Introduction. There is ample evidence that disseminated tumor cells (DTC), which are found in the bone marrow (BM) of patients with breast cancer (BC), including early stages, progenitors subsequent distant metastasis. Therefore, BM-DTC represent an additional tool for understanding carcinogenesis and estimating prognosis. Nevertheless, existing data controversial. The purpose study – to determine frequency DTC detection BM luminal BC also its relationship some clinical immunophenotypic...

Despite recent advances in targeted and immune therapy, 5‑year overall survival stages III–IV of melanoma is 50 10–20 %, respectively. Modern biomarkers, which are used clinical practice, not sufficiently effective for early diagnosis prognosis assessment. In the last decade, circulating microRNAs (miRNAs) have come to be regarded as “ideal” biomarkers. This article presents characteristics miRNA biogenesis, well provides a critical review miRNAs promising diagnostic prognostic

Introduction. Immunotherapy for breast cancer is not a universal tool and requires careful selection of patients its implementation. When using immune checkpoint inhibitors PD-1/PD-L1, determining the IHC status tumor sometimes insufficient results expression these proteins in cells are contradictory. In last decade, research interest has increased soluble forms which can be identified serum or plasma patients, while concentrations differ with various malignancies change during progression,...

Introduction. B1-lymphocytes are a subpopulation of B-cells, the proportion which in spleen accounts for 5 % total number B-cells. predominantly secrete IgM, plays an important role induction tumor cell apoptosis. Splenec tomy purpose adequate lymph node dissection gastric cancer causes marked and prolonged immunological disorders. It primarily affects B1a-lymphocyte subpopulation, provides thymus-independent immune response. Objective. To study features B-cell component immunity patients...

We have studied bone marrow lymphocytes subpopulations in 67 patients with breast cancer and 13 benign processes the mammary gland. Morphological study of cellular composition immunological analysis lymphocyte been done. Comparative characterization diseases was done by flow cytometry. The gate Mature (CD45++) T cells (CD3), b (CD19), NK (CD56+CD3–). Among (CD3+) TCRγδ TCRαβ cells, a subpopulation CD4, CD8, CD4+, CD25+ T-regulatory cells. Within В-lymphocytes (CD19+) CD10, CD38, CD5...

In the literature there has been increased interest in study of androgenetic receptors (AR) different molecular subtypes breast cancer (BC) but we haven’t found consensus about role levels androgens and their metabolites samples biological fluids for development cancer. Determination level tumor patients with is very relevant promising direction prognosis disease search new complementary approaches to endocrine therapy cancer, especially when basal-like subtype.

Despite the fact that melanoma is a tumor of visual localization, mortality from skin remains one leading causes worldwide. Early metastasis melanoma, even during initial stages process, indicates high malignant potential tumor. Moreover, metastatic resistant to current chemotherapy regimens, which significant problem today. Progression, resistance drug therapy associated with population stem cells, are characterized by dysregulation signaling pathways and aberrant phenotypes. The formation...

Objective. Determine the frequency of occurrence tyrosine kinase expression mutated ALK and TAG-72 gene among patients with primary melanoma skin, to identify their association a number histological parameters, assess diagnostic value determination TAG-72. Materials methods. Paraffin blocks surgical material from 40 skin melanoma. For routine examination, was fixed 10 % neutral formalin for 24 h, poured into paraffin, sections were prepared thickness 4–5 μm, stained hematoxylin eosin. IHC...

This article discusses the mechanisms of influence microRNAs on carcinogenesis in breast cancer (breast cancer), their potential role as markers for early detection, prognosis and effectiveness treatment. Epigenetic regulation miсroRNA expression indirect effect pathogenesis disease are described.

The prognosis of breast cancer in the elderly is associated with increased risk various complications. Recommendations for treatment this group patients are controversial and range from radical surgery to conservative therapy. There no specific clinical recommendations age group. It makes problem relevant.

Purpose : To study possible errors in the interpretation and analysis of PET/CT studies with 18 F-FES performed patients estrogen receptor-positive breast tumors. Material methods: Data from 140 PET were retrospectively analyzed 2017 to 2023. The included histologically confirmed cancer, before start specific treat­ment, as well when progression is detected or if a metastatic process suspected at initial examination stage. Results: Recommendations are given for assessment various changes...

Introduction. Numerous studies using multivariate analysis have confirmed the relationship between low hemoglobin and / or hypoxia of tumor tissue with a worsening prognosis. The study objective was to assess state iron metabolism in breast cancer patients perioperative period, before conducting adjuvant chemotherapy for adequate administration recombinant erythropoietins preparations. Materials methods. object included 17 relatively favorable prognosis, luminal types A B (Her 2 neu positive...

Estrogen receptors are one of the major targets in cancer cells, acting on which it is possible not only to control processes carcinogenesis, but also inhibit tumor cells growth. Brilliant confirmation this results long-term application first targeted therapy - antiestrogen tamoxifen breast patients with positive hormonal status tumor. Being discovered 90s, estrogen receptor beta enhanced understanding estrogen-mediated signaling pathway and receptor-related interactions. This review...

Introduction. In recent years, a separate publications have appeared indicating that interleukin 6 (IL-6) and the protein hepcidin 25 (GP25) play significant role for development of functional iron deficiency (FID) in oncological patients with widespread tumor process. It is important to differentiate between FID anemia (IDA), since they same morphological characteristics, but their treatment fundamentally different. The aim this study was main metabolites ferrokinetics, IL-6 C-reactive...

Early and adequate correction of the anemic syndrome (AS) cancer patients can prevent deterioration in quality life be considered as a reserve for increasing effectiveness treatment breast (BC). The aim study was to assess status iron using modern methods ferrokinetics on background adjuvant chemotherapy early diagnosis AS. object included 21 with relatively favorable prognosis, luminal types A B (Her 2 / neu positive or negative), three times negative type. examination carried out...

The organization of work and evaluation the effectiveness primary specialized accreditation in «MultiProfile simulation centers» National Medical Research Center oncology named after N.N. Blokhin were discussed this paper.

Study of tumor-infiltrating lymphocyte subpopulations was performed in 19 patients with breast cancer (core biopsy material). Two probes were used multiparameter flow cytometry: CD4/CD25/CD3/CD45 and CD8/CD56/CD3/CD45. Mean percentage different cell types within lymphocytes (CD45++ SSCLow) as follows: CD3 – 88.2%, CD4 45.1%, CD8 40.4%, NK (CD3–CD56+) 1.6%, CD4+CD25+ 4.1 %. Ratio CD8/CD4 less than 1 53 % cases. In cases prominent moderate CD45 infiltration CD8+ significantly higher low...

The article presents an overview of the literature about breast sarcomas (nonepithelial malignances). Primary are extremely rare, with less than 1 % all malignant tumors breast. Breast carcinomas cause increased interest scientists due to their unique clinical and pathological features unpredictable prognosis.