A5068425067- Aquaculture disease management and microbiota
- Fish biology, ecology, and behavior
- Cancer, Hypoxia, and Metabolism
- Adrenal and Paraganglionic Tumors
- Diet and metabolism studies
- Cancer-related molecular mechanisms research
- Hydrogen's biological and therapeutic effects
- Neurological Disorders and Treatments
- Molecular Biology Techniques and Applications
- Congenital Heart Disease Studies
- Breastfeeding Practices and Influences
- Neurological Disease Mechanisms and Treatments
- Genetic factors in colorectal cancer
- Pituitary Gland Disorders and Treatments
- Cardiovascular Issues in Pregnancy
- Infant Nutrition and Health
- Healthcare Systems and Public Health
- Glioma Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Congenital Anomalies and Fetal Surgery
- Chemical Reactions and Isotopes
- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- Neuroinflammation and Neurodegeneration Mechanisms
Engelhardt Institute of Molecular Biology
2021-2023
Ulyanovsk State University
2017-2019
Radical prostatectomy is the gold standard treatment for prostate cancer (PCa); however, it does not always completely cure PCa, and patients often experience a recurrence of disease. In addition, clinical pathological parameters used to assess prognosis choose further tactics treating patient are insufficiently informative need be supplemented with new markers. this study, we performed RNA-Seq PCa tissue samples, aimed at identifying potential prognostic markers level gene expression miRNAs...
To study the efficacy and safety of recognan (citicoline) in treatment cognitive depressive disorders chronic cerebrovascular pathology (chronic brain ischemia) developed patients with arterial hypertension and/or atherosclerosis.Seven hundred thirty-six pathology, impairment mild dementia were examined. The sample included 279 (37.9%) men 457 (62.1%) women aged from 35 to 80 years (mean age 64.5±8.7 years). drug ('Gerofarm', Russia) was administered dose 1000 mg daily during 30 days....
Aim: To review the main methods of intestinal microbiota studying. Key points. Currently, molecular genetic are used mainly for basic research and do not have a unified protocol data analysis, which makes it difficult to implement them in clinical practice. Measurement short chain fatty acids (SCFA) concentrations plasma provides data, can serve as an indirect biomarker colonic composition. However, currently available evidence is insufficient relate obtained values (SCFA levels ratio)...
Colorectal cancer (CRC) is one of the most common and lethal types cancer. Although researchers have made significant efforts to study mechanisms underlying CRC drug resistance, our knowledge this disease still limited, novel therapies are in high demand. It urgent find new targeted therapy considering limited chemotherapy options. KRAS mutations frequent molecular alterations CRC. However, there no approved K-Ras for these tumors yet. GSK-3β demonstrated be a critically important kinase...
Annual fish of the genus Nothobranchius are promising models for aging research. reproduces typical aspects vertebrate aging, including hallmarks brain aging. Meclofenoxate (MF) is a well-known compound that can enhance cognitive performance. The drug prescribed asthenic conditions, trauma, and vascular diseases brain. It believed MF able to delay age-dependent changes in human However, until now, there has been no study effect on transcriptome. In present work, we performed an RNA-Seq...
Nothobranchius is a genus of small annual killifish found in Africa. Due to the relatively short lifespan, as well easy breeding and care, fish are becoming widely used vertebrate model system. Studying genome transcriptome these essential for advancing field. In this study, we performed de novo assembly brain tissues from guentheri using Trinity. Annotation 104,271 potential genes (with transcripts longer than 500 bp) was carried out; 24,967 (53,654 transcripts), which at least one GO...
Malignant middle ear paraganglioma (MEPGL) is an exceedingly rare tumor of the neuroendocrine system. In general, MEPGLs represent as slow growing and hypervascularized benign neoplasms. The genetic basis MEPGL tumorigenesis has been poorly investigated. We report a case malignant accompanied by comprehensive analysis primary metastasis. Based on whole-exome sequencing data, germline pathogenic mutation p.R230H in SDHB gene, encoding for subunit B mitochondrial complex II, was found patient....
Vascular endothelial growth factor is a consequence of angiogenesis links, while at the same time it exhibits different activity under changes in breast milk storage conditions. Purpose . To study vascular (vascular factor, VEGF) and peripheral blood women with states health dynamics lactation, to assess effect physical exposure on this indicator. Material methods. 96 lactating were enrolled study. The sampling for laboratory part was carried out 3–5 days after birth, then 1, 3, 6 months...