A5052728033- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Metastasis and carcinoma case studies
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Sarcoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Renal cell carcinoma treatment
- Circular RNAs in diseases
- Esophageal Cancer Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Multiple and Secondary Primary Cancers
- Protease and Inhibitor Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Growth Hormone and Insulin-like Growth Factors
Rostov Research Institute of Oncology
2015-2024
Ministry of Health of the Russian Federation
2015-2024
Rostov State Medical University
2020-2024
National Medical Research Center of Cardiology
2023
Russian Academy of Sciences
2018-2022
Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
2022
Institute of Molecular Pathology and Pathomorphology
2022
Vladivostok State Medical University
2022
Federal Scientific Center of the East Asia Terrestrial Biodiversity FEB RAS
2022
Far Eastern Federal University
2022
The role of machine learning (a part artificial intelligence—AI) in the diagnosis and treatment various types oncology is steadily increasing. It expected that use AI will speed up both diagnostic planning processes. This review describes recent applications oncology, including medical image analysis, planning, patient survival prognosis, synthesis drugs at point care. fast reliable analysis images great importance case fast-flowing forms cancer. introduction ML for constantly growing...
Purpose of the study. To develop a diagnostic calculator for assessing expression profile microRNAs (miRNAs) that are significant oncogenesis thyroid cancer, to introduce it into clinical practice and evaluate effectiveness proposed method early diagnosis malignant neoplasms gland in uncertain situations after fine-needle aspiration biopsy (FNAB). Material methods. The previously developed «Method Diagnosing Malignant Neoplasms Thyroid Gland» (patent RU2820815 C1) was tested on 284 patients...
Введение. Меланома представляет все больший интерес для исследований, особенно по мере выяснения конкретных биологических путей ее развития и прогрессирования. Важную роль в процессах меланомы играет митохондриальный метаболизм, перестройки которого влияют на выживаемость злокачественных клеток. Цель. Изучение способности митохондрий, изолированных из меланомы, образовывать опухолевые структуры организме животных. Материалы методы. В эксперименте использовали 17 самцов мышей линии С57ВL/6...
Purpose of the study . To examine influence specific factors on apoptosis process in mitochondria cells located various regions colon, with a focus patients both sexes. Patients and methods The included results obtained from 132 T2–3N0M0 colon cancer, comprising 52 women 80 men. Mitochondria were isolated human intestinal tumor tissue using differential centrifugation. concentration cytochrome C (ng/mg protein), AIF (pg/mg Bcl-2 calcium (mM/mg protein) determined. Results In men, level...
Abstract Non-small cell lung cancer (NSCLC) has limited treatment options. Expression of the RNA-binding protein (RBP) Musashi-2 (MSI2) is elevated in a subset non-small tumors upon progression, and drives NSCLC metastasis. We evaluated mechanism MSI2 action to gain therapeutically useful insights. Reverse phase array (RPPA) analysis MSI2-depleted versus control Kras LA1/+ ; Trp53 R172HΔG/+ lines identified EGFR as MSI2-regulated protein. expression activity an line panel was studied using...
Epigenetic processes play a critical role in melanoma development. However, little is known about proteins responsible for epigenetic transformations cells. The the peritumoral skin within excision margin are almost unstudied. We studied changes expression of 112 involved regulation gene human cutaneous and its zone using "The Proteomic Antibody Microarrays" (GRAA2, Sigma-Aldrich). Dimethylated histone H3 at lysines 4 9 as well transcription (histone deacetylases HDAC-1 HDAC-11, DNA...
6035 Background: Photodynamic therapy (PDT) is an effective treatment for various cancers ensuring maximum preservation of the viability healthy tissues surrounding tumor. The purpose study was to reveal effectiveness PDT in preinvasive cervical cancer. Methods: included 45 patients aged 22-53 years with were divided into two groups depending on type transformation area and tumor site: group 1–on exocervix (type I-II), n=24; 2–on endocervix III), n=21. Infection high-risk genotypes HPV (16,...
Aim: to evaluate prognostic factors in colorectal cancer. Material and methods: published data (publications PubMed, Scopus, eLIBRARY databases) own results of treatment 47 patients with T2-4N0-2M0 colon cancer 2017–2018. The following were studied: metastasis regional lymph nodes, tumor site, CEA level, KRAS BRAF mutation status, microsatellite instability, MUSASHI2, p53, VEGF. Results: a correlation between progression the status nodes demonstrated significant differences (p = 0.038): N0,...
Today, colorectal cancer (CRC) is the third most common and therefore an urgent problem of oncology. Despite all modern diagnostic capabilities, rates advanced cases are growing steadily. CRC was proven to be a result phased dysplastic change in colon mucosa, molecular genetic changes that determine biology tumor, its properties, morphology, disease prognosis response therapy. The following mechanisms tumor progression distinguished: chromosomal instability, microsatellite "methylator"...
The paper presents a brief review on how some concepts the organism general adaptational reactions developed, including their role in increasing unspecific resistance organism.Demonstrated is periodicity of patterns anti-stressor type (training, calm and elevated activation) stress wide range stimulation values.The reactivity levels have created theoretical basis for practical applications activation therapy aimed at health improvement, prevention treatment various diseases,...
УДК 616-006.3.04-036.8ВЛИЯНИЕ ВОЗРАСТНЫХ, ГЕНДЕРНЫХ И ГИСТОЛОГИЧЕСКИХ ХАРАКТЕРИСТИК НА ОТДАЛЕННУЮ ВЫЖИВАЕМОСТЬ БОЛЬНЫХ САРКОМАМИ МЯГКИХ ТКАНЕЙ 1 Кит О.И., Аушева Т.В., Максимов А.Ю., 2 Демидова А.А., Алиханова С.С., Шульга Галина А.В., Гурова С.В., Ващенко Л.Н. ФГБУ «Научный медицинский исследовательский центр онкологии» Министерства здравоохранения Российской Федерации, Ростов-на-Дону; ФГБОУ ВО «Ростовский государственный университет» Ростов-на-Дону
Purpose of the study. Assessment clinical safety and effectiveness radium‑223 in patients with bone metastases from castration-resistant prostate cancer. Patients methods. The study involved materials on 15 cancer aged 58–81 years, mean age 67.2 ± 6.5 who were examined received full treatment 6 intravenous injections chloride [223Ra] at National Medical Research Centre for Oncology. Most (73.3 %) showed ECOG 1 performance status. Pain syndrome before was registered 12 (80 patients. Results....
Musashi-2 (MSI2) is a member of RNA-binding protein family that regulates mRNA translation numerous intracellular targets and influences maintenance stem cell identity. This study assessed MSI2 as potential clinical biomarker in non-small lung cancer (NSCLC).The current included 40 patients with NSCLC, whom one presented stage 1, 14 II, 15 III, 10 had IV. All received standard care treatments. patient samples were obtained before treatment started. We used immunohistochemical (IHC) approach...
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Alkylresorcinols (ARs) are polyphenolic compounds with a wide spectrum of biological activities and potentially involved in the regulation host metabolism. The present study aims to establish whether ARs can be produced by human gut microbiota evaluate alterations content stool samples as well metabolic activity C57BL, db/db, LDLR (-/-) mice according diet specifications olivetol (5-n-pentylresorcinol) supplementation estimate regulatory potential ARs. Gas chromatography mass spectrometric...