A5026725606- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Advanced Breast Cancer Therapies
- Lung Cancer Treatments and Mutations
- Head and Neck Cancer Studies
- HER2/EGFR in Cancer Research
- Gastric Cancer Management and Outcomes
- Breast Cancer Treatment Studies
- Intraperitoneal and Appendiceal Malignancies
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Metastasis and carcinoma case studies
- Multiple and Secondary Primary Cancers
- Prostate Cancer Treatment and Research
- Lung Cancer Diagnosis and Treatment
- Oral health in cancer treatment
- Colorectal and Anal Carcinomas
- Radiopharmaceutical Chemistry and Applications
- Gastrointestinal Tumor Research and Treatment
- Melanoma and MAPK Pathways
- CAR-T cell therapy research
- Cancer Genomics and Diagnostics
P.A. Hertzen Moscow Oncology Research Institute
2016-2025
Ministry of Health of the Russian Federation
2016-2025
Medical Radiological Research Center
2022-2025
Ministry of Health
2019-2023
Ministry of Health
2021
Research Medical Center
2021
Background: Peritoneal metastasis (PM) develop in more than 50 % of gastric cancer (GC) patients. Median survival without treatment is not 3-7 months, and 8-12 months after modern combination chemotherapy. Innovative therapeutic approaches are urgently needed. Methods: Phase-2, open label prospective clinical trial assessing safety efficacy bidirectional chemotherapy for treating peritoneal (PMGC). Treatment protocol included initial staging laparoscopy or laparotomy, 3-4 courses systemic...
Breast cancer currently occupies the first place in structure of morbidity female population worldwide. Approximately 15–20% breast patients have overexpression and/or amplification human epidermal growth factor receptor type 2 (HER2), which causes aggressive biological behavior tumor and is associated with poor prognosis. Anti-HER2 therapies significantly improved prognosis HER2-positive cancer. Starting from earliest stages (T2 N+), should be treated neoadjuvant drug therapy, allows direct...
The aim of the study was to search for data on effectiveness neoadjuvant therapy hormone-positive HER2-negative breast cancer. Material and methods. literature conducted in PubMed RISC databases. Publications from 2012 2024 were found. keywords used were: “breast cancer”, “bneoadjuvant chemotherapy”, “bsurgery”, “bluminal tumors”, “bhormone-dependent “bbreast-conserving surgery”. Results. indications chemotherapy patients with cancer are discussed, considering possibility achieving clinical...
В статье представлены результаты голосования I Cанкт-Петербургского международного консенсуса по диагностике и лечению рака молочной железы «Белые ночи 2024», посвященного наиболее актуальным спорным вопросам диагностики, хирургической тактики, лучевой терапии системного лечения данной категории пациентов. Под председательством член-корреспондента РАН, профессора Владимира Федоровича Семиглазова в международном консенсусе приняли участие 38 экспертов области диагностики (РМЖ),...
Aim. To study the role of progesterone receptor expression, tumor grade and Ki-67 level as possible predictors pathological complete response (pCR) to neoadjuvant chemotherapy in patients with stage IIA–IIB (cT1–2N1, cT2–3N0M0) breast cancer hormone-positive HER2-negative subtype. Materials methods . We retrospectively analysed efficacy (4AC+12P/4T) 100 stages subtype treated at P.A. Hertsen Moscow Oncology Research Institute from 2013 2022. The depending on tumour (G) proliferation index...
Despite advances in the early diagnosis of breast cancer (BC), identification locally advanced forms continues to be relevant. This is a complex category patients whose treatment includes use various methods with significant medical and economic costs, long-term rehabilitation. A particular difficulty cases progression forms. Patients BC require multidisciplinary approach. In absence an effect after neoadjuvant drug impossibility performing surgical intervention, are treated induction...
Objective. To determine clinical and morphological predictors influencing the achievement of pCR in patients with breast cancer (BC) after neoadjuvant therapy (NAT), to evaluate oncological outcomes group without NAT. Material methods. A single-center retrospective non-randomized study was conducted, for which 984 stage I–II treated at P.A. Herzen Moscow Oncology Research Institute from 2014 2022 were examined, whom surgical included subcutaneous/skin-sparing mastectomies simultaneous...
Treatment of patients with squamous cell oropharyngeal carcinoma is an urgent problem modern oncology. At the end last century, key role HPV infection in development cancer was proved, and significant differences survival rates were demonstrated depending on status tumor. Undoubtedly, papers presenting a comparative analysis clinical course two biological substypes same disease are demand. A rethinking treatment now required due to continued use single approach, despite reflected creation...
