A5002199661- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- COVID-19 and healthcare impacts
- Lung Cancer Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- Multiple and Secondary Primary Cancers
- Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Chemical Reactions and Isotopes
- Cancer Risks and Factors
- Effects of Radiation Exposure
- Colorectal and Anal Carcinomas
- Pleural and Pulmonary Diseases
- Hydrogen's biological and therapeutic effects
- Growth Hormone and Insulin-like Growth Factors
- Long-Term Effects of COVID-19
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- Inflammatory Biomarkers in Disease Prognosis
National Medical Research Center of Cardiology
2023
Rostov Research Institute of Oncology
2015-2022
Ministry of Health of the Russian Federation
2016-2021
It remains unclear whether extended lymphadenectomy provides oncological advantages in colorectal cancer. This multicentre RCT aimed to address this issue.Patients with resectable primary colonic cancer were enrolled four hospitals registered the COLD trial, and randomized D2 or D3 dissection a 1 : ratio. Data analysed assess safety of dissection.The study included first 100 patients ongoing trial. Ninety-nine intention-to-treat (ITT) analysis (43 D2, 56 D3). Ninety-two received allocated...
Background: Circulating tumor cells (CTCs) play an important role in hematogenous metastasis of malignant tumors. Small cell lung cancer (SCLC) is the most aggressive form with highest number detected CTCs. Objective: To evaluate presence and CTCs as immunosuppression factor SCLC. Materials methods : In 30 patients stage III-IV SCLC, were using CellSearch system (Veridex LLC, Belgium) before treatment. The participants divided into groups based on Flow cytometry was used to assess T- natural...
УДК 616-006.66ОСОБЕННОСТИ ЛОКАЛЬНОГО КЛЕТОЧНОГО ИММУНИТЕТА ПРИ РАКЕ ОБОДОЧНОЙ КИШКИ В ЗАВИСИМОСТИ ОТ ЛОКАЛИЗАЦИИ ОПУХОЛЕВОГО ПРОЦЕССА Кит О.И. 1 , Дженкова Е.А. Мирзоян Э.А. Сагакянц А
to define some clinical characteristics of synchronous and metachronous colorectal cancer (CRC).The investigation was concerned with the data 150 patients T1-4N0-2M0-1 multiple primary CRC. The clinical, biological, morphological tumors were analyzed.Multiple 6.01% all cases There a preponderance CRC (63.75%) tumor localized in sigmoid colon rectum. In women, more often concurrent breast tumors; ones detected after treatment for genital tumors. men, frequently kidney cancer; identified...
BACKGROUND. Study of oncobiological aspects such a phenomenon as multiplicity primary colorectal tumors, well improvement methods their treatment is relevant nowadays. The aim the study was to reveal potential minimally invasive surgery for multiple cancer. MATERIAL AND METHODS. Data on 51 patients with synchronous cancer were studied. Clinical, biological and morphological characteristics ofsynchronous tumors analyzed. 12 underwent surgeries colon rectum - laparoscopy transanal endoscopic...
We analyzed literature data and our results of preoperative radiotherapy for 179 patients with resectable rectal cancer T2-4N0-2M0. The purpose the study was to analyze complete clinical response chemoradiotherapy cancer. showed advantages monitoring before total mesorectumectomy: no complications deaths after surgery; absence a syndrome low anterior resection rectum dysfunction pelvic organs; intestinal stoma rates; similar overall survival patients. problems associated “Watch Wait” tactics...
Adenoid cystic carcinoma of the lung is a relatively rare malignant tumor, accounting for 0.04–0.2 % all primary tumors respiratory system. This can occur at any age, but it more common in 40–60 age group and usually women. The main treatment method adenoid surgical. Since this histological form are often centrally located, options bronchoplastic operations considered. In childhood, extremely rare, performing lobectomies children associated with several difficulties, such as smaller diameter...
Despite significant advances in the treatment of malignant neoplasms, issue therapy resistance mediated by cancer stem cells (CSCs) necessitates development new strategies. Studying role CSCs and immune microenvironment pathogenesis cancer, particularly non-small cell lung (NSCLC), is a pressing modern oncology. This paper based on an extensive analysis recent research aims to study mechanisms underlying NSCLC. The origin CSCs, their markers, main signaling pathways involved regulating...
The discovery of immune checkpoint inhibition has revolutionized the treatment many solid malignancies, including non-small cell lung cancer (NSCLC). Immune inhibitors (ICI) can restore antitumor response by blocking T-cell activation. Anti-programmed death-ligand 1 (PD-L1) is currently main biomarker effectiveness anti-PD-1 / PD-L1 blockade in NSCLC without driver mutations. High tumor mutational burden suggests an increased neoantigens load and been associated with ICI therapy....
The article presents a clinical case of pulmonary mucormycosis in 12‑year-old child at the stage diagnosis acute lymphoblastic leukemia. first symptoms disease (headaches, malaise and weakness, pallor), changes general blood count (hyperleukocytosis up to 200 thousand cells/μl, single platelets). Based on results examination, main was verified for leukemia L2, IFT T-II, CD1a-. At leukemia, underlying complicated by development right-sided pneumonia according X-ray examination. To verify...
Purpose of the study. To conduct a comparative analysis E-cadherin expression in inoperable patients with non-small cell lung cancer (NSCLC) cells and different survival rates. Materials methods. The study included 96 NSCLC: 84 (87.5 %) men 12 (12.5 women, whose average age was 62.4 ± 0.68 years. Squamous carcinoma (SCC) diagnosed 78 (81.25 patients, adenocarcinoma (AC) tumor differentiation grade G2-G3 18 (18.75 %). were treated monitored at National Medical Research Centre for Oncology....
