A5023521385- BRCA gene mutations in cancer
- Breast Cancer Treatment Studies
- DNA Repair Mechanisms
- Advanced Breast Cancer Therapies
- Reconstructive Surgery and Microvascular Techniques
- Nutrition, Genetics, and Disease
- Medical and Biological Sciences
- CRISPR and Genetic Engineering
- Cancer Genomics and Diagnostics
- Breast Lesions and Carcinomas
- Breast Implant and Reconstruction
- Cancer Treatment and Pharmacology
- Salivary Gland Tumors Diagnosis and Treatment
- Estrogen and related hormone effects
- Body Image and Dysmorphia Studies
- Anesthesia and Pain Management
- Medical History and Innovations
- Carcinogens and Genotoxicity Assessment
- Head and Neck Cancer Studies
- Stoma care and complications
- HER2/EGFR in Cancer Research
- Childhood Cancer Survivors' Quality of Life
- Advances in Oncology and Radiotherapy
- Acute Lymphoblastic Leukemia research
- PARP inhibition in cancer therapy
State Budget Institution of Health St. Petersburg Clinical Research Center Specialized Types of Medical Care
2017-2024
Saint Petersburg State Pediatric Medical University
2017-2024
Ministry of Health of the Russian Federation
2017-2024
Russian Academy of Sciences
2018
Molecular Oncology (United States)
2018
Institute of Oncology NN Petrov
2004-2018
First Pavlov State Medical University of St. Petersburg
2018
Candid
2017
Abstract The BLM gene belongs to the RecQ helicase family and has been implicated in maintenance of genomic stability. Its homozygous germline inactivation causes Bloom syndrome, a severe genetic disorder characterized by growth retardation, impaired fertility highly elevated cancer risk. We hypothesized that is candidate for breast (BC) predisposition. Sequencing its entire coding region 95 genetically enriched Russian BC patients identified two heterozygous carriers c.1642 C > T (Q548X)...
The gene for Nijmegen chromosomal breakage syndrome (NBS1) plays a role in variety of processes protecting stability. Recently, it was suggested Polish case-control study that the founder hypomorphic mutation NBS1, 657del5, which occurs approximately 0.5% Slavic subjects, may be associated with an increased risk breast cancer (BC). We attempted to validate these findings Russian who are also descent. Heterozygous carriers 657del5 were detected 2 173 (1.16%) bilateral cases, 5 700 (0.71%)...
В статье представлены результаты голосования I Cанкт-Петербургского международного консенсуса по диагностике и лечению рака молочной железы «Белые ночи 2024», посвященного наиболее актуальным спорным вопросам диагностики, хирургической тактики, лучевой терапии системного лечения данной категории пациентов. Под председательством член-корреспондента РАН, профессора Владимира Федоровича Семиглазова в международном консенсусе приняли участие 38 экспертов области диагностики (РМЖ),...
Hereditary breast-ovarian cancer syndrome contributes to as much 5-7% of breast (BC) and 10-15% ovarian (OC) incidence. Mutations in the "canonical" genesBRCA1andBRCA2occur 20-30% affected pedigrees. In addition toBRCA1andBRCA2 mutations, germ-line lesions theCHEK2,NBS1, andPALB2genes also contribute familial BC clustering. The epidemiology hereditary Russia has some specific features. impact "founder" effect is surprisingly remarkable: a single mutation,BRCA15382insC, accounts for vast...
Т. 18, №3 -НОВЫЕ ПОХОДЫ В ХИРУРГИИ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ Е.М.Бит-сава 1
Although the probability of both parents being affected by BRCA1 mutations is not negligible, such families have been systematically described in literature. Here we present a large breast-ovarian cancer family, where 3 sisters and 1 half-sister inherited maternal 5382insC mutation while remaining 2 carried paternal 1629delC allele. No homozygous has detected, that consistent with data on lethality knockout mice. This report exemplifies identification single cancer-predisposing within index...
Background . In recent years, the availability of reconstructive plastic surgery has reached a new level. when performing an oncological operation, question arises about choosing further reconstruction tactics: through one-stage or delayed reconstruction. vast majority cases, tissue expanders/implants are used for simultaneous breast reconstruction, but it is still unclear which allograft allows achieving best aesthetic results operation without increasing incidence postoperative...
Т. 18, №4 - ПРАВИЛА ЗАБОРА МАТЕРИАЛА ДЛЯ МОРФОЛОГИЧЕСКОГО ИССЛЕДОВАНИЯ (АСПИРАЦИОННАЯ БИОПСИЯ, ЭКСЦИЗИОННАЯ И ИНЦИЗИОННАЯ ТРЕПАН-БИОПСИЯ, ЗАБОР АСЦИТИЧЕСКОЙ ПЛЕВРАЛЬНОЙ ЖИДКОСТИ, КОСТНОГО
Key words: breast cancer; neoadjuvant drug therapy; organ-preserving operations; oncoplastic resection margins.
Т. 19, №2 - БИОПСИЯ СИГНАЛЬНЫХ ЛИМФАТИЧЕСКИХ УЗЛОВ ПРИ РАКЕ МОЛОЧНОЙ ЖЕЛЕЗЫ1 Клинический научно-практический центр специализированных видов медицинской помощи (онкологический
Performing immediate reconstructive plastic surgery, regardless of the type reconstruction, reduces level anxiety in its various manifestations, disorders, depression, improves quality life and increases aesthetic satisfaction patient with results surgical treatment.
Oncological surgery, history.
e12664 Background: The purpose of the breast cancer (BC) preoperative therapy (PT) is to achieve a complete pathological response (pCR) that correlates with overall survival or decrease in its size for organ-preservation surgery. hormonal therapy, dose-dense standard chemotherapy patients (pts) hormone-positive (HR+ BC) allow pCR only 6% cases. biological features luminal A tumor and lack an ideal predictive markers terms are research basis additional treatment options. One them use MT, i.e....