A5083101365- Cancer Treatment and Pharmacology
- Chemotherapy-induced cardiotoxicity and mitigation
- Advanced Breast Cancer Therapies
- Lung Cancer Treatments and Mutations
- Prostate Cancer Treatment and Research
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Metastasis and carcinoma case studies
- Genomic variations and chromosomal abnormalities
- Prostate Cancer Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Cancer-related cognitive impairment studies
- RNA modifications and cancer
- Hedgehog Signaling Pathway Studies
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Glutathione Transferases and Polymorphisms
- BRCA gene mutations in cancer
- Estrogen and related hormone effects
- Renal cell carcinoma treatment
- Sarcoma Diagnosis and Treatment
- Radiation Therapy and Dosimetry
Rostov Research Institute of Oncology
2019-2021
Aim . To create a collection of plasma samples patients with brain tumors (BTs) for the development diagnostic microRNA (ribonucleic acid) panel glial tumors. Material and methods Plasma benign malignant BTs were obtained by double centrifugation whole blood then frozen at -75оС.Fifty-nine RNA isolated from analyzed next-generation sequencing (NGS). Results Currently, biobank contains 339 primary secondary 10 control group individuals (698 — 2 aliquots per individual), including 143 men 206...
e13504 Background: Numerous pharmacogenetic studies have led to the identification of genetic polymorphisms associated not only with development cardiovascular disease, but also increase risk complications due use anthracycline drugs, widely used in treatment cancer. The purpose this study was assess prevalence rs28714259 polymorphism and possible correlation anthracycline-mediated cardiotoxicity (AMC). Methods: included 173 Caucasian patients (median age 55 years) a diagnosis breast cancer...
e15081 Background: Colorectal cancer (CRC) is a common pathology in the world; annual incidence rate reaches 1 million cases, and mortality exceeds 500,000. The target therapy of EGFR with monoclonal drugs improves survival patients this pathology. However, effectiveness depends on presence mutations genes involved signaling cascade, particular KRAS. purpose study was to determine frequency somatic KRAS gene tumor samples from South Russia diagnosed colorectal cancer, as well analyze effect...
Radioresistance of prostate cancer is a complex therapeutic problem. Biochemical recurrence after radiation therapy occurs in 22–69% patients with cancer. Nearly half these progress to clinical relapse within 15 years, and third castration-resistant This review analyzes literature data on radioresistance mechanisms cells. We searched for published eLibrary, PubMed, Scopus databases by key words: cancer, radioresistance, markers. In total, 568 foreign 178 national articles between 1975 2020...
e20542 Background: Lung cancer is the most common malignant tumor after breast and main cause of mortality. Mutations in EGFR gene typical lung lead to constitutive activation epidermal growth factor receptor cell transformation. The purpose this study was identify associations between double triple mutations clinical pathological characteristics patients South Russia diagnosed with cancer. Methods: DNA extracted from FFPE samples 240 patients. were detected using Cobas Mutation Test...
ИССЛЕДОВАНИЕ ГЕНЕТИЧЕСКИХ ПОЛИМОРФИЗМОВ, АССОЦИИРОВАННЫХ С РАЗВИТИЕМ АНТРАЦИКЛИН-ОПОСРЕДОВАННОЙ КАРДИОТОКСИЧНОСТИ, У ПАЦИЕНТОК ОНКОПАТОЛОГИЕЙ МОЛОЧНОЙ ЖЕЛЕЗЫ Гвалдин Д.Ю. 1 , Омельчук Е.П. Новикова И.А. Ратиева А.С. Ващенко Л.Н. Тимошкина Н
Abstract Background Genetic predisposition is one of the risk factors for development multiple primary cancers (MPCs), frequency which increases and ranges from 2 to 17%. This study describes a combination rare mutations, rs746551843 in NOTCH2 gene rs144933006 SDK2 gene, woman with breast cancer leiomyosarcoma without clearly burdened family history. Case presentation A 55-year-old Caucasian received complex treatment on basis National Medical Research Centre Oncology left soft tissues...
e16108 Background: The specialists consider partial nephrectomy (PN) under warm ischemia (WI) as a standard treatment option for localized renal cell carcinoma (RCC) patients. However, clinical use of the method is restricted by acute kidney injury (AKI) development among patients with high R.E.N.A.L. score, which usually demands long time (WIT). purpose study consists in assessing diagnostic ability cystatin С, IL-18, KIM-1, L-FABP and NGAL express-diagnosing AKI cancer after PN WI....
e23525 Background: Gastrointestinal stromal tumors (GIST) are rare malignant mesenchymal neoplasms of the gastrointestinal tract, diagnosis and treatment which is associated with presence mutations in c-KIT PDGFRA genes. Purpose this study was molecular genetic genotyping GIST according to clinically significant exons Methods: The included patients an immunohistochemically confirmed who underwent RRIO, Rostov-on-Don, for period 2018-2019 (n = 20, median age 63.5 years, men/women–10 people...
ПОКАЗАТЕЛЬ КОПИЙНОСТИ ГЕНОВ И УСТОЙЧИВОСТЬ ОПУХОЛЕВЫХ КЛЕТОК РАЗНЫХ НОЗОЛОГИЙ К ОБЛУЧЕНИЮГусарева М.А
12005 Background: Numerous pharmacogenetic studies have led to the identification of genetic polymorphisms associated not only with development cardiovascular disease, but also increase risk complications due use anthracycline drugs, widely used in treatment cancer. The purpose this study was frequency rs4673 and rs28714259 possible associations changes patients breast cancer during therapy (anthracycline-mediated cardiotoxicity — AMC). Methods: included 256 Caucasian (median age - 55 years)...