A5062932354- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Esophageal Cancer Research and Treatment
- Peptidase Inhibition and Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Surgical Treatments
- Immunotherapy and Immune Responses
- Protease and Inhibitor Mechanisms
- Growth Hormone and Insulin-like Growth Factors
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- S100 Proteins and Annexins
- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- Cancer Mechanisms and Therapy
- Sarcoma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- Medical Imaging and Pathology Studies
Rostov Research Institute of Oncology
2016-2022
Fox Chase Cancer Center
2020-2021
Abstract Non-small cell lung cancer (NSCLC) has limited treatment options. Expression of the RNA-binding protein (RBP) Musashi-2 (MSI2) is elevated in a subset non-small tumors upon progression, and drives NSCLC metastasis. We evaluated mechanism MSI2 action to gain therapeutically useful insights. Reverse phase array (RPPA) analysis MSI2-depleted versus control Kras LA1/+ ; Trp53 R172HΔG/+ lines identified EGFR as MSI2-regulated protein. expression activity an line panel was studied using...
Musashi-2 (MSI2) is a member of RNA-binding protein family that regulates mRNA translation numerous intracellular targets and influences maintenance stem cell identity. This study assessed MSI2 as potential clinical biomarker in non-small lung cancer (NSCLC).The current included 40 patients with NSCLC, whom one presented stage 1, 14 II, 15 III, 10 had IV. All received standard care treatments. patient samples were obtained before treatment started. We used immunohistochemical (IHC) approach...
The RNA-binding protein Musashi-2 (MSI2) controls the translation of proteins that support stem cell identity and lineage determination is associated with progression in some cancers. We assessed MSI2 as potential clinical biomarker colorectal cancer (CRC) tubulovillous adenoma (TA) colon mucosa.
e21583 Background: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death in world, and metastasis most common patients. Musashi-2 (MSI2) a member RNA-binding protein family regulates mRNA translation numerous intracellular targets, influences multiple biological processes, including maintenance stem identity. Previously we reported that MSI2 upregulated metastasis-competent NSCLC murine human lines, drives metastasis, progressively elevated patient samples. This...
e24117 Background: Cancer-testis antigens (CTA) can be used as immunotherapy targets of cervical cancer. However, is often in combination with anthracycline antibiotics chemotherapy, particular doxorubicin(DXR), whose effects on the expression CTA genes have not been studied. Therefore, effect different concentrations DXR and exposure time cancer-testis (CT) HeLa cells was Methods: Cultivation CCL-2 (cervical cancer) performed CB 150 incubatorin RPMI-1640 medium various DXR: 0 (control), 2 4...
e23011 Background: Liver and lung metastases are frequent in cancer patients practically untreatable at the time of diagnosis. Oncological studies now focused on detection markers for early metastasis prediction. A lot data support an important role growth factors tumor development progression; however, these contradictory quite often. We performed a comparative study dynamics (IGF-I, IGF-II TGF-β1 ) liver lungs 1 2 weeks after to organs. Methods: The included 60 male Wistаr rats. Growth...
e15518 Background: The purpose of the study was to evaluate parameters local immunity in patients with esophageal cancer varying degrees differentiation. Methods: Tissues tumor and peritumoral zone obtained during surgery from 25 (6 women 19 men aged 40-77 years) mainly affecting upper thoracic (1 patient), mid (12) lower esophagus (11) were studied. Histological examination showed squamous cell carcinoma: 7 without keratinization 18 it. 8 had poorly differentiated tumor, 12 – moderately...
e15681 Background: Anastomotic leakage with arrosive bleeding (AB) develops in 4-29%% of the cases after surgery for pancreatic cancer. AB is mediated by destruction vascular wall resulting from local activation proteolysis. The purpose study was to determine general proteolysis blood plasma (BP) patients cancer (T3 N0 M0 ) before and surgery. Methods: Pancreatodigestive anastomosis performed 26 patients, pancreatoenteroanastomosis – 49, bypass gastroenteroanastomosis...
e15093 Background: An important role in tumor angiogenesis induction is played by hydrolytic systems, particular plasmin one which provides degradation of the extracellular matrix, activates growth factors and metalloproteinases. Our purpose was to analyze tissue fibrinolytic system α2-macroglobulin (α 2 M) primary adenocarcinoma (PA) polyps (P) rectum (R). Methods: Tissues tumors (РА, G2, T 2-3 N 0 M 0, 42-73 years) their perifocal zone (PZ) R (n = 24) Р 27) were studied ELISA; result...
