A5033926803- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Breast Lesions and Carcinomas
- BRCA gene mutations in cancer
- Cancer Cells and Metastasis
- Male Breast Health Studies
- HER2/EGFR in Cancer Research
- Renal cell carcinoma treatment
- MicroRNA in disease regulation
- Surgical site infection prevention
- Cancer-related molecular mechanisms research
- Reconstructive Surgery and Microvascular Techniques
- Medical and Biological Sciences
- Cancer and Skin Lesions
- Cancer Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Advanced Breast Cancer Therapies
- Metastasis and carcinoma case studies
- Nutrition, Genetics, and Disease
- Cancer Treatment and Pharmacology
- Multiple and Secondary Primary Cancers
- Immune Cell Function and Interaction
- Genetic factors in colorectal cancer
- Kruppel-like factors research
Ministry of Health of the Russian Federation
2018-2023
Russian Cancer Research Center NN Blokhin
2017-2019
Introduction. There is ample evidence that disseminated tumor cells (DTC), which are found in the bone marrow (BM) of patients with breast cancer (BC), including early stages, progenitors subsequent distant metastasis. Therefore, BM-DTC represent an additional tool for understanding carcinogenesis and estimating prognosis. Nevertheless, existing data controversial. The purpose study – to determine frequency DTC detection BM luminal BC also its relationship some clinical immunophenotypic...
Surgical treatment of breast cancer (BC) has undergone significant changes over the past half century. Oncoplastic operations are a relatively new variant organ-preserving surgical cancer. Its idea is to combine principles oncology and plastic surgery in order obtain oncological safe cosmetic acceptable results. Despite widespread implementation these operations, high-quality studies on benefits oncoplastic comparison with other methods not enough. Actual issues was considered this...
The prognosis of breast cancer in the elderly is associated with increased risk various complications. Recommendations for treatment this group patients are controversial and range from radical surgery to conservative therapy. There no specific clinical recommendations age group. It makes problem relevant.
Introduction. Neoadjuvant chemotherapy (NACT) is the standard of care for II–III stages TN BC. Complete pathomorphological response (pCR) associated with a signifiant increase in event-free and overall survival. In addition, absence pCR, post-neoadjuvant adjuvant therapy prescribed, while if pCR achieved, additional treatment not carried out. Despite large number studies on NACT BC, different regimens various clinical trials make it diffiult to interpret their results. Objective. To...
Recent studies have shown that triple-negative breast cancer (TN BC) is characterized by the highest mutational load and immunogenicity compared to other subtypes, as well degree of tumor-infiltrating lymphocytes (TILs) infiltration, which play an important role in development antitumor immunity treatment response. A significant disadvantage standard immunohistochemical method for determining TILs inability fully assess subpopulation structure immune including minor populations. Aim : The...
The methylation of CpG islands in the promoter regions miRNA genes is an epigenetic modification that plays a decisive role breast cancer (BC) initiation and progression. aim study was to investigate frequency 5 (miRNA-9–1, miRNA-9–3, miRNA-34b/c, miRNA-193A, miRNA-129-2) mammary epithelial neoplasms. Methylation-specific polymerase chain reaction (MS-PCR) used detect methylated genes. 62 patients took part this study. It found all miRNAs significantly higher tumor tissue than adjacent...
Currently, mammography is the main screening method for diagnosing breast cancer (BC); but process of carcinogenesis begins long before appearance a visualized tumor. For successful early diagnosis cancer, systematic approach required, that includes all stages tumor development. On example BC we consider possibilities integrating recent scientific achievements oncogenetics and proteomics with standard methods. In this article investigate using genetic research, serum markers radiation...
Tumor-infiltrating lymphocytes (TILs) play a key role in the formation of anti-tumor immunity and, as studies have shown, can be one markers treatment effectiveness and cancer prognosis. The aim was to study subpopulation composition lymphoid infiltrate early luminal breast patients receiving neoadjuvant chemotherapy (NACT) its effect on achieving pathological complete response (pCR). Materials methods . We included 24 who received anthracycline-taxane-contain-ing preoperative chemotherapy....
Particular emphasis has been recently placed on the mechanisms of carcinogenesis in breast cancer (BC), including those male BC. The paper describes major risk factors for BC patients and covers role BRCA1 BRCA2 gene mutations occurrence this pathology. most important studies conducted area their results are presented.
Introduction: Surgical site infections (SSI) are one of the key problems in surgical practice. Despite achievements modern medicine, ongoing preventive measures, incidence wound infection remains quite high. This is especially relevant for oncoplastic surgery, since most cases installation foreign materials (expanders, implants, meshes) required to achieve a satisfactory cosmetic result. The purpose study: identify common cause infectious complications after reconstructive operations on...
Introduction. The efficacy of dose-dense AC in adjuvant chemotherapy luminal breast cancer (ER+ BC) compared with the standard dosing regimen followed by switching to taxanes has been proven numerous clinical trials and a large meta-analysis EBCTCG group. However, no study about efficiency this neoadjuvant setting published. aim study. To assess effectiveness regimens (NAC) ER + HER2-BC (4 once every 2 weeks (dose dense, ddAC), then 4 courses Docetaxel 3 or 12 weekly injections Paclitaxel...