Purpose of the study. This study aimed to identify characteristics course cell lung cancer (LC) and information content indicators adaptation status patients different sexes who had COVID‑19, confirmed by PCR diagnostic results before start antitumor treatment. Patients methods. We have studied traditional clinical laboratory parameters, white blood count in with non‑small LC st. I–III, men (59) women (32) aged 36–75 years. The main groups included 32 16 real‑time PCR, 2–9 months...
Thymomas and carcinomas of the thymus gland, also known as epithelial tumors (TT) are rare malignant neoplasms, but most common solid anterior mediastinum. The incidence does not exceed 1.3–1.7 per million inhabitants year. In Europe, about 1,500 new cases registered annually, average age patients is around 40–50 years. Originating from component thymus, primary lymphoid organ, they accompanied by a high risk developing autoimmune disorders due to their unique biology. Indeed, up 30 % TETS...
The role of redox processes imbalance in the onset malignant transformation and neoplasia progression is well known. It has been suggested that COVID-19 a metabolic disease. Reactive oxygen species (ROS) glutathione-dependent antioxidant system contribute much to its development. Moreover, there an opinion it necessary precisely identify free radical oxidation products status blood patients.
 purpose study evaluate intensity lipid peroxidation parameters cells lung cancer patients with...
More than 1.8 million of new cases lung cancer (LC) are registered each year worldwide. LC is the leading cause death in both developing and developed countries, 5 years survival rate as low 19 %. Many factors explain such unsatisfactory outcomes, including diagnosis at an advanced stage, when currently available treatments can rarely provide cure. Biomarkers used to assess development risks, screening, diagnosis, monitoring, prognosis, personalize treatment. Clinical use biomarkers...
Significant number of patients with early and locally advanced non-small cell lung cancer (NSCLC) develops relapses after surgical treatment. Effective medical therapy preventing in operable NSCLC is apparently still urgently needed. Immunotherapy immune checkpoint inhibitors has become the main treatment for progressive NSCLC. Neoadjuvant blockade well tolerated without causing excessive toxicity increased postoperative complications mortality rates. Phase II clinical trials have shown...
Purpose of the study . To evaluate number cells with CD45 +/- phenotype expressing Toll-like receptors (TLRs) in tissues tumor, peritumoral area and resection line colon cancer (CC) various tumor locations. Materials methods The included 50 patients CC. All underwent surgery as primary treatment, tissue material was collected from patients. Expression TLRs (2, 3, 4, 8, 9) on + , - cell populations determined by flow cytometry suspensions obtained (1–3 cm tumor) (~10 further calculation...
To analyze the problem of access conversion in laparoscopic surgery for colorectal cancer.There were 876 procedures cancer T14N01M0 performed at Rostov Research Institute Oncology 2015-2017. Open and was applied 562 309 patients, respectively. Conversion required 35 (10.2%) patients.Conversions 2.7 times more frequent men (p<0.05) (probably due to anatomical features - a narrow pelvis) predominantly with rectosigmoid (22.2%, 2 patients) rectal (12%, 22 patients). Conversions women as well...
e22026 Background: The purpose of the study was to analyze content and assess prognostic value CTCs in peripheral blood colorectal cancer patients with liver metastases. Methods: 75 resectable metastases Т2-4N0-1M1 (adenocarcinoma G2-G3), mean age 63.7±1.9 years, were recruited. Quantitative analysis performed using CellSearch Veridex System (Janssen) 10 days after colon surgery resection. registered taking into account morphologic characteristics expression epithelial cell adhesion markers...
e15530 Background: Peritoneal metastases are the most common recurrence of gastric cancer, even after radical surgery. Urokinase-type plasminogen activator (uPA) system, including its receptor uPAR, is crucial in proteolysis activation for cleavage extracellular matrix and basement membrane. The purpose study was to determine antigen form uPA-Ag, active uPA-act uPAR tissues adenocarcinoma stomach, perifocal (PT), greater omentum peritoneum patients with stomach cancer T 3-4 а N 0-3 M 1 0 ....
e15079 Background: Initially, berberine was used as an antimicrobial agent in traditional medicine, but its anticancer properties were later discovered. In addition to cytotoxic effect, also has the ability inhibit cell motility, which been demonstrated some permanent cancer lines. The objective of this study assess anti-migratory activity cultures compared primary are generally thought better reflect tumor characteristics. Methods: H1299 lung cancer, PC3 prostate and T98G glioma cells, well...
e20513 Background: Currently, an active search is underway for additional markers that predict the risk of tumor progression based on epithelial-mesenchymal transition (EMT). Desmocollin 3 (DSC 3), a member Cadherin superfamily and cell adhesion marker, one this transition. The aim our study was to evaluate expression DSC as prognostic factor in different subtypes non-small lung cancer. Methods: included 12 patients with squamous cancer 8 adenocarcinoma, aged 49 76 years. Immunohistochemical...
Lung cancer (LC) takes the first place in structure of overall oncology males. More than 1.8 million new cases lung are registered each year worldwide. LC is leading cause death both developing and developed countries, 5 years survival rate as low 19 %. Many factors explain such unsatisfactory outcomes, including diagnosis at an advanced stage, when currently available treatments can rarely provide cure. Non-small cell (NSCLC) with chromosomal rearrangement anaplastic lymphoma kinase (ALK)...
Increasing life expectancy is the goal of social programs in Russian Federation as a reflection success public health. Globally, there trend for aging population, contributing to an increased risk lung cancer developing which primarily disease elderly. Chronologic age or performance scores alone are not accurate predictors patients’ capacity tolerating aggressive therapies. Use comprehensive geriatric assessment determine treatment strategy able reduce toxicities and failures. Safe elderly...