A5063448578- Synthesis and Characterization of Heterocyclic Compounds
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- DNA and Nucleic Acid Chemistry
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Surfactants and Colloidal Systems
- Supramolecular Chemistry and Complexes
- Drug-Induced Hepatotoxicity and Protection
- Cholinesterase and Neurodegenerative Diseases
- Chemical Reaction Mechanisms
- Pharmacological Effects of Natural Compounds
- Synthesis and biological activity
- Crystallography and molecular interactions
- Molecular Sensors and Ion Detection
- HIV/AIDS drug development and treatment
- Computational Drug Discovery Methods
- Antimicrobial agents and applications
- Pesticide Exposure and Toxicity
- Analytical Chemistry and Chromatography
- Chemical synthesis and pharmacological studies
- Molecular spectroscopy and chirality
- Synthesis of heterocyclic compounds
- Bacteriophages and microbial interactions
- Biochemical and Molecular Research
A.E. Arbuzov Institute of Organic and Physical Chemistry
2016-2025
Russian Academy of Sciences
2008-2023
Kazan State Technological University
2007-2023
Kazan Scientific Center
2016-2021
Kazan Federal University
1994-2008
University of Connecticut
2008
The chemistry of heterocyclic compounds has traditionally been and remains a bright area chemical science in Russia. This is due to the fact that many heterocycles find widest application. These are key structural fragments most drugs, plant protection agents. Many natural also derivatives heterocycles. At present, more than half hundreds millions known collective review devoted achievements Russian chemists this field over last 15–20 years. presents leading heterocyclists representing both...
Brain tumor glioblastoma is one of the worst types cancer. The blood–brain barrier prevents drugs from reaching brain cells and shields treatment. creation nanocarriers to improve drug delivery internalization effectiveness may be solution this issue. In paper, we report on a new nanocarrier that was developed deliver anticancer doxorubicin cells. obtained by nanoemulsion polymerization diallyl disulfide with 1-allylthymine. Diallyl redox-sensitive molecule involved in redox cell activities,...
Novel mono- and dicationic pyrimidinic surfactants are synthesized their aggregation behavior is studied by methods of tensiometry nuclear magnetic resonance (NMR) self-diffusion. To estimate potentiality as gene delivery agents, the complexation with oligonucleotides (ONus) explored dynamic light scattering (DLS) zeta-potential titration ethidium bromide exclusion experiments. Bola-type amphiphile (BPM) demonstrates rather a weak affinity to ONus. Although it induces mixed associations...
Abstract Novel 6‐methyluracil derivatives with ω‐(substituted benzylethylamino)alkyl chains at the nitrogen atoms of pyrimidine ring were designed and synthesized. The numbers methylene groups in alkyl varied along electron‐withdrawing substituents on benzyl rings. compounds are mixed‐type reversible inhibitors cholinesterases, some them show remarkable selectivity for human acetylcholinesterase (hAChE), inhibitory potency nanomolar range, more than 10 000‐fold higher that...
Abstract Organophosphorus (OP) compounds represent a serious health hazard worldwide. The dominant mechanism of their action results from covalent inhibition acetylcholinesterase (AChE). Standard therapy acute OP poisoning is partially effective. However, prophylactic administration reversible or pseudo-irreversible AChE inhibitors before exposure increases the efficiency standard therapy. purpose study was to test duration protective effect slow-binding inhibitor (C547) in mouse model...
This paper presents the practical experience of creating a system professional self-determination in secondary school, based on pedagogical ideas K.D. Ushinsky. An approach to formulation principles students grades 8-10 according Ushinsky context implementation Federal Educational Standard basic general education is described. The necessity transition school conditions system-activity actualized. goals and objectives early orientation schoolchildren effective means involving them knowledge...
A series of bisuracils, in which uracil and 3,6-dimethyluracil moieties were bridged with a polymethylene spacer, the moiety contained pentamethylene radical ionic non-ionic aminobenzyl groups, synthesised. These bisuracils have been identified as cholinesterase inhibitors exceptional selectivity for acetylcholinesterase (AChE) over butyrylcholinesterase (BuChE). highly effective AChE inhibitors, demonstrated activity at nano- sub-nanomolar concentrations, BuChE. In kinetic studies lead 2b...
Abstract This study introduces innovative redox‐sensitive polymeric nanocarriers designed to deliver the photosensitizer meso ‐tetra( N ‐methyl‐4‐pyridyl)porphine and enhance anticancer photodynamic therapy. These release from a hydrophobic core in response elevated glutathione levels, enabling generation of reactive oxygen species upon irradiation. The glutathione‐sensitive is constructed using disulfide‐linked molecules, while hydrophilic shell, consisting 6‐methyluracil derivative,...
A series of 5'-phosphorylated (dialkyl phosphates, diaryl phosphoramidates, H-phosphonates, phosphates) 1,2,3-triazolyl nucleoside analogues in which the 1,2,3-triazole-4-yl-β-D-ribofuranose fragment is attached via a methylene group or butylene chain to N-1 atom heterocycle moiety (uracil quinazoline-2,4-dione) was synthesized. All compounds were evaluated for antiviral activity against influenza virus A/PR/8/34/(H1N1). Antiviral assays revealed three compounds, 13b, 14b, and 17a, showed...
New amphiphilic pyrimidinic macrocycles (APMs) with two (APM-1) and three (APM-2) decyl tails have been synthesized by quaternization of the bridged N. Complex examination APM-based systems help tensiometry, conductometry, dynamic light scattering, UV NMR spectroscopy provides evidence for their aggregation. Calculations based on surface tension isotherms packing parameter considerations make it possible to assume a lamellar when aggregating. Marked differences in aggregation behavior APM-1...