A5073085140- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Breast Lesions and Carcinomas
- Estrogen and related hormone effects
- Cancer Cells and Metastasis
- Metabolomics and Mass Spectrometry Studies
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- Multiple and Secondary Primary Cancers
- Cancer-related molecular mechanisms research
- Cancer Diagnosis and Treatment
- Diabetic Foot Ulcer Assessment and Management
- Circular RNAs in diseases
- Advanced Proteomics Techniques and Applications
- Appendicitis Diagnosis and Management
- MicroRNA in disease regulation
- Cancer Risks and Factors
- MRI in cancer diagnosis
- Cancer and Skin Lesions
- Lung Cancer Treatments and Mutations
- BRCA gene mutations in cancer
- Mass Spectrometry Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Intraperitoneal and Appendiceal Malignancies
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation
2018-2025
Ulyanovsk State University
2011-2022
Ulyanovsk Regional Oncology Center
2012-2016
Scientific Research Institute of Experimental and Clinical Medicine
2015
Ministry of Health of the Russian Federation
2015
Russian Cancer Research Center NN Blokhin
2011
Krasnoyarsk State Medical University
2005
Metastasis is a serious and often life-threatening condition, representing the leading cause of death among women with breast cancer (BC). Although current clinical classification BC well-established, addition minimally invasive laboratory tests based on peripheral blood biomarkers that reflect pathological changes in body utmost importance. In study, serum proteome lipidome profiles for 50 patients (25) without metastasis were studied. Targeted proteomic analysis concertation measurements...
В статье представлены результаты голосования I Cанкт-Петербургского международного консенсуса по диагностике и лечению рака молочной железы «Белые ночи 2024», посвященного наиболее актуальным спорным вопросам диагностики, хирургической тактики, лучевой терапии системного лечения данной категории пациентов. Под председательством член-корреспондента РАН, профессора Владимира Федоровича Семиглазова в международном консенсусе приняли участие 38 экспертов области диагностики (РМЖ),...
Background. Determining androgen receptor (AR) expression in triple-negative breast cancer (TNBC) is a promising tool oncology. Aim. To identify the correlation of AR with clinical and genetic characteristics tumor disease prognosis. Materials methods. The study included 246 subjects TNBC treated at Ulyanovsk Regional Oncological Clinical Dispensary Kulakov National Medical Research Center for Obstetrics, Gynecology, Perinatology (Moscow) from 2014 to 2024. was determined by...
Introduction . Triple-negative breast cancer (TNBC) is a group of malignant tumors with poor prognosis and varying molecular genetic characteristics. In TNBC, genes determine whether patients belong to clusters that differ in prognosis. There are not enough studies consider as risk factors for progression. The aim this study was identify TNBC which associated high progression, evaluate their prognostic significance. Material methods This included 246 TNBC. Forty-five performing various...
The DNA methylation profile of breast cancer differs from that in healthy tissues and can be used as a diagnostic prognostic biomarker. Aim this study: To compare the levels gene small malignant tumors (<2 cm), tissue, fibroadenoma, to evaluate effectiveness modified Methylation Sensitive-High Resolution Melting (MS-HRM) method for analysis. Analysis was performed using MS-HRM method. For validation, five genes were confirmed by pyrosequencing. main study group included 96 samples control 24...
In the modern world breastfeeding (BF) is considered as a significant factor in reducing risk of developing malignant tumors mammary gland and ovaries. However, problem maintenance or refusing BF neoplasms (malignant neoplasms) still remains open. recent years, there has been steady increase breast cancer (BC), especially developed countries, with more than 10% all malignancies (BC) diagnosed women under 40 years age. The presented article highlights aspects maintaining lactation different...
Current methods for the intraoperative determination of breast cancer margins commonly suffer from insufficient accuracy, specificity and/or low speed analysis, increasing time and cost operation as well risk recurrence. The purpose this study is to develop a method rapid accurate using direct molecular profiling by mass spectrometry (MS). Direct fingerprinting tiny pieces tissue (approximately 1 × mm) performed home-built spray ionization source installed on Maxis Impact quadrupole...
