Extracorporeal photopheresis (ECP) second line therapy treatment failure glucocorticoids. Aim — to evaluate effects ECP patients glucocorticosteroids (GCS)-refractory, GCS-dependent or GCS -intolerant chronic GVHD. Materials methods. 24...
Indications of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with primary myelofibrosis are intermediate-2 and high-risk group DIPSS (Dynamic International Prognostic Scoring System), beginning the disease childhood. The other adverse factors affect engraftment survival after allo-HSCT, example partialy matched donor. But result allo-HSCT from related donors haploidentical comparable. method for is T-cell-depletion. This clinical case T-cell-depleted patient...
Introduction. The mechanism of action extracorporeal photopheresis (ECP) is associated with the induction apoptosis lymphocytes, which cause activation antigen-presenting cells (APC). As a result use ECF, number T-regulatory lymphocytes increases, induces an immunosuppressive effect. actual problem lies in cryopreserved and photo-irradiated mononuclear cells. Aim — to analyze functional features after ECP. Materials methods. study analyzed indicators early late stages concentrate different...