A5031173308- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Metastasis and carcinoma case studies
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- Immunotherapy and Immune Responses
Ministry of Health of the Russian Federation
2020-2022
This article discusses the mechanisms of influence microRNAs on carcinogenesis in breast cancer (breast cancer), their potential role as markers for early detection, prognosis and effectiveness treatment. Epigenetic regulation miсroRNA expression indirect effect pathogenesis disease are described.
Introduction. Among the immunological prognostic factors in breast cancer, intratumoral lymphocytes play an important role. Pronounced infiltration of tumor by CD8 is associated with a favorable prognosis. The expression transferrin receptor (CD71) on cells, contrary, unfavorable bone marrow cancer patients has been studied very little terms role hematopoietic cells and lymphocyte subpopulations. study objective was to investigate B-lymphocyte subpopulations evaluate their value. Materials...
Backgrоund . Breast cancer molecular subtypes serve as a basis for combined treatment of the disease. Some them (e. g. triple negative subtype) are prognostically unfavorable. Recently, we’ve demonstrated role bone marrow B-cells in breast prognosis. Correlation between these parameters (molecular and lymphocyte subpopulations) have not yet studied. Aim To investigate prognostic to see relationships subpopulational composition lymphocytes. Materials methods Detailed study has been performed...