Real-time molecular navigation of tissue surgeries is an important goal at present. Combination electrosurgical units and mass spectrometry (MS) to perform accurate visualization biological tissues has been pursued by many research groups. Determination composition a particular location surgical smoke analysis now increasing interest for clinical use. However, commonly lacking specificity associated with significant carbonization chemical contamination, which are mainly related the high...
The purpose of this work is to determine the intratumoral distribution miRNA expression profiles in luminal breast cancer (BC). study included 33 certain BC cases A or B (Her2-) subtypes. relative levels miRNA-20a; -21; -125b; -126; -200b; -181a; -205; -221; -222; -451a; -99a; -145; -200a; -214; -30a; -191; and small nuclear RNAs U6, U54, U58 were measured by RT-qPCR four intratumor areas each specimens surrounding normal mammary gland tissues. Comparative analysis between tissue different...
The involvement of axillary lymph nodes is one the most important prognostic factors, significantly affecting treatment strategy for early breast cancer (BC). risk node metastases depends directly on a number factors (age women, size tumor, presence lymphovascular invasion and biological characteristics cancer). evaluation regional status in patients with BC includes clinical examination zones ultrasound study (US), using these methods can help to shape, borders, margins structure....
Goal: To analyze the tumor response to NACT in patients with aggressive biological subtypes of stage II–III breast cancer based on contemporary scoring systems for residual pathological evaluation and burden according RCB system. Materials methods: A total 172 women (triple negative 34,3 %; HER2‑positive tumors 28,5 luminal B Her2‑negative BC 37,2 %) were included this analysis. The median age was 47 years (24–81 years); сT2 predominant size (65,1 %); 69,8 % had regional lymph node...
Research of cancer progression mechanisms and their impact on metabolism tumor cells microenvironment is an important element in drug development for target therapy. In this study, changes tissue margin lipid profiles, were associated with the following clinical morphological characteristics: size, stage, multifocalite, grade, number lymph node metastasis, Nottingham prognostic index, total malignancy score, level Ki67 protein. Lipid profiling was performed by reverse-phase chromato-mass...
Ductal carcinoma in situ (DCIS) is an extremely heterogeneous disease terms of clinical manifestations, morphological changes, and expression biomarkers, which determine the risk subsequent development invasive breast cancer (BC). Diagnosis treatment DCIS prevents tumors (which reduces potential death from BC); however, prognostic value local depends on biological characteristics its. The tumor grade, presence comedonecrosis estrogen receptors are key factors for tactics prognosis. symptoms...
Background. Triple-negative breast cancer is a group of tumors with different clinical and morphological features, prognosis, response to therapy. There are from 4 6 molecular genetic varieties this type malignant neoplasm. Aim. Identification individual clusters triple-negative that differed in terms overall disease-free survival. Material methods. On the basis Regional Clinical Oncological Dispensary (Ulyanovsk) National Medical Research Center for Obstetrics, Gynecology Perinatology named...
This article provides a review of studies analyzing the etiology, diagnosis, and treatment Peitz–Jeghers syndrome, as well risk cancer different locations in patients with this genetic disorder. We report case syndrome associated breast young women two generations (mother daughter). Despite specific clinical manifestations (multiple hamartomatous polyps developing childhood ink-black mucous pigmentation woman her immediate relatives), was diagnosed only after development consultation...
Background . The role of neoadjuvant chemotherapy (NACT) in luminal HER2-negative breast cancer (BC) remains highly controversial due to the lack reliable predictors drug therapy efficacy. Objective : evaluate effectiveness NACT patients with aggressive BC and compare modern systems for assessing pathomorphological response. Materials methods tumor response regimens was assessed 64 stage II–III. median age women 46.5 years (range 31–76 years), 76.6 % had primary operable stages (cT1–3N0–1),...
To study the features of protein expression gene
Breast angiosarcoma (BAS) is an extremely rare and poorly studied neoplasm, the etiology of primary BAS remains controversial, secondary most often radio-induced. Radio-induced breast tumors usually appear 10–20 years after initial treatment; however, for this period much shorter about 4–7 years. This review presents literature data on features clinic, diagnosis treatment BAS, as well own clinical case observation radio-induced sarcoma left breast, that developed 4 cancer treatment.