A5049877954- Colorectal Cancer Treatments and Studies
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Advanced Breast Cancer Therapies
- Renal cell carcinoma treatment
- HER2/EGFR in Cancer Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Brain Metastases and Treatment
- Head and Neck Cancer Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Genomics and Diagnostics
- Multiple and Secondary Primary Cancers
- Pancreatic and Hepatic Oncology Research
- Radiopharmaceutical Chemistry and Applications
- Viral-associated cancers and disorders
- Russian Literature and Bakhtin Studies
- Cancer Research and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Immunotherapy and Immune Responses
- Hematological disorders and diagnostics
Ministry of Health of the Russian Federation
2017-2023
Gorky Institute of World Literature
2016-2023
Russian Academy of Sciences
2016-2023
Rostov Research Institute of Oncology
2014-2022
City Clinical Oncology Center
2019-2022
Peoples' Friendship University of Russia
2020
Liver neoplasms are problematic among small domestic animals. The etiological cause of hepatocellular carcinomas in animals is still unknown although it believed that chronic infections and toxic substances can affect the development this type tumor. This study aimed to analyze clinical morphological characteristics canine carcinoma.In total, 6,958 cancer operations were performed clinic. tumors detected 123 dogs vivo 375 postmortem. All with suspected liver neoplasm assessed, including...
Abstract Background Real‐world data describing outcomes of treatment among metastatic renal cell carcinoma (mRCC) patients are limited and heterogeneous. Aim RENSUR3 registry study assessed real‐world on the use therapies in mRCC overall survival (OS) Russia, Kazakhstan, Belarus. Methods Patients were included retrospective multicenter study. To be eligible, required to have diagnosed from January 2015 2016. Anonymized collected through an online registry. The interest patient...
Background. Overall survival (OS) data obtained in patients with metastatic renal cell carcinoma (mRCC) real-world settings are rarely published. The objective of the RENSUR3 registry study was to collect information on use various therapeutic options for mRCC clinical practice and assess OS a Russian population. Methods . Patients were retrospectively identified at 8 cancer centres different regions enrolled if diagnosis had been made period from January 2015 December 2016. Anonymous...
Introduction . Erythropoietin (EPO) application is a pathogenetic method for anemia correction in cancer patients. The purpose of study Clinical evaluation the efficacy and safety Eralfon® (epoetin alpha) treatment patients with malignant solid tumors during medical anticancer therapy. Materials methods We analyzed data on 184 receiving various therapies. was injected subcutaneously 12 000 IU 3 times per week or 40 once week. antianemic effect, time to maximum adverse events (AE) were...
Purpose of the study . An analysis changes in expression VEGF neoangiogenic factor tumor tissue patients with squamous cell carcinoma oral mucosa receiving targeted therapy cetuximab and chemotherapy. Patients methods We performed an immunohistochemical samples obtained from 60 T3-4N0-1M0. The main group comprised 30 who received cisplatin fluoruracil plus cetuximab. control included standard chemotherapy without therapy. Each was divided into two subgroups different treatment efficacy:...
Background. Data on the overall survival (OS) of patients with metastatic bladder cancer (BCa) is rarely published. The objective URRU register study to assess OS and collect information administration different treatments in BCa routine clinical practice Russia. Materials methods . Patients were retrospectively identified 9 oncology centers regions Russia included if they diagnosed between January 2017 2018. We collected anonymized data online, including demographic characteristics...
The article shows the experience of eribulin application in actual clinical practice Oncology institutions Russian Federation concerning metastatic breast cancer. We have analyzed efficacy drug case different subtypes tumor and chosen patients, depending on location metastases with proven maximum eribulin. shown side reactions possibility combination other antineoplastic agents.
Background . Breast cancer is one of the most common malignancies and leading causes deaths among women in Russian Federation. The prognosis disease largely determined by biological subtype tumor. Her2-positive breast characterized an aggressive course unfavorable prognosis. use pertuzumab, a recombinant humanized monoclonal antibody to human epidermal growth factor receptor 2, significantly improved immediate long-term treatment outcomes. aim study was evaluate outcomes patients with...
The article discusses the intermedial transfer of concept polyphony in Mikhail Bakhtin’s and Leo Spitzer’s studies Dostoevsky Proust from late 1920s. There are plenty good reasons to compare two scholars’ works. Firstly, stylistics was key importance Bakhtin throughout his scientific career. Secondly, there is a correlation between methods for studying Proust’s Dostoevsky’s novels, which considered as pinnacle European Russian novel, respectively. stylistic revolution novel anticipated not...
Введение. Применение таргетного препарата рамуцирумаба — ингибитора сосудистого эндотелиального фактора роста 2 типа (VEGF2), в комбинации с химиотерапией (ХТ) паклитакселом/FOLFIRI является стандартом лечения второй линии больных метастатическим раком желудка. Описание случая. Больной, 72 лет, диссеминированным желудка (дРЖ) и отягощенным кардиологическим диагнозом, получает во последующей таргетную терапию рамуцирумаом ХТ иринотеканом последующим переходом на паклитаксел (суммарно 45...
