A5007628683- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Chemical Reaction Mechanisms
- Synthesis and Biological Evaluation
- Organic Chemistry Cycloaddition Reactions
- Berberine and alkaloids research
- Molecular Sensors and Ion Detection
- Chemical Reactions and Mechanisms
- Photochromic and Fluorescence Chemistry
- Bioactive Compounds and Antitumor Agents
- DNA and Nucleic Acid Chemistry
- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Alkaloids: synthesis and pharmacology
- Synthesis and Reactions of Organic Compounds
- Crystallography and molecular interactions
- Phenothiazines and Benzothiazines Synthesis and Activities
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Synthesis and Characterization of Pyrroles
- Luminescence and Fluorescent Materials
- Porphyrin and Phthalocyanine Chemistry
- Chemical synthesis and alkaloids
- Synthesis and Biological Activity
- Fluorine in Organic Chemistry
- Synthesis of Organic Compounds
Southern Federal University
2016-2025
Institut Lavoisier de Versailles
2015
Southern Scientific Center
2013-2014
Russian Academy of Sciences
2013-2014
A. N. Nesmeyanov Institute of Organoelement Compounds
2012
The chemistry of heterocyclic compounds has traditionally been and remains a bright area chemical science in Russia. This is due to the fact that many heterocycles find widest application. These are key structural fragments most drugs, plant protection agents. Many natural also derivatives heterocycles. At present, more than half hundreds millions known collective review devoted achievements Russian chemists this field over last 15–20 years. presents leading heterocyclists representing both...
Azetidines fitted with a 3-hydroxypropyl side chain at the 2-position undergo intramolecular N-alkylation after activation of primary alcohol, and produced 1-azonia-bicyclo[3.2.0]heptane is opened by different nucleophiles (cyanide, azide, or acetate anions) to produce mixtures ring expanded pyrrolidines azepanes, unique type compound. Distribution five- seven-membered rings depends on substitution pattern azetidine its chain, together nature nucleophile used in expansion process. Observed...
We developed a microfluidic synthesis with UV-Vis diagnostics using 3D printed chip for 8,13-disubstituted berberines. This system yielded up to 30% higher product yields high antioxidant activity compared traditional batch synthesis.
The heterocyclic core of imidazo[1,2-a]pyrimidine was formed in satisfactory yields as a result the interaction readily available 2-aminoimidazole with N-substituted maleimides or N-arylitaconimides. mechanism studied processes postulated basing on experimental data, HPLC-MS analysis reaction mixtures, and quantum chemical calculations. Molecular docking results obtained imidazo[1,2-a]pyrimidines, when compared voriconazole, drug already clinical use, suggest that they may possess antifungal...
Two first representatives, 5 and 6, of the still unknown 4,5-bis(dimethylamino)quinoline have been synthesized studied. While former, being protonated either at peri-NMe(2) groups or ring nitrogen, has shown to display properties both a proton sponge azine, its counterpart 6 behaves exclusively as azine giving only quinolinium salt.
Unreported α-hydroxy-β-azido tetrazoles are prepared in a single step and mild conditions from readily available epoxy nitriles.
A new approach for the annulation of a thiopyrane ring to an indole core under mild conditions was developed. Treating 2-methyl-3-acylindoles with lithium diisopropyl amide leads elimination proton from 2-methyl group. The indole-2,3-dienolates obtained were found react CS2 give corresponding thiopyrano[4,3-b]indole-3(5H)-thiones. mechanism represents stepwise addition through ion-pair formation, according PCM/B3LYP/6-311++G**, PBE1PBE/6-311++G**, and MP2//HF/6-311++G** quantum chemical...
Abstract The viability of the oxidative alkylamination process for derivatization electron‐deficient carboaromatics has been investigated. 1,3‐Dinitrobenzene, 1‐nitronaphthalene, and 1,5‐ 1,8‐dinitronaphthalenes have shown to react with a wide range alkylamines in presence an oxidant (KMnO 4 , AgMnO AgPy 2 MnO ) give access corresponding N ‐alkyl‐nitroarenamines moderate good yields. Nitroarenes are more reactive than azines towards alkylamines.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451...
Abstract New quinoxaline 1,4‐dioxide derivatives have been synthesized from novel fluorinated benzofuroxans such as 4‐fluorobenzofuroxan, which is prepared for the first time. Furthermore, preparation 4,6‐difluorobenzofuroxan has revisited because we were unable to reproduce reported synthetic method. Several pathways thus investigated, and optimal way prepare this disubstituted benzofuroxan was 3,5‐difluoro‐2‐nitroaniline. The various attempts allowed isolation of interesting new compounds...