A5071648290- Breast Cancer Treatment Studies
- Breast Implant and Reconstruction
- Reconstructive Surgery and Microvascular Techniques
- Breast Lesions and Carcinomas
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Cancer Diagnosis and Treatment
- Body Contouring and Surgery
- Reconstructive Facial Surgery Techniques
- Cancer survivorship and care
- Male Breast Health Studies
- Cancer and Skin Lesions
- Cancer Risks and Factors
- Cancer Cells and Metastasis
- Metastasis and carcinoma case studies
- Body Image and Dysmorphia Studies
- Radiomics and Machine Learning in Medical Imaging
- BRCA gene mutations in cancer
- Nonmelanoma Skin Cancer Studies
- Radiopharmaceutical Chemistry and Applications
- Dermatologic Treatments and Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Angiogenesis and VEGF in Cancer
- Multiple and Secondary Primary Cancers
Ministry of Health of the Russian Federation
2015-2025
P.A. Hertzen Moscow Oncology Research Institute
2015-2025
Peoples' Friendship University of Russia
2017-2025
Sechenov University
2017-2025
Medical Radiological Research Center
2015-2025
Ministry of Health
2023
Botkin Hospital
2015
Background. Currently, after subcutaneous/skin-preserving mastectomies with simultaneous reconstruction in cancer of stages I–II, the need for radiation therapy is debatable, especially presence favorable subtypes or when complete clinical regression achieved neoadjuvant polychemotherapy. Materials and methods. A retrospective non-randomized study was conducted, which included 1135 breast patients who received treatment at P.A. Herzen Moscow State Medical Institute from 2014 to 2023, all...
Применение биопсии «сторожевого» лимфатического узла (БСЛУ) при раке молочной железы (РМЖ) представляет собой минимально травматичную манипуляцию, которая является золотым стандартом диагностики регионарного лимфоколлектора и альтернативой аксиллярной лимфодиссекции, что позволяет избежать, в первую очередь, таких осложнений как контрактура плечевого сустава, лимфедема руки. Данный обзор литературы направлен на анализ результатов БСЛУ у пациентов с первоначально cN+ статусом РМЖ, которых...
Disease stage and especially condition of the sentinel lymph node (SLN) assessed in patients with breast cancer prior to treatment are among most important prognostic factors. SLN is first regional system receiving outflow from primary tumor. biopsy blue dye gradually replaced traditional axillary dissection as standard early cancer. In recent years, technique contrast-enhanced sonography microbubble contrast agents for examination has been studied both animal human trials. Aim review...
Breast cancer (BC) is the most common malignant tumor in women. In patients who have undergone antitumor treatment at an early stage of BC, death long term more often occurs from cardiovascular diseases (CVD) than cancer. Numerous studies indicate that risk cardiomyopathy and/or heart failure, coronary artery disease among BC survivors received anthracyclines trastuzumab increased. Currently, detection cardiotoxicity using cardiac imaging and circulating biomarkers widely evaluated clinical...
Despite advances in the early diagnosis of breast cancer (BC), identification locally advanced forms continues to be relevant. This is a complex category patients whose treatment includes use various methods with significant medical and economic costs, long-term rehabilitation. A particular difficulty cases progression forms. Patients BC require multidisciplinary approach. In absence an effect after neoadjuvant drug impossibility performing surgical intervention, are treated induction...
Objective. To determine clinical and morphological predictors influencing the achievement of pCR in patients with breast cancer (BC) after neoadjuvant therapy (NAT), to evaluate oncological outcomes group without NAT. Material methods. A single-center retrospective non-randomized study was conducted, for which 984 stage I–II treated at P.A. Herzen Moscow Oncology Research Institute from 2014 2022 were examined, whom surgical included subcutaneous/skin-sparing mastectomies simultaneous...
Введение. Капсулярная контрактура (КК) – наиболее частое и клинически значимое осложнение как в эстетической, так реконструктивной хирургии рака молочной железы, большинстве случаев требующее повторного хирургического вмешательства. В настоящее время проводятся исследования, целью которых является определение показаний к профилактике консервативному лечению капсулярных контрактур. Материалы методы. Включено исследование 25 пациенток с капсулярной контрактурой II-III степенью по Baker после...
Background. Breast reconstruction with allo- and/or autologous materials is becoming the most popular surgical treatment option for breast cancer patients. The aim of study. To evaluate efficacy reconstructions in patients depending on technique reintervention. Materials and methods. object study was a group 70 female who underwent repeat using endoprosthesis, flap autografting, and/o r combination these methods, between 2016 2023. age ranged from 25 to 68 years. mean 46.8 ± 8.6 Body mass...
The aim of the study was to search for data on effectiveness neoadjuvant therapy hormone-positive HER2-negative breast cancer. Material and methods. literature conducted in PubMed RISC databases. Publications from 2012 2024 were found. keywords used were: “breast cancer”, “bneoadjuvant chemotherapy”, “bsurgery”, “bluminal tumors”, “bhormone-dependent “bbreast-conserving surgery”. Results. indications chemotherapy patients with cancer are discussed, considering possibility achieving clinical...
В статье представлены результаты голосования I Cанкт-Петербургского международного консенсуса по диагностике и лечению рака молочной железы «Белые ночи 2024», посвященного наиболее актуальным спорным вопросам диагностики, хирургической тактики, лучевой терапии системного лечения данной категории пациентов. Под председательством член-корреспондента РАН, профессора Владимира Федоровича Семиглазова в международном консенсусе приняли участие 38 экспертов области диагностики (РМЖ),...
