A5088700732- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Renal Transplantation Outcomes and Treatments
- Mesenchymal stem cell research
- Blood transfusion and management
- Cancer Immunotherapy and Biomarkers
- Bone and Joint Diseases
- Single-cell and spatial transcriptomics
- Polyomavirus and related diseases
- RNA Interference and Gene Delivery
- Nutrition and Health in Aging
- Cytomegalovirus and herpesvirus research
- Hemostasis and retained surgical items
- Cancer Genomics and Diagnostics
- Childhood Cancer Survivors' Quality of Life
- Hemophilia Treatment and Research
- Immunodeficiency and Autoimmune Disorders
- Clinical Nutrition and Gastroenterology
- Platelet Disorders and Treatments
- Synthesis of Tetrazole Derivatives
- Immunotherapy and Immune Responses
National Medical Research Center for Hematology
2019-2022
Perm State Medical Academy
2018
Introduction. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a standard treatment for many patients with hematological malignancies. Over the past 20 years, an increase in activity has been noted throughout world. About 50 % of all allo-HSCT are transplanted from unrelated donors. Aim: to present dynamics and stages development donation using example one transplant center. Materials methods. This study analyzed Allo-HSCT performed 2009 March 2019 at National Research...
The article presents a brief review of the literature on current understanding etiology, pathogenesis, clinic, diagnosis and treatment acquired form hemophilia, as well clinical case this pathology with successful treatment.
Background: Primary and secondary graft failure (GF) following allogeneic hematopoietic stem cell transplantation (allo‐HSCT) leads to prolonged neutropenia, infection complications as a consequence lowered overall survival. Bone marrow source, HLA‐mismatched donor is main factors which can influence GF in acute leukemia patients (pts) during first six months after allo‐HSCT. Nevertheless not all episodes be explained by this factors. Here we report data about of spleen size (length width)...
Background: Cytomegalovirus (CMV) is the opportunistic infection that persists in healthy individuals asymptomatically and reactivates immunodeficient host, e.g. after allo‐HSCT. The main cause of viral reactivation lack CMV‐specific T cells. adoptive cellular therapy with cells seems very attractive clinical option to accelerate virus‐specific T‐cell reconstitution Here we report preliminary data about allo‐HSCT patients. Aims: To identify a group patients who are high‐risk CMV could be...
Background: Programmed cell death protein 1 (PD‐1) is a surface receptor expressed normally on distinct immune cells. It's well known PD‐1 pathway blockade negative regulatory mechanism that has detrimental effects anti‐tumor immunity. Currently some studies have revealed different cells overexpressed as predictable marker of leukemia relapse. On the other hand its assay after allo‐HSCT could be controversial due to alternative GVHD prophylaxis regimens might affect expression, such...
Introduction. Chronic graft versus host disease (GVHD) is a frequently occurring complication after transplantation of allogeneic hematopoietic cells associated with decrease in the quality life and long-term administration immunosuppressive drugs. Extracorporeal photopheresis (ECP) second line therapy treatment failure glucocorticoids. Aim — to evaluate effects ECP patients glucocorticosteroids (GCS)-refractory, GCS-dependent or GCS -intolerant chronic GVHD. Materials methods. 24...