Введение. Применение таргетного препарата рамуцирумаба — ингибитора сосудистого эндотелиального фактора роста 2 типа (VEGF2), в комбинации с химиотерапией (ХТ) паклитакселом/FOLFIRI является стандартом лечения второй линии больных метастатическим раком желудка. Описание случая. Больной, 72 лет, диссеминированным желудка (дРЖ) и отягощенным кардиологическим диагнозом, получает во последующей таргетную терапию рамуцирумаом ХТ иринотеканом последующим переходом на паклитаксел (суммарно 45...
e21068 Background: Lung cancer (LC) is one of the most commonly diagnosed cancers and leading causes death worldwide. A limited clinical benefit checkpoint inhibitor therapy (CIT) remains an important issue. Various units immune system are involved in both antitumor immunity development CIT-induced side effects. Cytokines play a special role these phenomena. The purpose this study was to evaluate cytokine profiles peripheral blood patients with non-small cell lung (NSCLC) receiving CIT....
Although melanoma is one of the most immunogenic tumors, it has an ability to evade anti-tumor immune responses by exploiting tolerance mechanisms. The extensively studied checkpoints represent cytotoxic T lymphocyte-associated protein‑4 (CTLA‑4) and programmed cell death protein‑1 (PD‑1). Immune checkpoint inhibitors (ICI), which were broadly applied for treatment in past decade, can unleash result regression. Patients responding ICI showed long-lasting remission or disease control status....
ПРОБЛЕМА ПАМЯТИ И ЗАБВЕНИЯ: М. БАХТИН О
e14577 Background: Topoisomerase I inhibitor Irinotecan (IT) is applied in CT for CRC. However, its toxicity associated with polymorphism of TATA box (T-thymine, A-adenine) the UGT1А1 gene limits use. Polymorphism UGT1A1*28 allele induces an increase TA sequence promoter from 6 to 7. It inhibition transcriptional activity and expression which results reduction enzyme activity, time SN-38 excretion IT toxicity. Methods: The study included pts histologically verified CRC, ECOG ≤ 2, normal...
e14002 Background: Clinical manifestations of herpesvirus infections are often non-specific and is a problem to differentiate it from the reactions CT. The study was performed analyze immunological markers induced by HSV 1.2, CMV, EBV, HHV6 HHV8 activation during CT solid tumors. Methods: patients who received for histologically verified metastatic tumors recruited in study. Blood samples were collected before after Antibodies viral proteins determined ELISA: IgM IgG HSV1.2, HHV6, HHV8....
Clinical data on the efficacy and safety of cetuximab panitumumab in 87 patients 1-4 lines drug therapy for metastatic colorectal cancer (mCRC) with wild-type RAS without surgical removal metastases were analyzed. Anti-EGFR drugs prescribed first line 64.4%, second - 14.9%, third 13.8% 6.9% fourth line. 14.9% continued anti-EGFR after progression during 2-3 (with change cytostatics). The use treatment mCRC was shown to provide satisfactory results overall survival rate progression-free...
The development of a new direction in anticancer medical therapy – the use immune checkpoint inhibitors targeting PD-1/ PD-L1 and CTLA-4 has significantly changed approach to tumor treatment last few years. PD1 blocker nivolumab major registered clinical trials improved overall survival, including metastatic melanoma, with favorable toxicity profile. However, its efficacy patients brain metastases from melanoma was poorly studied, since inclusion criteria for most do not envisage recruiting...
Parameters of ploidity and kinetics cell cycle in bone marrow samples lymphoma patients were studied by flow cytometry. These parameters compared to the prognostic criteria: disease stage, levels lactate dehydrogenase, sed rate test, B-symptoms, Bcl-2, Ki-67 etc. Analysis results shows, that lesions primary tumors are characterized a statistically significant increase Bcl2-expressing cells percentage G0-1 stage cycle, as well decrease G2М S stages proliferative pool S+G2M, (G2M+S) /...
e18098 Background: The impact of viral infections tumor tissues on the effectiveness antitumor treatment in patients with laryngeal cancer is poorly studied. Methods: Tumor 26 histologically confirmed squamous cell carcinoma larynx (SCCL) were All received neoadjuvant chemotherapy (CT) prior to laryngectomy: 12 pts - cetuximab+cisplatin+5-fluorouracil, 14 same regimen without cetuximab. Fibrolaringoscopy was used assess CT results. DNAs herpes simplex virus type 1,2 (HSV1,2), cytomegalovirus...
e12589 Background: Better efficiency and safety of Nab-P is known to be due the advantages pharmacokinetics pharmacodynamics drug. The fraction unbound paclitaxel in plasma 2.6-fold higher with than P. purpose study was assess efficacy ≥2nd lines chemotherapy (CT) patients (pts) mBC VC. Methods: Inclusion criteria: VC, ≥ 2 line CT, HR+, HER2neu+ or triple negative type (TN), normal liver renal function. Pts received 260 mg/m q 21 days. Her2/Neu + trastuzumab 6 mg/kg Results: 32 pts, mean age...
Objective: to analyze the frequency of metastasectomy in general population patients with RAS wild-type metastatic colorectal cancer who received chemotherapy and anti-EGFR monoclonal antibodies Materials methods . This prospective, non-randomized, multicenter study was designed evaluate resections organs affected by metastasis. Our statistical hypothesis that addition should increase from 5% 15 %. Sample size calculations showed obtain a power 80 % an alpha level 0.05 detect difference, we...