A5103051256- Alzheimer's disease research and treatments
- Healthcare Systems and Public Health
- Cancer-related molecular mechanisms research
- Nuclear Receptors and Signaling
- Cholinesterase and Neurodegenerative Diseases
- Neurological Disorders and Treatments
- Psychology of Development and Education
- Neuroendocrine Tumor Research Advances
- Psychiatric care and mental health services
- Computational Drug Discovery Methods
- Neuroscience and Neuropharmacology Research
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Mental Health Treatment and Access
- Psychosomatic Disorders and Their Treatments
- Schizophrenia research and treatment
- Homicide, Infanticide, and Child Abuse
- Regulation of Appetite and Obesity
- Educational Methods and Teacher Development
- Personality Disorders and Psychopathology
- Colorectal Cancer Treatments and Studies
- Technology and Human Factors in Education and Health
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Retinoids in leukemia and cellular processes
- Human Health and Disease
Ryazan State Medical University named after Academician I.P. Pavlov
2015-2024
Hologic (Germany)
2023
Rostov Research Institute of Oncology
2018-2020
Peoples' Friendship University of Russia
2018
Universitat de Barcelona
2014-2017
Biomedical Research Networking Center on Neurodegenerative Diseases
2014-2016
Institut de Biomedicina de la Universitat de Barcelona
2014
Instituto Nacional de Neurología y Neurocirugía
2014
University Hospital Heidelberg
2006
Heidelberg University
2006
Alzheimer disease (AD) is a major neurodegenerative disorder which eventually results in total intellectual disability. The high global prevalence and the socioeconomic burden associated with pose challenges for public health 21st century. In this review we focus on both existing treatments therapies being developed, principally target β-amyloid protein. amyloidogenic hypothesis proposes that plays key role AD. Several pharmacological approaches aim to reduce formation of peptides by...
Alzheimer's disease (AD) is currently an incurable aging-related neurodegenerative disorder. Recent studies give support to the hypotheses that AD should be considered as a metabolic disease. The present study aimed explore relationship between hippocampal neuropathological amyloid-β (Aβ) plaque formation and obesity at early presymptomatic stage (3 months of age). For this purpose, we used APPswe/PS1dE9 (APP/PS1) transgenic mice, fed with high-fat diet (HFD) in order investigate potential...
A growing body of evidence suggests that β-amyloid peptides (Aβ) are unlikely to be the only factor involved in Alzheimer's disease (AD) aetiology. In fact, a strong correlation has been established between AD patients and with type 2 diabetes and/or cholesterol metabolism alterations. addition, link adipose tissue metabolism, leptin signalling particular, also demonstrated. present study we analyzed expression molecules related main focus on prolactin pathways an APPswe/PS1dE9 (APP/PS1)...
The article presents the results of studying clinical and social characteristics partially incapacitated disabled citizens in psychoneurological inpatient facilities; an assessment comprehensive work regional commission on possibility improving civil status patients is given.
Актуальность представленной публикации обусловлена стратегической задачей повышения эффективности правоохранительной работы по противодействию обороту незаконно заготовленной древесины до 2030 года в Российской Федерации. В целях внесения вклада ее решение автором проведено изучение современных тенденций преступности сфере лесопромышленного комплекса материалам Иркутской области и Красноярского края, 65–70 % территорий которых покрыты лесом. Исследование показало необходимость актуализации...
To date, eating disorders (anorexia nervosa, bulimia) have become widespread among the population. Alexithymia is considered to be one of main features patients with an disorder. In this regard, purpose study was identify and register components alexithymia in disorder, conceptually reflecting phenomenon. The research methods included: Toronto Alexithymic Scale (TAS-20), Lyusin Emotional Intelligence Test, Karpov Reflexivity Questionnaire, Giessen Questionnaire Somatic Complaints (GBB),...
INTRODUCTION: The article considers the impact of surgical intervention with subsequent exteriorization stoma on stress resistance level in patients colorectal cancer. AIM: To study dynamics and coping ability cancer before after (resection, stoma). MATERIALS AND METHODS: Stress was analyzed 30 aged 45 to 67 years (13 men 17 women) surgery exteriorization. following test methods were used: ‘Diagnostics ability’, ‘Life satisfaction index test’ (LSI), ‘Methodology diagnostics well-being,...
Рязанский государственный медицинский университет имени академика И.П.Павлова, Рязань, Российская Федерация (1) Российский дружбы народов
Рязанский государственный медицинский университет имени
e15081 Background: Colorectal cancer (CRC) is a common pathology in the world; annual incidence rate reaches 1 million cases, and mortality exceeds 500,000. The target therapy of EGFR with monoclonal drugs improves survival patients this pathology. However, effectiveness depends on presence mutations genes involved signaling cascade, particular KRAS. purpose study was to determine frequency somatic KRAS gene tumor samples from South Russia diagnosed colorectal cancer, as well analyze effect...
e16534 Background: The role of oxidative stress in tumor growth and the multifaceted functional significance glutathione have led to an interest studying components glutathione-dependent system gastric cancer (GC), which occupies a leading position incidence mortality. aim this work was study functioning red blood cells patients with comparative aspect depending on histotype prevalence disease. Methods: included 89 GC divided into 6 groups tumor. Separately, results were analyzed T4 status...