A5081708560- Advanced Breast Cancer Therapies
- Coal Properties and Utilization
- HER2/EGFR in Cancer Research
- Hydrocarbon exploration and reservoir analysis
- Cancer Treatment and Pharmacology
- Methane Hydrates and Related Phenomena
- Breast Cancer Treatment Studies
- Ocular Disorders and Treatments
- Advancements in Solid Oxide Fuel Cells
- Facial Trauma and Fracture Management
- Atmospheric and Environmental Gas Dynamics
- Monoclonal and Polyclonal Antibodies Research
- Rock Mechanics and Modeling
- Electronic and Structural Properties of Oxides
- Brain Metastases and Treatment
- Fuel Cells and Related Materials
- Corneal Surgery and Treatments
- Coal and Its By-products
- Geoscience and Mining Technology
- Regional Economic and Spatial Analysis
- Lattice Boltzmann Simulation Studies
- Evaluation Methods in Various Fields
- International Business and FDI
- Ophthalmology and Eye Disorders
- NMR spectroscopy and applications
Zhengzhou University
2020-2025
Second Affiliated Hospital of Harbin Medical University
2025
University of Electronic Science and Technology of China
2025
Sichuan Cancer Hospital
2025
Shenyang Ligong University
2025
Affiliated Hospital of Hangzhou Normal University
2025
Harbin Medical University
2025
Hubei University of Medicine
2024-2025
Xi'an University of Science and Technology
2009-2024
Henan Cancer Hospital
2019-2024
Abstract Objective To assess the efficacy and safety of pyrotinib (an irreversible pan-HER (human epidermal growth factor receptor) inhibitor), trastuzumab, docetaxel compared with placebo, for untreated HER2 positive metastatic breast cancer. Design Randomised, double blind, placebo controlled, multicentre, phase 3 trial. Setting 40 centres in China between 6 May 2019 17 January 2022. Participants 590 female patients (median age 52 (interquartile range 46-58) years) Interventions Eligible...
1102 Background: MRG002 is a novel HER2-targeted ADC, composed of sugar-modified trastuzumab, MMAE payload and cleavable vc-linker. was effective in HER2-low expressing breast cancer preclinical studies. Hence, we conducted the phase II study to evaluate safety anti-tumor efficacy HER-low cancer. Methods: HER2 low tumor expression determined by central lab had be immunohistochemistry (IHC)1+ or 2+/ISH-. Eligible patients advanced/metastatic that failed standard therapies. administered...
Health literacy is linked to the health status of older adults and a critical component in achieving active aging. This study characterize current among combined medical nursing care institutions, as well factors that influenced this status. cross-sectional used convenience sampling method select 740 who were 16 institutions Chengdu, China, from July 2022 June 2023, using Literacy Management Scale, Social Support Rating Short Form-36 Survey. The results showed score 75.25 ± 12.33, percentage...
Root rot is one of the main reasons for yield losses red kidney bean ( Phaseolus vulgaris ) production. Pre-inoculation with Trichoderma harzianum can effectively lower incidence root rot. In this study, four treatments including CK (control), Fu13 Fusarium oxysporum ), T891 T. and + F. were arranged in a pot experiment to investigate how affected severity rot, plant growth, changes defense enzyme activity plants. Community composition diversity rhizosphere microbiota was evaluated through...
Abstract The purpose of the study was to explore microscopic and mesoscopic damage mechanisms water‐bearing coal mass in freeze‐thaw process with liquid nitrogen. For this purpose, by using a Zeiss microscope, nonmetal ultrasonic velocity detector nuclear magnetic resonance (NMR) spectrometer, changes structures surface fractures pores before after masses different moisture contents when subjected treatment nitrogen (FTTLN) were tested. result showed that under effect nitrogen, internal both...
Abstract Background: SHR-A1811 is an ADC comprised of a humanized anti-HER2 monoclonal antibody (trastuzumab), cleavable linker, and DNA topoisomerase I inhibitor payload. Here we assessed in HER2-expressing/mutated unresectable, advanced, or metastatic solid tumors. Methods: Pts were eligible if they had HER2 positive breast cancer (BC), gastric/GEJ carcinoma, low-expressing BC, NSCLC, other tumors, refractory intolerant to standard therapy. at doses 1.0-8.0 mg/kg was given Q3W (IV). The...
Under the condition of low SNR, enhancing precision parameter estimation for linear frequency modulation (LFM) signals and diminishing complexity relevant methods represent crucial challenges that are presently being confronted. To address this problem, a method LFM based on High-Resolution Representation network (HRRnet) is proposed. The fundamental concept underlying lies in employment strategy combines expansion receptive field with fusion multi-scale features. This enables efficient...
This study aimed to develop a comprehensive nomogram model by integrating clinical pathological and full-field digital mammography (FFDM) radiomic features predict the efficacy of neoadjuvant chemotherapy (NAC) in breast cancer patients, thereby providing personalized treatment recommendations. A retrospective analysis was conducted on imaging data 227 patients from 2016 2024 at Second Affiliated Hospital Harbin Medical University. The were divided into training set (n = 159) test 68) with...