The Russian consensus on prevention, diagnostic and treatment of gastric cancer was prepared the initiative Moscow clinical scientific center named after A. S. Loginov Delphi method. Its aim to clarify consolidate opinions specialists most relevant issues diagnosis cancer. An interdisciplinary approach provided by participation leading gastroenterologists, oncologists surgeons.
Objective. To evaluate clinical and pathological responses to neoadjuvant polychemotherapy (NACT) in patients with stage IIA-IIB breast cancer of hormone-positive HER2-negative subtype depending on the level tumor cell proliferation index (Ki-67), analyze volume surgical intervention. Material methods. We analyzed results treatment 100 who received NACT according 4AC+12P/4T regimen at first complex followed by Department Oncology Reconstructive Plastic Surgery Breast Skin P.A. Herzen Moscow...
Diet plays a crucial role in cancer development and progression, beyond traditional risk factors. This review aims to summarize current evidence on the of diet specific nutrients focusing molecular mechanisms. We also discuss potential personalized dietary interventions, based tumor patient characteristics, enhancing prevention treatment strategies. The covers impact calories, protein, sugar, other components signaling pathways growth factors involved carcinogenesis. examine influence...
Differentiated thyroid cancer
Introduction. mBRAF mCRC has the aggressive phenotype. The incidence of such mutation in Europe and USA is around 8–14%, Asian countries – 4–8%. purpose this population-based study was to determine identifying prognostic factors pts with Russia. Materials methods. A multicenter retrospective analysis clinical data treatment results performed. main method for determining mutations a PCR. efficacy endpoint progression free survival (PFS) at 1 st line. Multivariate performed using Cox...
Расширение арсенала лекарственных препаратов для лечения метастатического рака молочной железы (мРМЖ) определяет необходимость оптимизации существующих подходов к выстраиванию наиболее эффективной линейности терапии. С появлением в клинической практике новых коньюгатов моноклональных антител, нацеленных на определенный рецептор, совмещенных с цитостатиком, поставило этот вопрос отношении терапии пациентов тройным негативным (ТН) и HER2-low РМЖ. В статье представлен обзор основных...
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Colorectal cancer (CRC) is one of the most common and lethal types cancer. Although researchers have made significant efforts to study mechanisms underlying CRC drug resistance, our knowledge this disease still limited, novel therapies are in high demand. It urgent find new targeted therapy considering limited chemotherapy options. KRAS mutations frequent molecular alterations CRC. However, there no approved K-Ras for these tumors yet. GSK-3β demonstrated be a critically important kinase...
Prostate cancer (RPP) is a malignant neoplasm that arises from the epithelium of prostate gland (PJ). рак предстательной железы; клинические рекомендацииThethiology and pathogenesis this disease remain poorly studied. Many studies are aimed at studying diet, food, hormonal impact, as well infections in etiology RLPG. The prevalence RPL depends on ethnic geographical features. highest incidence African Americans living United States (60% higher than white Americans), least high - Chinese...
Gastric cancer remains one of the most common malignancies in Russia. Despite steady decrease gastric incidence it still reaches 24.65 per 100 000 population (crude rate) 2019 with about 36 new cases annually. More than 29 people die every year. High mortality rate is mostly caused by an extremely significant proportion patients metastatic disease which reached 40.1% 2019. The majority related to Helicobacter pylori infection, salty diet, tobacco exposure as well hereditary syndromes....
Solid pseudopapillary neoplasm (SPN) of the pancreas is an extremely rare tumor, associated with favorable prognosis and long-term survival in patients advanced disease. However, limited data exist on systemic therapy for such patients. Herein, we present a case young woman history SPN, who progressed after multiple surgical resections chemotherapy regimens. The immunohistochemistry (IHC) showed overexpression estrogen receptors (ER) progesterone (PR) tumor tissue. patient started to receive...
Introduction. About 600 new cases of malignant neoplasms the paranasal sinuses and nasal cavity are detected annually in Russia. To date, there no randomized trials to determine optimal treatment algorithm for this group patients. Data on use induction chemotherapy squamous cell carcinoma sino-nasal tract limited a small series clinical observations and, often, retrospective nature. Aim. Evaluation effectiveness patients with locally advanced cavity. Materials methods. Since 2012, 22 cancer...