A5100406024- Lung Cancer Treatments and Mutations
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- Breast Cancer Treatment Studies
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Bipolar Disorder and Treatment
- Bone Metabolism and Diseases
- Genetic Syndromes and Imprinting
- Gastric Cancer Management and Outcomes
- Genetics and Neurodevelopmental Disorders
- Radiomics and Machine Learning in Medical Imaging
- PI3K/AKT/mTOR signaling in cancer
- Cancer Immunotherapy and Biomarkers
- Infective Endocarditis Diagnosis and Management
- Diphtheria, Corynebacterium, and Tetanus
Nanjing Medical University
2020-2024
The Fifth People’s Hospital of Suzhou
2024
Jiangxi Chest Hospital
2022
China-Japan Friendship Hospital
2018-2022
Fujian Medical University
2022
Union Hospital
2022
First People's Hospital of Chongqing
2022
Jiangsu Cancer Hospital
2020
Tianjin Agricultural University
2019-2020
Merck & Co., Inc., Rahway, NJ, USA (United States)
2019
The epidermal growth factor receptor (EGFR)/PI3K/AKT signaling pathway aberrations play significant roles in breast cancer occurrence and development. However, the status of EGFR AKT1 gene copy numbers remains unclear. In this study, we showed that rates number alterations were associated with prognosis cancer. Among 205 patients, high observed 34.6% 27.8% cases by multi-gene fluorescence situ hybridization, respectively. Co-heightened EGFR/AKT1 identified 11.7% cases. No changes found 49.3%...
Background Genome‐wide association studies ( GWASs ) are used to identify genetic variants for with bipolar disorder BD risk; however, each GWAS can only reveal a small fraction of this association. This study systematically analyzed multiple data sets provide further insights into potential causal processes by integrating the results Psychiatric Genomics Consortium Phase I PGC ‐I) core human pathways and functional networks. Methods The i‐Gsea4GwasV2 program was analyze from ‐I (the came...
To evaluate PIK3CA gene mutational status in Northwest Chinese esophageal squamous cell carcinoma (ESCC) patients, and examine the associations of mutations with clinicopathological characteristics clinical outcome.A total 210 patients ESCC who underwent curative resection were enrolled this study. Pyrosequencing was applied to investigate exons 9 20 ESCCs. The outcome examined.PIK3CA exon detected 48 cases (22.9%) a non-biased database curatively resected not associated sex, tobacco use,...
To evaluate the immunohistochemical detection of epidermal growth factor receptor(EGFR) mutations using two EGFR mutation-specific monoclonal antibodies: delE746-A750 and L858R.A total 175 paraffin-embedded lung adenocarcinoma tissue samples previously genotyped by directive DNA sequencing were subject to immunostaining L858R antibodies.There was no significant difference mutation between sequence analysis and/or (33.7% vs 30.9%, P > 0.05). The overall sensitivity, specificity, positive...
To investigate the epidemiology, and hospitalization of tetanus in Suzhou, Jiangsu Province, China, focusing on severity disease, treatment, outcomes costs, to explore risk factors for severe tetanus.
ABSTRACT Background Early‐stage non–small cell lung cancer (NSCLC) is being diagnosed increasingly, and in 30% of patients, recurrence will develop within 5 years. Thus, it urgent to identify recurrence‐related markers optimize the management patient‐tailored therapeutics. Methods The eligible datasets were downloaded from TCGA GEO. In discovery phase, two algorithms, least absolute shrinkage selector operation support vector machine‐recursive feature elimination, used candidate genes....
3121 Background: ALK gene rearrangement is known as “diamond mutation”. Targeted tyrosine kinase inhibitors have perfect therapeutic effects on fusion lung cancer patients (pts), but the molecular characteristics of fusions in other cancers not been systematically elucidated. Methods: We retrospectively analyzed NGS data fusion-positive Chinese tumor pts (n = 1068) to characterize pan-cancer (excluding cancer) pts. Results: A total 66 with 13 types were screened, including 0.4% (24/5800)...
To screen the cell differentiation trajectory-related genes and build a signature for predicting prognosis of lung adenocarcinoma (LUAD).LUAD single mRNA expression profile, TCGA-LUAD transcriptome data were obtained from GEO TCGA databases. Single-cell RNA-seq used clustering pseudotime analysis after dimensionality reduction analysis, acquired differential conducted between main branches. Then, consensus was carried out on samples, GSEA performed, then differences levels immune checkpoint...
