A5027002029- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Esophageal Cancer Research and Treatment
- Gastrointestinal Tumor Research and Treatment
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Esophageal and GI Pathology
- Multiple and Secondary Primary Cancers
- Helicobacter pylori-related gastroenterology studies
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Lung Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal disorders and treatments
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Tracheal and airway disorders
- Gallbladder and Bile Duct Disorders
- Lung Cancer Treatments and Mutations
- Gut microbiota and health
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
Ministry of Health of the Russian Federation
2018-2025
Russian Medical Academy of Continuous Professional Education
2019-2024
Hadassah Medical Center
2023
Ministry of Health
2020-2023
Russian Cancer Research Center NN Blokhin
2006-2019
Cancer Research Center
2015
665 Background: Neuroendocrine gastric tumors (gNETs) type 1 are associated with chronic autoimmune atrophic gastritis, hypergastrinemia and usually have multifocal lesions high frequency of recurrence (up to 70% for 2 years). Somatostatin analogs (SA) showed promising data in neoadjuvant setting 84% complete responses a small retrospective trial. The aim this study was evaluate the efficacy adjuvant treatment SA recurrent gNETs 1. Methods: This retrospective, single-center included patients...
In the immunotherapy based on immune checkpoint inhibition (IC), additional ICs are being studied to increase its effectiveness. An almost unstudied feature is possible co-expression of ICs, which can determine therapeutic efficacy their inhibition. For selection promising information association expression with cancer development may be essential. We have obtained data correlation ADAM17, PVR, TDO2, CD274, CD276, CEACAM1, IDO1, LGALS3, LGALS9, and HHLA2 genes in gastric (GC). All but one,...
EVs are involved in local and distant intercellular communication play a vital role cancer development. Since have been found almost all body fluids, there currently active attempts for their application liquid diagnostics. Blood is the most commonly used source of screening markers, although percentage tumor-derived blood extremely low. In contrast, GJ, as biofluid, expected to be enriched with GC-associated EVs. However, from GJ never applied underinvestigated overall. Here we show that...
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Colorectal cancer is the third most commonly diagnosed worldwide. Human gut microbiome plays important roles in protecting against it, as well contributing to its onset and progression. Identification of specific bacterial taxa associated with early stages colorectal may help develop effective microbiome-based diagnostics. For precancerous lesions, links their characteristics luminal tumor-associated composition are be elucidated. Paired stool tumor brush biopsy samples were collected from...
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Рекомендации по эндоскопической диагностике, лечению и наблюдению пациентов с эпителиальными новообразованиями толстой кишки 2022 год О
Introduction : The results of six randomized control trials have been published by 2022, which evaluated the efficacy adding PD-1 inhibitors to first-line chemotherapy in patients with metastatic esophageal cancer. However, it still remains unclear derive most clinical benefit from combined therapy. Therefore, is necessary evaluate combination anti-PD1 treatment different patient subgroups. Materials and methods We conducted a meta-analysis controlled stage IV cancer who received drugs...
The Russian consensus on prevention, diagnostic and treatment of gastric cancer was prepared the initiative Moscow clinical scientific center named after A. S. Loginov according to Delphi method. Its aim clarify consolidate opinions specialists most relevant issues diagnosis cancer. An interdisciplinary approach provided by participation leading gastroenterologists, oncologists surgeons.
4055 Background: Outcome of the patients (pts) with locally advanced esophageal cancer is poor. A prospective trial was undertaken to investigate whether preoperative chemotherapy (CT) followed by surgery results in increase disease free survival (DFS) pts resectable thoracic cancer. Methods: Previously untreated stage T 3–4 N 0–1 M 0 , 1–2 1 were eligible for study. After clinical evaluation (incl. chest CT-scan, endosonography) they randomized into CT (two cycles FLEP: cisplatin 80 mg/m 2...
Introduction: Esophageal cancer (EC) is a malignant disease with low survival rates and limited treatment options in the later stages. The epidemiological situation developed countries tends to improve. However, most states, including Russian Federation, remains critical condition. Epidemiology of EC: one aggressive disease. According International Agency for Research on Cancer (IARC), 2018, 572 thousand new cases RP were registered world (3.2 % total number disease). In 508.6 deaths from...
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The article briefly describes the mechanism of action immunotherapeutic drugs that suppress activity “checkpoints” immune response CTLA-4 and PD-1. Modern methods clinical efficacy advantages applying nivolumab, pembrolizumab atezolizumab in colorectal cancer. existing evidence base potential predictive prognostic role MSI status is summarized presented information on prospects for further development this therapeutical treatment malignant tumors.
Complete mesocolic excision (CME) appears to be a relatively new concept for colon cancer. The purpose is evaluate the results of CME with high vascular ligation (D3 lymph node dissection) right presented study identifies possible risks and advantages proposed method, as well role laparoscopic approach.The article included data from 39 patients cancer, TNM stage I-III, operated on between November 2015 December 2016 in oncoproctology Department Blokhin Cancer Research Center. analysis main...
Introduction. Malignant central airway obstruction and malignant tracheoesophageal fistula in the context of tumor development are potentially life-threatening conditions which usually require immediate intervention. Airway stenting is one safest most effective methods patency restoration patients with airways continuity fistula. Aim. To evaluate significance self-expandable metal stents palliative treatment Materials methods. Between 2017 2021 at N. Blokhin National Medical Research Center...
Background. Over the past 30 years, with development of endoscopic technologies and advent ultrasound-guided fine-needle aspiration (EuS-FnA) it has become possible to diagnose preliminary verification cardiac tumors, which in turn is an undoubted advantage detecting pathology. A rare clinical case presented: detection a tumor left atrium using high-tech techniques, particular EuS-FnA. when studying surgical material immunohistochemistry FISH hybridization, final diagnosis sounded like...
Aim. To evaluate technical features, safety and efficiency of radiofrequency ablation in tumor strictures extrahepatic bile ducts. Materials methods. An ongoing prospective observational study from September 2022 to June 2023 enrolled patients with unresectable duct tumors. Examination involved esophagogastroduodenoscopy, endoscopic ultrasound, retrograde cholangiopancreatography video choledochoscopy biopsy. Ductalradiofrequency polymeric or self-expanding metallic stent placement was...
Introduction: Colorectal cancer is one of the leading malignancies in Russia [1]. The standard approach for selected patients (pts) with locally advanced colon surgery adjuvant chemotherapy. Several studies have shown that colorectal (CRC) presence a disorder mismatch repair (dMMR) / microsatellite instability (MSI) characterized high sensitivity to immune checkpoint inhibitors. MSI dMMR CRC tend be more responsive inhibitors such as pembrolizumab, nivolumab or ipilimumab. However, there was...