A5053744959- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Virus-based gene therapy research
- Cancer Research and Treatments
- Viral gastroenteritis research and epidemiology
- Inflammatory Biomarkers in Disease Prognosis
- Bladder and Urothelial Cancer Treatments
- Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- HER2/EGFR in Cancer Research
- Immune cells in cancer
- Gastric Cancer Management and Outcomes
- Immunotherapy and Immune Responses
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Monoclonal and Polyclonal Antibodies Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Drug Transport and Resistance Mechanisms
- Reconstructive Surgery and Microvascular Techniques
- Sarcoma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Cancer, Stress, Anesthesia, and Immune Response
- Breast Implant and Reconstruction
- Esophageal Cancer Research and Treatment
Ministry of Health of the Russian Federation
2020-2023
Rostov Research Institute of Oncology
2015-2022
Purpose of the study. To study local immunity and cytokine levels in colon cancer patients with subcompensated intestinal obstruction. Patients methods. In 60 locally advanced left-side carcinoma (30 30 without bowel obstruction) during surgery samples tumor, peritumoral area resection line tissue were obtained. After disintegration Т-, В-, NK-lymphocytes` subsets (CD3+, CD4+, CD8+, CD4+CD25+CD127dim, CD19+, CD16+CD56+) studied by flow cytometry inflammatory cytokines` content (TNF-α, IL-1α,...
Cancers and diabetes mellitus are among the most common human pathologies, with an increase in morbidity every year. To this date, a relationship of type 2 (DM2) increased risk development progression cancer many localizations has been established, nevertheless data on impact DM2 course bladder contradictory. Objective. study features expression angiogenic proteins — vascular endothelial growth factor (VEGF) platelet cell adhesion molecule (CD31), to evaluate their gender specificity...
The aim of our study is to assess the local cytokine levels as prognostic factors for early relapse in NMIBC patients. 75 patients with were enrolled study: 51 primary and 24 initially recurrent NMIBC, LG HG tumors diagnosed each group. Patients monitored during 9 months after treatment: TURB chemotherapy (No. 6). During samples taken, supernatants obtained tissue measured (IL-1β, IL-6, IL-10, IL-18, TNFα, IFNγ, IL-8) by ELISA test. results showed that relapses 15 (46.8%) 11 (45%) matching...
Purpose of the study. Determine content cancer stem cells (CSCs) in tumor tissue (TT) and perifocal tissues (PT) muscle-non-invasive bladder cancer. Materials methods. We’ve examined fragments TT PT 7 (NMIBC) after surgical intervention – transurethral resection urinary (TUR). In samples that were used to obtain cell suspension using BD Medimachine apparatus (BD, USA) was treated with monoclonal antibodies CD45-APCCy7, CD44-FITC, CD133-РЕ, CD24-PE assessed on flow cytometer FacsCantoII USA)....
ДИНАМИКА ЦИТОКИНОВОГО ПРОФИЛЯ КРОВИ БОЛЬНЫХ С МЕТАСТАТИЧЕСКИМ КОЛОРЕКТАЛЬНЫМ РАКОМ ПРИ ПРОВЕДЕНИИ анти-EGFR ТЕРАПИИКит О.И., Владимирова Л.Ю
Aim. To analyze the expression of p53 and Ki67 markers in patients with stage IIIC-IV ovarian cancer by immunohistochemical (IHC) method as a criterion for treatment effectiveness. Materials Methods. The study included 93 aged 34-77 years. were divided into 4 groups: group 1 – neoadjuvant chemotherapy intramuscular injections recombinant interferon-gamma; 2 intraperitoneal 3 (controls) standard without (comparison group) surgery first treatment. All tumor samples studied IHC protein Кi-67...
e21067 Background: The purpose of the study was to analyze expression angiogenesis-controlling markers (CD31, VEGF) in tissues melanocytic skin lesions. Methods: included 20 patients with benign pigmented lesions and 15 superficial spreading nodular melanoma. Immunohistochemical performed on sections paraffin blocks for standard morphological studies using murine monoclonal CD31 VEGF antibodies. UltraVision Quanto Detection System HRP DAB used visualization. Angiogenesis tumors assessed by...
e21068 Background: Lung cancer (LC) is one of the most commonly diagnosed cancers and leading causes death worldwide. A limited clinical benefit checkpoint inhibitor therapy (CIT) remains an important issue. Various units immune system are involved in both antitumor immunity development CIT-induced side effects. Cytokines play a special role these phenomena. The purpose this study was to evaluate cytokine profiles peripheral blood patients with non-small cell lung (NSCLC) receiving CIT....
Цель. Исследовать зависимость количества циркулирующих опухолевых клеток в периферической крови у больных колоректальным раком от клинико-морфологических характеристик основного заболевания.
 Методы. В исследование был включён 91 пациент с верифицированным метастатическим Т3-4N1-2М1. Средний возраст составлял 61,5±1,7 года. Пациенты были разделены на основную группу (лапароскопическое хирургическое лечение, n=44) и контрольную (хирургическое вмешательство открытым доступом, n=47). Число...
Background . Gastric cancer is the second leading cause of cancer-related death due to advanced disease. A special role in pathogenesis and metastasis tumor assigned stem cells (TSC ), responsible for resistance chemotherapy radiotherapy causing progression. Objective : determine CD 44 133 markers TSC tissues non-metastatic metastatic gastric using immunohistochemical method. Material Methods prospective study tumors patients with was conducted: Group 1 – 20 people T3–4aN0–3M0G2 tumor,...
