A5099636906- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- Reconstructive Surgery and Microvascular Techniques
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Breast Lesions and Carcinomas
- Radiomics and Machine Learning in Medical Imaging
- Anatomy and Medical Technology
- Breast Implant and Reconstruction
P.A. Hertzen Moscow Oncology Research Institute
2024-2025
Ministry of Health of the Russian Federation
2024-2025
Medical Radiological Research Center
2025
The aim of the study was to search for data on effectiveness neoadjuvant therapy hormone-positive HER2-negative breast cancer. Material and methods. literature conducted in PubMed RISC databases. Publications from 2012 2024 were found. keywords used were: “breast cancer”, “bneoadjuvant chemotherapy”, “bsurgery”, “bluminal tumors”, “bhormone-dependent “bbreast-conserving surgery”. Results. indications chemotherapy patients with cancer are discussed, considering possibility achieving clinical...
Aim. To study the role of progesterone receptor expression, tumor grade and Ki-67 level as possible predictors pathological complete response (pCR) to neoadjuvant chemotherapy in patients with stage IIA–IIB (cT1–2N1, cT2–3N0M0) breast cancer hormone-positive HER2-negative subtype. Materials methods . We retrospectively analysed efficacy (4AC+12P/4T) 100 stages subtype treated at P.A. Hertsen Moscow Oncology Research Institute from 2013 2022. The depending on tumour (G) proliferation index...
Objective. To determine clinical and morphological predictors influencing the achievement of pCR in patients with breast cancer (BC) after neoadjuvant therapy (NAT), to evaluate oncological outcomes group without NAT. Material methods. A single-center retrospective non-randomized study was conducted, for which 984 stage I–II treated at P.A. Herzen Moscow Oncology Research Institute from 2014 2022 were examined, whom surgical included subcutaneous/skin-sparing mastectomies simultaneous...
Background. Breast reconstruction with allo- and/or autologous materials is becoming the most popular surgical treatment option for breast cancer patients. The aim of study. To evaluate efficacy reconstructions in patients depending on technique reintervention. Materials and methods. object study was a group 70 female who underwent repeat using endoprosthesis, flap autografting, and/o r combination these methods, between 2016 2023. age ranged from 25 to 68 years. mean 46.8 ± 8.6 Body mass...
Purpose: To study the effectiveness of magnetic resonance imaging mammary glands in detecting multicentric lesions breast cancer. Matreial and Methods : From 2022 to 2023, a prospective was conducted, including 57 cancer patients, who underwent for purpose clarifying diagnosis process, followed by surgical treatment Department Oncology reconstructive Plastic Surgery skin P.A. Herzen Moscow State Medical Institute. In postoperative period, data results pathomorphological examination material...
Objective. To evaluate clinical and pathological responses to neoadjuvant polychemotherapy (NACT) in patients with stage IIA-IIB breast cancer of hormone-positive HER2-negative subtype depending on the level tumor cell proliferation index (Ki-67), analyze volume surgical intervention. Material methods. We analyzed results treatment 100 who received NACT according 4AC+12P/4T regimen at first complex followed by Department Oncology Reconstructive Plastic Surgery Breast Skin P.A. Herzen Moscow...
There is a steady trend towards de-escalation of surgical intervention in the breast cancer treatment strategy. At first, this topic concerned de-velopment and implementation methods organ-preserving operations on mammary gland itself. With advent concept development sentinel lymph node biopsy technique, problem performing gentle lymphadenectomy with prevalence cN0 process was solved. In recent years, most innovative technique has begun to develop, namely targeted lymphadenectomy, which...