With the continuous advancement of diagnostic methods, more and early-stage Non-small cell lung cancer (NSCLC) patients are diagnosed. Although many scholars have devoted substantial efforts to investigate pathogenesis prognosis NSCLC, its molecular mechanism is still not well explained.We retrieved three gene datasets GSE10072, GSE19188 GSE40791 from Gene Expression Omnibus (GEO) database screened identified differentially expressed genes (DEGs). Then, we performed KEGG GO functional...
Abstract Background: The efficacy and safety of lapatinib plus capecitabine (LC or LX) versus trastuzumab chemotherapy in patients with HER-positive metastatic breast cancer who are resistant to is unknown. Methods: We retrospectively analyzed data from began treatment regimens beyond progression (TBP) at eight hospitals between May 2010 October 2017. Results: Among 554 had developed resistance trastuzumab, the median PFS (progression free survival) was 6.77 months LX group compared 5.6 TBP...
Abstract Background: The efficacy and safety of lapatinib plus capecitabine (LC or LX) versus trastuzumab chemotherapy in patients with HER-positive metastatic breast cancer who are resistant to is unknown. Methods: We retrospectively analyzed data from began treatment regimens beyond progression (TBP) at eight hospitals between May 2010 October 2017. Results: Among 554 had developed resistance trastuzumab, the median PFS (progression free survival) was 6.77 months LX group compared 5.6 TBP...
To study the molecular mechanisms underlying post-transcriptional regulation of secreted frizzle-related protein 1(SFRP1)gene in MC3T3-E1 murine pre-osteoblast cells using a newly constructed plasmid pMIR-REPORT-SFRP1UTR which expression luciferase was regulated by 3'UTR mouse SFRP1 gene.The mRNA and levels gene were measured real-time quantitative polymerase chain reaction Western blotting at 0, 7 10 days respectively after osteogenic differentiation induced these 50 mg/L ascorbic acid....
<p>Figure S1. Hierarchical clustering of HCC samples using differentially expressed mRNAs and/or lncRNAs. Figure S2. relative expression seven candidates. S3. Overall survival (OS) curve patients in Sh-PCR. S4. The subgroups based on the metastasis signature. S5. predicted probability LCI-Sh cohort. S6. Survival curves a subgroup single-nodular patients.</p>
<div>Abstract<p><b>Purpose:</b> The dismal outcome of hepatocellular carcinoma (HCC) is largely attributed to its early recurrence and venous metastases. We aimed develop a metastasis-related model predict prognosis.</p><p><b>Experimental Design:</b> Using microarrays, sequencing, RT-PCR, we measured the expression mRNAs lncRNAs in training set 94 well-defined low-risk (LRM) high-risk metastatic (HRM) HCC patients from Shanghai cohort. refined...
<div>Abstract<p><b>Purpose:</b> The dismal outcome of hepatocellular carcinoma (HCC) is largely attributed to its early recurrence and venous metastases. We aimed develop a metastasis-related model predict prognosis.</p><p><b>Experimental Design:</b> Using microarrays, sequencing, RT-PCR, we measured the expression mRNAs lncRNAs in training set 94 well-defined low-risk (LRM) high-risk metastatic (HRM) HCC patients from Shanghai cohort. refined...
<p>Figure S1. Hierarchical clustering of HCC samples using differentially expressed mRNAs and/or lncRNAs. Figure S2. relative expression seven candidates. S3. Overall survival (OS) curve patients in Sh-PCR. S4. The subgroups based on the metastasis signature. S5. predicted probability LCI-Sh cohort. S6. Survival curves a subgroup single-nodular patients.</p>
Abstract Background: The efficacy and safety of lapatinib plus capecitabine (LC or LX) versus trastuzumab chemotherapy in patients with HER-positive metastatic breast cancer who were resistant to is largely unknown. Methods: we retrospectively analyzed began the treatment regimen beyond progression (TBP) at eight hospitals between May 2010 October 2017. Results: Among 554 had developed resistance trastuzumab, median PFS was 6.77 months LX group compared 5.6 TBP (hazard ratio 0.804; 95% CI,...