A5089898358- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Occupational and environmental lung diseases
- Neuroblastoma Research and Treatments
- Cancer therapeutics and mechanisms
- Gastric Cancer Management and Outcomes
- Endometrial and Cervical Cancer Treatments
- Advanced Breast Cancer Therapies
- Cancer Immunotherapy and Biomarkers
- Effects of Radiation Exposure
- Immunotherapy and Immune Responses
- Pleural and Pulmonary Diseases
- Immune Cell Function and Interaction
- Cervical Cancer and HPV Research
- Advances in Oncology and Radiotherapy
- Neurofibromatosis and Schwannoma Cases
- Colorectal Cancer Treatments and Studies
- Blood transfusion and management
- Lung Cancer Treatments and Mutations
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal Tumor Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Cancer Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Erythropoietin and Anemia Treatment
Ministry of Health of the Russian Federation
2018-2020
Russian Cancer Research Center NN Blokhin
2013-2019
National Medical Research Center of Cardiology
2019
В статье представлены результаты голосования I Cанкт-Петербургского международного консенсуса по диагностике и лечению рака молочной железы «Белые ночи 2024», посвященного наиболее актуальным спорным вопросам диагностики, хирургической тактики, лучевой терапии системного лечения данной категории пациентов. Под председательством член-корреспондента РАН, профессора Владимира Федоровича Семиглазова в международном консенсусе приняли участие 38 экспертов области диагностики (РМЖ),...
Background: Several studies show that the combination chemotherapy with ramucirumab allows to improve treatment results of advanced gastric cancer (GC). Irinotecan fluoropyrimidines is own second line options for these patients. As angiogenesis inhibitors can enhance efficacy chemotherapy, we investigated irinotecan and in metastatic GC. Methods: Eligible patients had morphologically verified GC disease progression during or within 4 months following first-line therapy. They received FOLFIRI...
The article reviews the experience of chemotherapy department N.N.Blokhin Russian Cancer Recearch Center RAMS from 1996 to 2012 in treatment SCLC patients with combinations cytotoxic drugs cisplatin and carboplatin. efficiency different schemes on basis platinum etoposide, irinotecan, docetaxel, ACNU (EP, IP, DP, AVP)has been studied. data mode treatment, side effects, survival after these schemes. Maximum was shown by EP, AVP
Anemia has a noticeable negative impact on the quality of life cancer patients and determines prognosis disease. The need to treat anemia is determined by its expectancy, since hypoxia caused can be associated with resistance chemotherapy, radiation therapy, causes stimulation genetic mutations neoangiogenesis in tumor, which makes it difficult control it. methods correction are clinical picture antitumor treatment being carried out. use blood transfusions limited involves number risks....
Malignant pleural mesothelioma is associated with poor prognosis and resistance to chemotherapy. This gives reason search for as well new effective methods of treatment predictive factors. Programmed cell death receptor PD-1 its ligands PD-L1 PD-L2 are the representatives system «immunologic checkpoint» whose main function regulation modulation immune response, decrease damage in organs tissues also prevention running an autoimmune process. Tumor cells able use a PD-1/PD-L1-signaling pathway...
Considering the fact that group of neuroendocrine carcinomas (NECs) grade 3 is heterogenous, in year 2017 a new subgroup welldifferentiated tumors (NETs G3) was described. NETs G3 are with more favorable prognosis and less sensitive to platinum-based chemotherapy regimens than NECs, they also have peculiar morphogenetical qualities: lower ki‑67 index (mean 35.0 %), higher somatostatin receptors expression, absence DAXX/ATRX/MEN 1 genes mutation, p53 expression TP53 mutation. Nowadays...
Currently, the effectiveness of treatment is assessed by Response Evaluation Criteria In Solid Tumors (RECIST) criteria. The stabilization disease one results treatment. This term means a slight growth or regression tumor without appearance new lesions, when it impossible to assign these changes neither progression nor partial regression, but in any case evaluated as ineffective But often leads improvement quality life, slowdown and metastasis thereby win terms life expectancy. purpose...
Tumor-infiltrating lymphocytes (TILs) play a key role in the formation of anti-tumor immunity and, as studies have shown, can be one markers treatment effectiveness and cancer prognosis. The aim was to study subpopulation composition lymphoid infiltrate early luminal breast patients receiving neoadjuvant chemotherapy (NACT) its effect on achieving pathological complete response (pCR). Materials methods . We included 24 who received anthracycline-taxane-contain-ing preoperative chemotherapy....
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Cytostatic therapy still remains the gold standard for treatment of inoperable pleural mesothelioma with a life expectancy about 9–18 months. The article presents results use immune checkpoint inhibitors in first line malignant and management immune-related adverse events an elderly patient.
Modern approach to individualization of the patients’ treatment, based on careful supervision over minimum manifestations an illness and competent combination chemotherapy, target agents, radiotherapy allow supervise a disease for long time.
Patients with advanced small cell lung cancer (SCLC) have an extremely poor prognosis against a background of standard therapy combination etoposide platinum drugs. In randomized, double-blind the CA184-156 phase 3, efficacy and safety ipilimumab or placebo in preparations was evaluated as first line treatment for disseminated SCLC. Material methods. Randomization patients carried out ratio 1:1 group therapy: + drug (carboplatin cisplatin) preparation placebo. Ipilimumab/placebo administered...
Introduction. Patients with advanced small cell lung cancer (SCLC) have an extremely poor prognosis on the background of standard chemotherapy combination etoposide and platinum-based drugs. In a randomized, double-blind СА184-156 phase III study, efficacy safety ipilimumab (immune checkpoint inhibitor) or placebo in platinum drugs were evaluated as first-line therapy disseminated SCLC. The article deals results treatment patients SCLC, who participated international multicenter study...
Gastric cancer (GC) is one of the most common types malignant tumour worldwide and ranked fifth in incidence pattern third mortality pattern. In Russian Federation, 39.9% patients are diagnosed with stage IV gastric cancer, 46.6% die within first year after diagnosis. The combinations trastuzumab platinum derivatives fluoropyrimidines (trastuzumab + doublet) regarded as standard therapy against HER2 positive disseminated cancer. We studied efficacy toxicity combination three-component...
Anaplastic lymphoma kinase (ALK) translocation is a rare genetic disorder that underlies lung cancer development. As rule, these are young people, people with no or little smoking experience in whom the diagnosis made at late stage of disease, when there distant metastases; liver and brain often affected. The right choice treatment policy patients ALK-positive non-small cell can significantly improve survival rates. And molecularly targeted therapy ALK inhibitors effective even cases....
Background. The diagnostics of neuroendocrine tumors (NET) is complex due to many factors such as the heterogeneity themselves, different localization tumor process, and presence severe hormonal syndromes. A special place in diagnostic search given study biochemical markers which are conditionally divided into universal specific ones. Materials methods. Chromogranin (CGA) a marker that most cases identifies nature characterized by best combination sensitivity specificity. Pancreatic...
Advanced well differentiated neuroendocrine tumors (NET) have poor sensitivity to chemotherapy. Approaches the second and subsequent lines of treatment not been developed date Aranosa is a derivative nitrosourea. it close streptozotocin in terms its chemical structure, but has more favorable toxicity profile. Aranoza actively studied NET. The drug was effective fourth line patient with NET liver metastases.