e15128 Background: Liver metastasis from colorectal cancer dramatically reduces the treatment effectiveness and affects survival. Early detection of allows increasing median survival improving quality life patients. The purpose study was to reveal factors significant for prognosis liver cancer. Methods: Levels VEGF-A, VEGF-R EGF were studied by ELISA in tumors resection line tissues 113 patients with (rectal n = 43, colon 70). Results: VEGF-A levels all increased compared line. 46.5% rectal...
e23007 Background: Over the past 20 years, number of deaths from colorectal cancer (CRC) increased by 46% worldwide: every year more than 1 million people are diagnosed with this pathology. Proteomic studies using protein microarrays a very attractive strategy for screening new highly specific biomarkers which can improve prognosis prediction CRC. We performed proteomic study to find informative metastatic and non-metastatic be further used in routine histochemical studies. Methods: The...
e15111 Background: Plasminogen activators play a key role in the cascade fibrinolytic system as they catalyze plasmin formation from plasminogen (PG). together with are directly or indirectly involved tumor growth. The purpose of study was to compare activation primary adenocarcinomas (РА) rectum (R) and without liver metastases (LM). Methods: Tissues tumors (РА, st. III, G2, 38-74 years) their perifocal zone (PZ) LM (T 2-3 N х M 1 , n = 24) them 0 32) were studied by ELISA. Results:...
e23094 Background: Today, the problem of early diagnostics lung cancer remains unsolved as every fourth patient diagnosed with disease already has distant metastases. Studying gene copy number variation (CNV) in extracellular DNA blood plasma can become a basis for new effective and low invasive method predictive prognosis. The purpose study was to examine MDM2 p53 genes patients metastatic non-metastatic healthy donors. Methods: samples 30 adenocarcinoma (collected before surgery) donors...
608 Background: Colorectal cancer is the second most common in women and third men. Major signaling pathways are known to be deregulated cancer, however, there only a few studies addressing activation status of more than one or two colorectal comparison with normal tissue. The present study aims compare expression pattern proteins associated cell paired tumor non-tumor samples patients colon as well define cluster differentiate non-metastatic (Dukes’ grade B) metastatic C&D) cancer....
e15623 Background: Growth factors and neoangiogenesis maintain the endothelial barrier homeostasis, form new vasculature for a tumor interact with sex hormones. Rectal sigmoid tumors are more frequent in men than women. The purpose of study was to analyze levels some growth primary adenocarcinomas (PAs) rectum (R) colon (SC) (M) women (W). Methods: Levels VEGF-A, IFR-1 IFR-2 TGF-β1 were studied cytosols tissue obtained from 78 patients (РА, st. III, G2, 49 29 aged 38-73 years, T1-3N0M0) by...
e15552 Background: Plasminogen activators play a key role in the cascade fibrinolytic system as they catalyze plasmin (P) formation from plasminogen (PG). together with are directly or indirectly involved tumor growth. The purpose of study was to compare activation primary adenocarcinomas (РА) rectum (R) and without liver metastases (LM). Methods: Tissues tumors (РА, st. III, G2, 38-74 years), their perifocal zone (PZ) resection line tissues LM (T2-3NхM1, n = 34) them (T2-3N0M0, 42) were...
Экспрессия некоторых молекулярно-биологических маркеров при раке пищевода в зависимости от стадий заболевания и степени дифференцировки
Most of melanomas the gallbladder are metastatic lesions cutaneous melanoma. Primary described as single, polypoid, intraluminal masses emanating from mucous membrane. The most important characteristic is absence melanoma damage to skin. If it not possible localize primary a multidisciplinary approach diagnostic search comes fore. Predicting for difficult task due small number cases and long-term follow-up this category patients.
УДК 616-006.66ЭКСПРЕССИЯ РНК-СВЯЗЫВАЮЩЕГО БЕЛКА MUSASHI-2 КАК НЕГАТИВНЫЙ ПРОГНОСТИЧЕСКИЙ МАРКЕР ПРИ МЕТАСТАТИЧЕСКОМ КОЛОРЕКТАЛЬНОМ РАКЕ Харин Л.В., Карнаухов Н
e16009 Background: The RNA-binding protein Musashi-2 (MSI2) controls the translation of proteins that support stem cell identity and lineage determination. Elevated expression MSI2 plays an important role during progression, dissemination, drug resistance in numerous solid hematological malignancies. This study assessed as potential clinical biomarker colorectal cancer (CRC) pre-malignant disorders colon mucosa. Methods: included 125 patients, whom 20 had tubulovillous adenomas (TAs) colon,...