ИММУННЫЙ СТАТУС БОЛЬНЫХ РАКОМ ШЕЙКИ МАТКИ ПРИ ЛЕЧЕНИИ С ПРИМЕНЕНИЕМ ДЕНДРИТНО-КЛЕТОЧНОЙ ВАКЦИНАЦИИМеньшенина А.П. 1 , Златник Е
e15531 Background: High incidence and mortality rates of gastric cancer cause a constant search for the most informative effective methods diagnosis treatment assessment. In this regard, studying expression markers with stem phenotype in primary tumor tissues patients without metastases is undoubted interest. Methods: The study included 20 aged 30-80 years: group 1 – T3-4аN0-3M0 (G2) metastasis (58.9±9.7 years); 2 T3-4аN0-3M1 peritoneal (53.4±11.9 years). Immunohistochemical was performed on...
e23545 Background: The tumor ability to induce and maintain angiogenesis is one of the main stages its development. Studies molecular mechanisms showed that dynamic balance ensures formation development new vessels inside depends on pro- anti-angiogenic factors. VEGF CD34 endothelial cell marker are considered among activators angiogenesis. Our purpose was study characteristics in primary recurrent soft tissue sarcomas. Methods: included 30 patients with sarcomas (group 1) 26 2). Sections...
e16073 Background: The purpose of the study was a correlation analysis parameters local immunity and markers epithelial-mesenchymal transition (EMT) with number circulating tumor cells (CTCs) in patients stage II-IV colorectal cancer (CRC). Methods: included 60 newly diagnosed CRC. CTCs were detected Cell Search System (Janssen Diagnostics, LLC) prior to surgery. CTC≤3 considered negative, CTC > 3 – positive. After surgery, IHC infiltration immune system performed monoclonal antibodies...
ЭКСПРЕССИЯ МАРКЕРОВ ОПУХОЛЕВЫХ СТВОЛОВЫХ КЛЕТОК В РЕГИОНАЛЬНЫХ И ДИСТАНТНЫХ МЕТАСТАЗАХ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫСагакянц А.Б
КОРРЕЛЯЦИОННЫЙ АНАЛИЗ ПОКАЗАТЕЛЕЙ ЛОКАЛЬНОГО ИММУНИТЕТА И ЭПИТЕЛИАЛЬНО-МЕЗЕНХИМАЛЬНОГО ПЕРЕХОДА БОЛЬНЫХ КОЛОРЕКТАЛЬНЫМ РАКОМ В ЗАВИСИМОСТИ ОТ УРОВНЯЦИРКУЛИРУЮЩИХ ОПУХОЛЕВЫХ КЛЕТОК Ситковская А.О. 1 , Новикова И.А. Златник Е.Ю. Ульянова Е.П. Шульгина О.Г. Колесников В.Е. Габричидзе П.Н. Донцов В.А. Мезенцев С
Purpose of the study. Evaluation expression E- and N-cadherins in tumor tissues postmenopausal patients with primary operable luminal breast cancer (BC) without Her2/neu overexpression for inclusion panel a comprehensive assessment biological parameters disease prognosis. Patients methods. The study included 120 divided into two groups: A B subtypes. To evaluate prognostic significance N- cadherins both groups patients, we analyzed levels correlation using Mann- Whitney U-test Spearman...
The purpose was to study antitumor effects of the group K rotaviruses strains No. 228 and 100 in experiment on a model transplantable murine melanoma.
 Material methods. included 65 С57Black/6 mice with B16/F10 melanoma two Reoviridae family members characterized as rotaviruses, not belonging known groups, working title “group (RVK)”. Animals received RVK “vaccination” (before tumor transplantation) “treatment” (after formation) modes. Live inactivated were used. administered...
e20513 Background: Currently, an active search is underway for additional markers that predict the risk of tumor progression based on epithelial-mesenchymal transition (EMT). Desmocollin 3 (DSC 3), a member Cadherin superfamily and cell adhesion marker, one this transition. The aim our study was to evaluate expression DSC as prognostic factor in different subtypes non-small lung cancer. Methods: included 12 patients with squamous cancer 8 adenocarcinoma, aged 49 76 years. Immunohistochemical...
ПРЕДИКТОРНАЯ РОЛЬ ЛОКАЛЬНОГО УРОВНЯ ЦИТОКИНОВ В ТЕЧЕНИИ НИЗКОДИФФЕРЕНЦИРОВАННЫХ ГЛИАЛЬНЫХ ОПУХОЛЕЙЗлатник Е.Ю
3522 Background: Cancer stem cells (CSCs) capable of self-sustaining and multipotent differentiation are considered among the most important factors limiting treatment effectiveness. ALDH1 is a marker colorectal cancer (CRC) CSCs; it involved in cell proliferation, determines resistance to alkylating chemotherapeutic agents, also induces epithelial-mesenchymal transition (EMT), which increases invasive metastatic potential tumors. The purpose study was assess association between expression...
e17530 Background: Despite the progress made in diagnosis and treatment, ovarian cancer (OC) is still third most common genital cancer. Poor results of therapy for various forms OC stimulate search fundamentally new approaches to treatment. One main reasons resistance chemotherapeutic agents includes multidrug (MDR) tumor cells. The characterized its mechanisms elevated activity ABC family protein - ABCB1 (Pgp or MDR1). purpose study was evaluation expression this transporter as a predictive...
Nanotechnologies are significant modern trend embracing various fields of science including biology and medicine. Investigations biological activities nanoparticles (NP) suggest perspectives their application in oncology. The role metals metabolic processes the organism is well known, but a few data available about nanometals. Our aim was to study effect metallic on growth xenografts human lung cancer transplanted mouse tumors. Nanoparticles ultrasmall pulvers Zn, Cu, Fe (size 40–100 nm). NP...