A5075240769- Breast Implant and Reconstruction
- Cancer, Hypoxia, and Metabolism
- Reconstructive Surgery and Microvascular Techniques
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Cancer Treatment and Pharmacology
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Immunotherapy and Immune Responses
- Cutaneous Melanoma Detection and Management
- Immune Cell Function and Interaction
- Management of metastatic bone disease
- Cancer Cells and Metastasis
- Redox biology and oxidative stress
- Mitochondrial Function and Pathology
- Protein Degradation and Inhibitors
- Endometriosis Research and Treatment
- Prostate Cancer Treatment and Research
- Computational Drug Discovery Methods
- Economic and Technological Systems Analysis
- Innovative Microfluidic and Catalytic Techniques Innovation
- 3D Printing in Biomedical Research
- Histone Deacetylase Inhibitors Research
- Synthesis of Organic Compounds
Rostov Research Institute of Oncology
2019-2024
Ministry of Health of the Russian Federation
2020-2022
СОДЕРЖАНИЕ ФАКТОРОВ РОСТА И ИХ РЕЦЕПТОРОВ В ОБРАЗЦАХ ОПУХОЛИ, ПЕРИФОКАЛЬНОЙ ЗОНЕ ЛИНИИ РЕЗЕКЦИИ У БОЛЬНЫХ БАЗАЛЬНОКЛЕТОЧНЫМ РАКОМ КОЖИ Бандовкина В.А. 1 , Франциянц Е.М. Ларина Н.И. Пржедецкий Ю.В. Каплиева И.В. Погорелова Ю.А
Purpose: This article considers the relevance of healthcare modernization processes in Russia terms marketing activities activation, public-private partnerships intensification.Design/Methodology/Approach: The problem ensuring security when government and institutions interact by means blockchain technologies is under-explored requires further research investigation.Therefore, methods induction, deduction, problem, system logical analysis along with economic process modelling method combined...
Aim: comparative analysis of plasmin, plasminogen (PG), urokinase PG activator (uPA) and its receptor (uPAR) in tissues malignant tumors intact skin С57ВЬ/6 mice both genders В16/F10 melanoma reproduced chronic neurogenic pain (CNP). Methods: The study was performed on 130 В16/ F10 cell line. Levels uPA-antigen (uPA-AG) uPA-activity (uPA-act), uPAR, PG, PAP (plasmin-a2-antiplasmin complex) were determined by ELISA. Statistics: the Statistica 10 program. Results. CNP-induced depletion content...
Topicality. An increase in the incidence of malignant tumors progressing against background various comorbid pathologies determines need to study mutual influence pathological processes using experimental modeling. Such models, for example, can reproduce tumor growth modified by condition diabetes mellitus, rate which is now increasing exponentially. In this case, a clear demonstration changes structure organs outside zone primary node, data on direct and content markers therein perifocal...
Background . Breast cancer is one of the most common malignancies and leading causes deaths among women in Russian Federation. The prognosis disease largely determined by biological subtype tumor. Her2-positive breast characterized an aggressive course unfavorable prognosis. use pertuzumab, a recombinant humanized monoclonal antibody to human epidermal growth factor receptor 2, significantly improved immediate long-term treatment outcomes. aim study was evaluate outcomes patients with...
studying AIF levels in mitochondria cells of the heart and various organs female mice with growth experimental melanoma B16 / F10 comorbid pathology
Purpose of the study . To intensity lipid peroxidation (LPO) and activity antioxidant protection components in tumor tissues, peritumoral zone conditionally healthy skin tissue basal cell carcinoma, depending on type growth, gender patients, presence concomitant diseases. Materials methods. Tissues from 34 patients with carcinoma (BCC) were studied, including 17 women (10 superficial growth 7 solid growth) men (5 12 respectively). We used flaps obtained during operations 10 without malignant...
Introduction . The choice of treatment between extracranial stereotactic radiotherapy and surgery for metastatic vertebral body tumors with minimum or no epidural compression the dura mater is yet to be clearly defined. Materials methods. study enrolled 41 patients who received at National Medical Research Centre Oncology (Rostov-on-Don, Russia) from January 1, 2014 December 31, 2022. inclusion criterion was presence a tumor, minimal radicular infundibulum (ESCC 0–1b). Patients were divided...
Purpose of the study. To evaluate cellular, genomic (gene copy number) and transcriptomic expression) effects P.hybridus (L.) secondary metabolites when they affect HeLa cell line. Materials methods. The isolation from plant material its identification were carried out by preparative chromatography. composition was determined using mass spectrometric analysis, final verification structural formulas nuclear magnetic resonance at Department Natural Compounds, Faculty Chemistry Southern Federal...
Background . Among all the new methods and approaches, virotherapy with oncolytic viruses, both in combination immunotherapy without it, shows high efficiency various phases of clinical trials good tolerance by patients. Aim To study sensitivity some immortalized cancer cell lines to R-92 strain human reovirus characteristics at ultrastructural level. Materials The was carried out on HeLa, A549, U87MG. Cells were planted an amount 15 thousand per well a 96-well plate after adhesion, virus...
In modern experimental oncology, 3D cell cultures have become particularly important, as they provide more relevant results compared to traditional 2D cultures. The problem of obtaining models remains urgent for the study breast cancer. One most common techniques a culture is hanging drop method. Researchers are constantly developing its modifications reduce variations in shape and size resulting spheroids. ways solve this apply hydrophobic coating surface plastics. Silicones or Parafilm®...
