A5066492491- Head and Neck Cancer Studies
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Multiple and Secondary Primary Cancers
- Radiopharmaceutical Chemistry and Applications
- Advanced Breast Cancer Therapies
- Cleft Lip and Palate Research
- Cancer-related gene regulation
- Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- Salivary Gland Tumors Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Management of metastatic bone disease
- Renal cell carcinoma treatment
- Sinusitis and nasal conditions
- CAR-T cell therapy research
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Bone health and treatments
- Genetic factors in colorectal cancer
- Breast Cancer Treatment Studies
City Clinical Hospital
2024-2025
City Hospital
2024-2025
Moscow City Oncology Hospital №62
2023-2024
Ministry of Health of the Russian Federation
2022-2023
P.A. Hertzen Moscow Oncology Research Institute
2021-2023
Ministry of Health
2019-2023
Cancer of the biliary tract is rare and one most aggressive malignancies. The main method radical treatment surgical. However, only 1/3 patients can use this approach, while rest have an unresectable, locally widespread or already metastatic process. therapeutic tactic group systemic drug antitumor therapy. In article, we present a description clinical case effective patient with advanced intrahepatic cholangiocarcinoma using not standard cytostatics, but also modern targeted drugs.
Treatment of patients with squamous cell oropharyngeal carcinoma is an urgent problem modern oncology. At the end last century, key role HPV infection in development cancer was proved, and significant differences survival rates were demonstrated depending on status tumor. Undoubtedly, papers presenting a comparative analysis clinical course two biological substypes same disease are demand. A rethinking treatment now required due to continued use single approach, despite reflected creation...
Introduction. About 600 new cases of malignant neoplasms the paranasal sinuses and nasal cavity are detected annually in Russia. To date, there no randomized trials to determine optimal treatment algorithm for this group patients. Data on use induction chemotherapy squamous cell carcinoma sino-nasal tract limited a small series clinical observations and, often, retrospective nature. Aim. Evaluation effectiveness patients with locally advanced cavity. Materials methods. Since 2012, 22 cancer...
<h3></h3> Плоскоклеточный рак орофарингеальной области, ассоциированный с папилломавирусной инфекцией, является актуальной проблемой современной онкологии. Несмотря на визуальную локализацию, данная нозологическая форма отличается высокой степенью запущенности (только у 16,1% пациентов данное заболевание выявляется начальных стадиях (I—II), что приводит к неудовлетворительным отдаленным результатам лечения и обусловливает необходимость агрессивных подходов терапии. В обзоре представлены...
e18052 Background: According to Globocan in 2020 were identified 98 412 new cases of oropharyngeal squamous cell carcinoma the world. It was proved that human papillomavirus (HPV) is a favorable prognostic factor. Patients with HPV-positive oropharynx cancer have higher indicators progression-free survival (PFS) and overall (OS). As induction chemotherapy, only TPF regimen (cisplatin/ docetaxel/ 5-fluorouracil) has been approved which high toxic profile. Published results randomized trials...
Gastric cancer is an important medical and social problem all over the world. The aggressiveness of course this disease reflected by high figures one-year mortality, which due to both neglect at time diagnosis unsatisfactory results surgical treatment even a localized tumor process, from biological point view casts doubt on possibility performing “radical” operation for type malignant tumor. Currently, “gold standard” has become conduct perioperative chemotherapy according FLOT scheme...
Melanoma of the skin is one most aggressive cancers. Until recently, metastatic melanoma was associated with an extremely negative prognosis: median overall survival for this category patients no more than 7–8 months. Thanks to improvement therapeutic approaches, it possible achieve a significant increase in life expectancy unresectable and process. Currently, several targeted immunotherapy options are available treatment or melanoma. These approaches have thoroughly taken leading place...
OBJECTIVE To optimize orthopedic care in patients with complicated course of metastatic lesions the long bones. MATERIAL AND METHODS There were 201 (72 men and 129 women) who underwent for bones period from 2006 to 2019. Breast cancer metastases diagnosed 71 (35%) cases, kidney - 56 (28%) patients, prostate 19 (9%) without a primary identified focus 15 (8%) patients. Other forms observed 40 (20%) All divided into two groups. The first group included 136 (68%) segmental resections bone...
Given the favorable prognosis associated with HPV-positive oropharyngeal cancer, cancer care professionals are actively discussing feasibility of de-escalating treatment strategy for this cohort patients. The purpose study was to improve outcomes in patients locally advanced HPV- positive squamous cell carcinoma by identifying optimal induction chemotherapy (ICH) regimen, particular, using a two-drug ICH. Material and Methods . included 27 (T3–4N0–1, or T1–4N2–3) P16-positive carcinoma. All...
Purpose. Evaluation of the effect smoking on immediate effectiveness (achievement objective response – OR) induction chemotherapy in patients receiving combined treatment for locally advanced HPV-positive squamous cell carcinoma oropharynx. Patients and methods . Sixty-eight (51 men 17 women) with cancer oropharynx associated papillomavirus were included study, which was carried out from 2021 to 2023 at P. Hertsen Moscow Oncology Research Institute Branch National Medical Radiological Centre,...
<h3>ЦЕЛЬ ИССЛЕДОВАНИЯ</h3> Улучшить результаты лечения пациентов с местно-распространенным ВПЧ-позитивным плоскоклеточным раком ротоглотки путем оптимизации режима индукционной химиотерапии, в частности, использования двухкомпонентной схемы. <h3>МАТЕРИАЛ И МЕТОДЫ</h3> С 2021 г. исследование включено 13 ротоглотки. Всем больным на первом этапе комбинированного проводилось 3 курса химиотерапии (ИХТ) по схеме ТР (доцетаксел 75 мг/м2 + цисплатин мг/м2, цикл 21 день). Далее всем пациентам было...
e15561 Background: Regorafenib is considered the standard third-line therapy of mCRC. However, modest efficacy and significant toxicity regorafenib urges search for new therapeutic approaches. In various countries, re-challenge previously effective treatment regimens being considered. We compared effectiveness variants systemic in third subsequent lines treatment. Methods: analyzed prospective database pts with mCRC from two clinics Russian Federation. The statistical hypothesis implied...
Breast cancer is the most common female and cause of death from in women worldwide. Overexpression HER2 / neu, which an unfavorable predictor associated with a more aggressive course disease, detected every 5th breast patient. Over past 20 years, targeted therapy has changed natural cancer. However, standard neoadjuvant chemotherapy regimens combination are poorly tolerated and, therefore, considered suboptimal. Evidently, not all patients require such toxic treatment regimens. In this...
Presently primary-multiple malignancies are still poorly studied and represent a complex problem in clinical Oncology. The frequency of occurrence metachronous or synchronous tumors remains at high level. It is worth noting that about 1.5% patients with primary multiple had malignant neoplasm the prostate. Performing simultaneous laparoscopic operations allow to achieve rapid postoperative rehabilitation patient, avoid risk re-operation anesthesia, addition, there clear economic benefit, no...
This article discusses current approaches to first-line chemotherapy for non-resectable head and neck squamous cell carcinoma describes factors affecting the choice of treatment regimen according results randomized clinical trials. We provide a rationale creating long-term strategy in different situations. also report two cases concomitant administration cetuximab platinum-based therapy as an example high efficacy monoclonal antibodies.