A5008330780- Erythropoietin and Anemia Treatment
- Iron Metabolism and Disorders
- Biomarkers in Disease Mechanisms
- Cancer Immunotherapy and Biomarkers
- Neutropenia and Cancer Infections
- Pomegranate: compositions and health benefits
- Phagocytosis and Immune Regulation
- GDF15 and Related Biomarkers
- Agriculture and Biological Studies
- Medicinal plant effects and applications
- Tryptophan and brain disorders
- Enzyme function and inhibition
- Platelet Disorders and Treatments
- Healthcare Systems and Public Health
- Paraoxonase enzyme and polymorphisms
- Venous Thromboembolism Diagnosis and Management
- Blood properties and coagulation
- Glutathione Transferases and Polymorphisms
- Erythrocyte Function and Pathophysiology
- Acute Myeloid Leukemia Research
- Kruppel-like factors research
- Infection Control and Ventilation
- COVID-19 epidemiological studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- SARS-CoV-2 and COVID-19 Research
Ministry of Health of the Russian Federation
2019-2023
Ministry of Health
2021
Russian Cancer Research Center NN Blokhin
2001-2019
Особенности клеточного иммунитета медицинских работников в первую волну пандемии SARS
A study of the clinical analysis blood and major metabolites ferrokinetics in 107 breast cancer patients before treatment was conducted. In 31 (28.9%) revealed anemic syndrome (AS). feature AS is pronounced microcytosis, erythrocyte hypochromia low hemoglobin content reticulocytes. Most often (n = 22; 71%) there iron deficiency (IDA), which characterized by a concentration (F), ferritin (FR), hepcidin 25 (GP25), interleukin-6 (IL-6) high - soluble transferrin receptors (rTFR), (TRF). 9 (29%)...
A study of interleukin-6 (IL-6), hepcidin-25 (GP-25) was conducted in 22 patients with breast cancer before neoadjuvant chemotherapy and 27 healthy women the control group. Significant expression GP-25 protein revealed patients, compared to control. The rates were high both anemic sindrome (AS) without it (p <0.01). Latent iron deficiency, AS, IDA functional deficiency (FJ) more often detected stage III disease. significant difference parameters IL-6 noted, indicators higher No close...
Introduction. Numerous studies using multivariate analysis have confirmed the relationship between low hemoglobin and / or hypoxia of tumor tissue with a worsening prognosis. The study objective was to assess state iron metabolism in breast cancer patients perioperative period, before conducting adjuvant chemotherapy for adequate administration recombinant erythropoietins preparations. Materials methods. object included 17 relatively favorable prognosis, luminal types A B (Her 2 neu positive...
Introduction. In recent years, a separate publications have appeared indicating that interleukin 6 (IL-6) and the protein hepcidin 25 (GP25) play significant role for development of functional iron deficiency (FID) in oncological patients with widespread tumor process. It is important to differentiate between FID anemia (IDA), since they same morphological characteristics, but their treatment fundamentally different. The aim this study was main metabolites ferrokinetics, IL-6 C-reactive...
The purpose of the review is to highlight current possibilities for prevention and treatment venous thrombotic complications in patients with cancer. data 52 scientific sources published Russian foreign press 1997–2020 are considered. Cancer at high risk complications, which worsen outcome anticancer one leading causes death. Thrombosis an oncological patient increases death by 30 times, associated fatal thromboembolism a more aggressive course disease. role pathogenesis played disorders...
Early and adequate correction of the anemic syndrome (AS) cancer patients can prevent deterioration in quality life be considered as a reserve for increasing effectiveness treatment breast (BC). The aim study was to assess status iron using modern methods ferrokinetics on background adjuvant chemotherapy early diagnosis AS. object included 21 with relatively favorable prognosis, luminal types A B (Her 2 / neu positive or negative), three times negative type. examination carried out...
Background . Colorectal cancer is the most commonly diagnosed among all malignant neoplasms. This disease accompanied by development of anemic syndrome (AS). complication not only worsens results treatment and, as a result, reduces overall survival, but also quality life patients, adherence to treatment. Aim To study expression hepcidin 25 (HP25), prohepcidin (PROHP), ferritin (FR), interleukin 6 (IL-6) and metabolites nitric oxide (NO x ) in peripheral blood patients colorectal cancer,...
Background. The pathways of iron acquisition, outflow, storage and regulation are disrupted in cancer, which suggests that the reprogramming metabolism is one central aspects survival tumor cells. Aim. Is to review generalize modern literature data on hepcidin, ferroportin prospects for correction cancer patients. Materials Methods. paper presents results international domestic studies peculiarities its search relevant sources was carried out web Science, PubMed, Medline, eLibrary.ru systems...
Evaluation of anemic syndrome (AS) was performed in 79 patients with advanced stages Hodgkin's lymphoma (LH) at various chemotherapy (CT) according to the EACOPP-14 scheme. Against background treatment, number erythrocytes and, accordingly, HCT indices decreased each subsequent cycle (CTC) and reached maximum reduction 5, 6 th CCT. Absolute iron deficiency (IDA), which combined a low level EPO an inadequate degree anemia, found few LH (5 people, 6.3%). Functional (FDZH) diagnosed 9 (11.4%),...
A study of the main indicators red blood (RBC, HGB, HCT, MCV, MCH) and concentration EPO, sTfR in 9 cancer patients with anemic syndrome (AS) against sepsis was carried out. Among them, chronic disease anemia (ACh), normocytic, normochromic characteristics cells low hematocrit predominated. In 2 patients, microcytosis erythrocyte hypochromia were noted, significantly higher than normal (0.9 ± 0.07 μg / ml), amounted to 2.7 ml one them 1.9 other, which testified t iron deficiency...
Immune thrombocytopenia is an immunosuppressed acquired disease characterized by low platelet levels in peripheral blood and increased risk of bleeding. This pathology deserves special attention cases patients who are scheduled for surgery, which undoubtedly requires careful preparation the patient surgery a complete laboratory analysis, including thromboelastogram. article describes clinical case successful surgical treatment with immune thrombocytopenia.
Introduction . Patients with cancer are more likely to develop thromboembolic complications, and the occurrence of thrombosis complicates course anticancer treatment worsens survival rate patients. Low molecular weight heparins (LMWH) is first choice for cancer-associated thrombosis, as there extensive evidence on efficacy safety LMWH in patients based current knowledge. Materials methods. There were 190 under our supervision at various stages complex treatment. Of these, 70 acute pulmonary...