A5016839657- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Angiogenesis and VEGF in Cancer
- Cancer Treatment and Pharmacology
- Cancer Risks and Factors
- Estrogen and related hormone effects
- Cancer and Skin Lesions
- Metastasis and carcinoma case studies
- HER2/EGFR in Cancer Research
- Cancer, Hypoxia, and Metabolism
- Phytoestrogen effects and research
- Lymphatic System and Diseases
- Pancreatic and Hepatic Oncology Research
- Breast Implant and Reconstruction
- Reconstructive Surgery and Microvascular Techniques
- Cancer, Lipids, and Metabolism
- Advanced Breast Cancer Therapies
- Surgical site infection prevention
- Circadian rhythm and melatonin
- Radiopharmaceutical Chemistry and Applications
- Biomarkers in Disease Mechanisms
- Protein Degradation and Inhibitors
- Cancer-related Molecular Pathways
- Menopause: Health Impacts and Treatments
Ministry of Health of the Russian Federation
2019-2024
Sechenov University
2014-2024
Academy of Medical Sciences
2008-2014
Russian Academy of Sciences
2008-2014
Cancer Research Center
2014
The review presents current data on the major pathogenetic mechanisms underlying uncontrolled growth and dissemination of tumor its resistance to conventional treatment. Cell genetic instability associated with accumulation mutations in genes controlling cell differentiation is a key factor proliferation. Due understanding detailed analysis carcinogenesis processes provide basis for creation new anticancer drugs which turn enables optimization individualization cancer
According to various studies, local recurrence (LR) of breast cancer (BC) occurs in 3-20%. The standard surgical care is the removal a recurrent tumor, but issue extent surgery on regional lymph nodes case relapses has not been resolved. In 2022 and 2023 at our institution we identified 27 patients with cancer. As primary lumpectomy axillary node dissection (ALND) was performed 13 (48.1%), sentinel biopsy (SNB) - 5 (18.5%), radical mastectomy 2 (7.4%), skin-sparing SNB – 3 (11.1%). LR...
The current standard of care for patients with early-stage (T2-3N0) breast cancer (EBC) is neoadjuvant chemotherapy (NAC) followed by conserving surgery and sentinel lymph node biopsy (SLNB). After SLNB about 7% observe upper limb or lymphedema. SOUND trial demonstrated the safe refusal in postmenopausal women T1N0 luminal [1]. We would like to conduct a study on avoiding HER-2-positive T2-3N0 complete expressed clinical response after NACT. identified HER2-positive treated NAC at our...
Introduction. Today, resection margins are assessed in different ways, but clinical practice, preference is given to the histological method with macro- and microscopic examination of margins. Assessment can be carried out not only during planned examination, also intraoperative examination. Aim. To evaluate feasibility assessment when performing organ-preserving operations patients primary resectable breast cancer. Materials methods. A retrospective study analyzed data from early cancer who...
Diseases of the mammary glands (usually benign) have incidence 5–12% in structure children diseases. Breast cancer is extremely rare (less than 1% all breast diseases). This review contains actual data on most common focal pathology teenage girls such as: hyperplasia, cysts and fibroepithelial tumors. Clinical manifestations, morphological picture diagnostics are described. Main approaches to treatment patients with defined. The presented crucial for timely diagnosis glands, selection...
The research provided includes analysis of the current state problem on use oral contraceptives and menopausal hormone therapy. These therapeutic options were evaluated in terms their importance for risk breast cancer. possibility using these drugs a cohort high-risk patients (women with family history cancer) group benign pathology was analyzed as well. Modern trends therapy prescription different clinical situations determined.
The article presents updated data concerning the molecular mechanisms of influence well-known in clinical practice drug Mastodynon. paper provides evidence a significant effect compounds containing its composition on cell lines number malignant neoplasms: breast cancer, hepatocellular carcinoma, leukemia and others. obtained are extremely attractive perspective using as preventive agent.
Breast cancer (BC) ranks first in incidence among women. For successful treatment of BC, depending on the molecular type and stage disease, chemotherapy is used, side effects which are manifested by menopausal symptoms, sexual dysfunction, depressive states. However, not all patients after BC receive appropriate therapy for what significantly worsens their quality life. One symptoms that brings most severe discomfort vasomotor symptom, a form temperature dysfunction with peripheral...
Introduction: Surgical site infections (SSI) are one of the key problems in surgical practice. Despite achievements modern medicine, ongoing preventive measures, incidence wound infection remains quite high. This is especially relevant for oncoplastic surgery, since most cases installation foreign materials (expanders, implants, meshes) required to achieve a satisfactory cosmetic result. The purpose study: identify common cause infectious complications after reconstructive operations on...
The article deals with a peculiar group of breast diseases, which belongs to the B3 category according BI-RADS classification, so-called lesions undefined malignant potential. basic information concerning their biological behavior and modern tactical approaches management patients similar changes in mammary gland are presented. possibility conservative management, as well minimization surgical aid, cases indications for it, up vacuum aspiration biopsy is being considered. In addition,...