Aim. To study the role of progesterone receptor expression, tumor grade and Ki-67 level as possible predictors pathological complete response (pCR) to neoadjuvant chemotherapy in patients with stage IIA–IIB (cT1–2N1, cT2–3N0M0) breast cancer hormone-positive HER2-negative subtype. Materials methods . We retrospectively analysed efficacy (4AC+12P/4T) 100 stages subtype treated at P.A. Hertsen Moscow Oncology Research Institute from 2013 2022. The depending on tumour (G) proliferation index...
Foreign body in the breast of an iatrogenic nature is extremely rare observation diagnosed after surgical treatment formations, while often simulating a benign or malignant neoplasm. For final diagnosis, with histological examination removed drug used. The presented article interesting because during biopsy nodular formation mammary gland, presence foreign was suspected, taking into account anamnesis data, it known that 5 years ago patient underwent sectoral resection both breasts for...
Purpose of the study . To evaluate results targeted lymphadenectomy (TLAE) in patients with breast cancer (BC) cT1–3N1M0 after neoadjuvant systemic therapy (NAST). Patients and methods The represents a prospective analysis 83 diagnosed stage T1–3N1M0 who were treated Department Reconstructive Plastic Surgery skin at P. Hertsen Moscow Oncology Research Institute (Moscow, Russian Federation). divided into two groups: main group 1 (n = 45), TLAE was performed using metal tag (clip) surgery;...
Purpose: To study the effectiveness of magnetic resonance imaging mammary glands in detecting multicentric lesions breast cancer. Matreial and Methods : From 2022 to 2023, a prospective was conducted, including 57 cancer patients, who underwent for purpose clarifying diagnosis process, followed by surgical treatment Department Oncology reconstructive Plastic Surgery skin P.A. Herzen Moscow State Medical Institute. In postoperative period, data results pathomorphological examination material...
Objective. To evaluate clinical and pathological responses to neoadjuvant polychemotherapy (NACT) in patients with stage IIA-IIB breast cancer of hormone-positive HER2-negative subtype depending on the level tumor cell proliferation index (Ki-67), analyze volume surgical intervention. Material methods. We analyzed results treatment 100 who received NACT according 4AC+12P/4T regimen at first complex followed by Department Oncology Reconstructive Plastic Surgery Breast Skin P.A. Herzen Moscow...
The surgical stage remains the main one in combined and complex treatment of breast cancer, radical mastectomy is still option for vast majority Russians hospitals. absence both a physical psychological trauma woman leads to profound deformation personality, significantly worsening quality life. Thus, reconstructive plastic surgery became an integral part modern clinical oncology. Radiation therapy can lead development complications after reconstruction, vice versa, reconstructed mammary...
Summary: Capsular contracture is one of the most common complications after breast reconstruction. Surgical treatment main option for capsular correction and includes capsulotomy, capsulectomy, removal/replacement affected implant. However, surgical trauma from reoperation, along with reduced quality life, in patients clinically significant has prompted a search alternative options. The use botulinum toxin type A neurological diseases keloid scars aesthetic practice nudged idea using same...
Breast reconstruction after complex oncological treatment is an urgent issue due to the high incidence of breast cancer.
 Aim. To analyze effect postoperative radiotherapy on fat necrosis in single-stage autologous with a DIEP flap and evaluate number complications groups without radiotherapy, as well determine risk factors for complications.
 Materials methods. The medical records 34 cancer patients who underwent one-stage using skin-sparing/subcutaneous mastectomy subsequent...
To analyze the efficacy of sentinel lymph node detection using indocyanine green (ICG) in breast cancer.The study included 153 cancer patients (stage 0-I-II-III, cN0 or cN1-ycN0) between October 2022 and April 2023. All underwent biopsy ICG.Sentinel was successfully detected 150 cases out ICG injections. Optimal period injection its accumulation regional nodes 10-12 min. Sensitivity 98.0% that exceeds approximate value radioisotope method adopted as a standard (96.9-97.2%), well sensitivity...
Background . Simultaneous breast reconstruction after subcutaneous or skin-sparing mastectomy using silicone implants is associated with a high risk of postoperative complications. Therefore, the issue additional shell cover for highly relevant. Synthetic and biological are believed to be most effective. Aim To assess efficacy safety autologous dura mater grafts in reconstructive surgeries cancer patients. Materials methods This study included 164 patients who had undergone simultaneous...
During the last years has been a worldwide trend towards rejuvenating breast cancer, and evolution of reconstructive surgery is proceeding at rapid pace. The surgical method primary in combined complex treatment radical mastectomy still main option for most Russian clinics. Most women who need prefer one-stage reconstruction, because woman quickly rehabilitated psychologically physically after this operation. Nevertheless, use silicone endoprostheses did not solve problems reconstruction...
Introduction . Indications for radiation therapy after mastectomies with/without reconstruction at T12N01M0 remain unclear; treatment standards contain references to the possible administration of factors that increase breast cancer recurrence. Materials and methods. A retrospective singlecenter, nonrandomized study enrolled 984 patients treated P.A. Gertsen Moscow Cancer Research Institute from 2014 2022. Patients were divided into 2 groups: a radiotherapy group nonradiotherapy group....