Purpose of the study . Evaluation antioxidant status and DNA damage in tissues subcutaneous xenografts non-small cell lung cancer peritumoral created using A549 H1299 cultures. Materials methods The included 35 intact male Balb/c Nude immunodeficient mice. Cell lines were used as transplantable tumor biomaterial. A CDX model was accordance with protocol for supratentorial injections (Ozawa T., James C. D., 2010) adapted this experiment. Growth rates controlled intracranial visualized a...
<h3></h3> Протезирование молочной железы после мастэктомии по поводу рака (РМЖ) является важным реабилитационным этапом при этом заболевании. В осложнениях, развивающихся имплантации протезов, может играть роль состояние иммунной системы больных. работе исследованы показатели клеточного иммунитета в раневой и аксиллярной жидкости 46 больных РМЖ течение 7 дней текстурированного имплантата (ТИ) или полиуретанового (ПУИ). периферической крови, а также раневом отделяемом из полости с различными...
УДК 601.2 ОБЗОР СОВРЕМЕННЫХ МЕТОДОВ КРИОКОНСЕРВАЦИИ РАЗЛИЧНЫХ ВИДОВ БИОЛОГИЧЕСКОГО МАТЕРИАЛА Заикина Е.В. 1 , Гончарова А.С. Позднякова В.В. Пандова О.В. Пржедецкий Ю.В. Воловик В.Г. 2 Карасев Т.С
e22084 Background: Gender is an important independent prognostic factor for cutaneous melanoma incidence, and survival in women better. The purpose of the study was to determine content sex steroids prolactin tumor, perifocal resection line tissues male female patients with melanoma. Methods: included 13 men 22 (M) pT 1-2 N 0 M . Levels free testosterone (fT), estradiol (E2), estrone (E1), progesterone were measured by ELISA M, (P) (RL) after surgical treatment. average age 54±3.56 years...
НЕКОТОРЫЕ ОСОБЕННОСТИ ГУМОРАЛЬНОГО ИММУНИТЕТА И ЦИТОКИНОВОГО СТАТУСА ПРИ АЛЛОМАММОПЛАСТИЧЕСКИХ ОПЕРАЦИЯХ У БОЛЬНЫХ РАКОМ МОЛОЧНОЙ ЖЕЛЕЗЫПржедецкая В.Ю
Purpose of the study. Was to reveal characteristics immunocompetent cells in colon cancer (CC) according disease stage, and identify prognostic factors development. Materials methods . The study included 50 patients with CC: stage I – 4 (8 %), II 25 (50 III 21 (42 %). All underwent standard surgical intervention at initial obtained material was used for subsequent studies: a cell suspension from tumor tissue, peritumoral zone (1–3 cm tumor), which treated an antibody panel (Becton Dickinson,...
Purpose of the study. Was to reveal characteristics immunocompetent cells in colon cancer (CC) according disease stage, and identify prognostic factors development. Materials methods . The study included 50 patients with CC: stage I – 4 (8 %), II 25 (50 III 21 (42 %). All underwent standard surgical intervention at initial obtained material was used for subsequent studies: a cell suspension from tumor tissue, peritumoral zone (1–3 cm tumor), which treated an antibody panel (Becton Dickinson,...
ИЗУЧЕНИЕ ПРОТИВООПУХОЛЕВОГО ВЛИЯНИЯ ИНГИБИТОРА WNT-ПУТИ XAV-939 НА МОДЕЛИ ТРОЙНОГО НЕГАТИВНОГО РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ IN VIVOЛяшенко И.С
e22103 Background: Chronic neuropathic pain (CNP) demonstrates the ability to stimulate tumor growth and neoangiogenesis. Our purpose was study VEGFA levels in of B16/F10 melanoma with CNP mice genetically determined inhibition growth. Methods: Females С57ВL/6 (normal genome (uPA+), n = 26) C57BL/6-Plautm1.1BugThisPlauGFDhu/GFDhu (urokinase gene knockout (uPA–), 16) received subcutaneous transplantation 2 weeks after bilateral sciatic nerve ligation (CNP model). After 3 carcinogenesis CNP,...
e22082 Background: Clusters of tumor cells in blood vessels secrete VEGF family factors necessary for the formation premetastatic niches. TGF-β activates epidermal-mesenchymal transition (EMT). The purpose study was to analyze levels angiogenesis and EMT patients with cutaneous melanoma (M) chronic neurogenic pain (CNP). Methods: Blood VEGF-A, VEGF-C, VEGFR-1, VEGFR-3, TGF-β1 TGF-βR2 were measured by ELISA Т 3-4 N x M 0 melanoma: 21 women CNP (pelvic - 7, osteochondrosis – 14), mean age...
e22109 Background: The plasminogen activation system and biogenic amines are involved in melanoma pathogenesis, but currently, the mutual influence of components these systems on each other is unknown. purpose study was to reveal dynamics brain intact tumorous skin (B16/F10 melanoma) C57BL/6-PlautmI.IBug-ThisPlau6FDhu/GFDhu mice with uPA gene knockout. Methods: included male female C57BL/6-PlautmI.IBug-This Plau6FDhu/GFDhu mice, n = 38; comparison group C57BL/6 without knockout, 61. Melanoma...
e22083 Background: The ability of malignant tumors to invasion and metastasis is associated with increased activity the plasmin/plasminogen family proteases. purpose study was analyze changes in system adjacent tissues patients cutaneous melanoma dependence on their gender. Methods: included 13 men 22 women pT 1-2 N 0 M . Levels plasmin (PAP), content uPA, tPA, PAI were determined by ELISA homogenates (M), perifocal (P) resection line (RL) after surgical treatment. All gave a voluntary...