A5080125376- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- BRCA gene mutations in cancer
- Genetic factors in colorectal cancer
- Hematopoietic Stem Cell Transplantation
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- RNA modifications and cancer
- Ovarian cancer diagnosis and treatment
- CRISPR and Genetic Engineering
- Retinoids in leukemia and cellular processes
- Acute Lymphoblastic Leukemia research
- Gastric Cancer Management and Outcomes
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Chronic Lymphocytic Leukemia Research
- Nutrition, Genetics, and Disease
- Fibroblast Growth Factor Research
- Kruppel-like factors research
- PARP inhibition in cancer therapy
- Prenatal Screening and Diagnostics
Moscow City Oncology Hospital №62
2016-2025
Kazan State Medical University
2025
Moscow City Hospital No 29
2015-2017
Genesis Research Institute
2014
Academy of Medical Sciences
2014
Cancer Research Center
2014
Russian Foundation for Basic Research
2014
Engelhardt Institute of Molecular Biology
2014
Genesis Foundation
2014
National Medical Research Center for Hematology
2003-2010
Echinoderm microtubule-associated protein-like 4 gene (EML4) and anaplastic lymphoma kinase (ALK) fusion was shown to be the driver of tumorigenesis in approximately 3% 5% patients with non-small cell lung cancer (NSCLC) is associated response inhibition crizotinib. However, no complete agreement regarding best diagnostic test for identification ALK rearrangements has been achieved yet.To investigate concordance, sensitivity, specificity immunohistochemistry (IHC), fluorescence situ...
Objective. To analyze the system of organization and payment for molecular genetic testing used diagnosis six most common malignancies in certain constituent entities Russian Federation to improve its effectiveness. Material methods. We prepared a list tests specified current versions clinical guidelines malignancies: cancer bronchi lungs (C34), breast (C50), ovarian (C56), prostate (C61), pancreatic (C25), chronic lymphocytic leukemia (C91.1). Information on scheduled volumes tariffs was...
Next-generation sequencing (NGS) is increasingly integrated into cancer patient management, necessitating cost-effective, reliable tests for companion diagnostics. We present the validation of Solo-test Driver panel, a custom NGS amplicon-based tool DNA analysis 34 oncogenes, addressing key clinical needs. The panel's performance was validated detecting SNVs, CNVs, and MSI. Analytical used 182 samples, while involved 130 both encompassing diverse tumor types specimen formats. panel has...
Immunohistochemical study is an integral component of modern morphologic diagnostics, providing accurate marker detection and identification molecular subtypes malignant neoplasms. A quality control system fundamental in the aspect standardizing laboratory protocols, ensuring reproducibility results increasing reliability diagnostic conclusions. Objective. To conduct a comprehensive assessment immunohistochemical studies at successive stages process (pre-analytical, analytical,...
e15647 Background: Microsatellite instability (MSI) and mismatch repair deficiency (dMMR) are key biomarkers predicting positive responses to immunotherapy in colorectal cancer (CRC). The NICHE-2 study showed promising outcomes with neoadjuvant MSI/dMMR CRC. However, real world data at this point limited. This aims assess the clinical response feasibility of CRC a single community based comprehensive center Russia, providing insights into its efficacy potential broader application...
Toxicity after blood and marrow transplantation (BMT) has interindividual variability that may be explained by common genetic polymorphisms in critical pathways. The glutathione-S-transferase (GST) isoenzymes detoxify the reactive oxygen species generated chemotherapy agents radiation. We investigated whether deletion 2 GST genes (GSTM1 GSTT1) were associated with toxicity autologous or allogeneic BMT. study population was selected from 699 consecutive BMT patients centers Buffalo, NY,...
Introduction. mBRAF mCRC has the aggressive phenotype. The incidence of such mutation in Europe and USA is around 8–14%, Asian countries – 4–8%. purpose this population-based study was to determine identifying prognostic factors pts with Russia. Materials methods. A multicenter retrospective analysis clinical data treatment results performed. main method for determining mutations a PCR. efficacy endpoint progression free survival (PFS) at 1 st line. Multivariate performed using Cox...
Non-small-cell lung cancer (NSCLC), a subtype of cancer, remains one the most common tumors with high mortality and morbidity rate. Numerous targeted drugs were implemented or are now developed for treatment NSCLC. Two genes, HER2 MET, among targets these specific therapeutic agents. Alterations in MET could lead to primary acquired resistance commonly used anti-EGFR drugs. Using current methods detecting amplifications is time labor-consuming; alternative required testing. We first...
Targeted inhibitors of the epidermal growth factor receptor (EGFR) are used for treatment non–small cell lung cancer (NSCLC). Somatic mutations in EGFR gene and key effectors EGFR-signaling pathway (KRAS, BRAF, PIK3CA) associated with sensitivity to these drugs. We developed a highly sensitive LUNG CANCER (LC)-biochip approach detection most common EGFR, KRAS, PIK3CA, BRAF mutations. The locked nucleic acid clamp PCR technique was increase assay, then allele-specific hybridization...
The overall survival (OS) results in patients with ALK-positive metastatic non-small-cell lung cancer (NSCLC) have rarely been reported. aim of this prospective-retrospective cohort study was to obtain real-world data on the use crizotinib or chemotherapy NSCLC Russia.Patients epidermal growth factor receptor-negative were screened 23 centers. To be eligible, required confirmation ALK rearrangement. Patients treated (250 mg twice daily; n = 96) investigator's choice platinum-based (n 53)....
Abstract Background: This study is a first attempt to determine frequency of gBRCAm and share sBRCAm in Russian ovarian cancer (OC) patients (pts) using next-generation sequencing (NGS) multiplex ligation-dependent probe amplification (MLPA). population known have sizable proportion “frequent” germline mutations BRCA genes, with occurrence >2% all BRCAm cases. Methods: 498 pts primary serous endometrioid OC were enrolled noninterventional OVATAR (NCT02122588). NGS testing genomic DNA...
The detection of mutations in the BRCA1/2 genes has become an integral component modern oncology. Many essential aspects related to diagnosis hereditary tumor syndromes, e.g., principles patient selection for analysis, minimal requirements DNA testing procedures, medical interventions applied mutation carriers, remain subject confusion among practicing oncologist and laboratory specialists. This work is result a discussion on various nuances BRCA1/2-diagnostics, which was organized by...
Determination of rearrangements in ALK gene patients with non-small cell lung cancer (NSCLC), proposed as a mandatory procedure most current international guidelines for the diagnosis and treatment cancer. The aim study was to conduct test by fluorescent hybridization situ (FISH) translocations involving referred testing EGFR mutations framework Society oncologists-chemotherapeutists "Improvement molecular genetic order improve efficiency anticancer treatment» www.cancergenome.ru ....
e23109 Background: The most promising method for the detection of BRCA 1/2 mutations is next-generation sequencing (NGS). There no enough data about prevalence large deletions and somatic alterations in ovarian cancer (OC). NGS technology important approach search tissue samples. Methods: 498 pts with serous endometrioid OC were enrolled OVATAR study (NCT02122588). testing BRCA1/2 blood tumor tissue, multiplex ligation-dependent probe amplification (MLPA) employed. Results: Interim analysis...
Микросателлитной нестабильностью (microsatellite instability, MSI) называется феномен накопления мутаций (делеций и инсерций) в коротких повторяющихся последовательностях ДНК. Наиболее частой причиной MSI является дефект системы репарации неспаренных оснований ДНК (mismatch repair deficiency, dMMR). Анализ MSI/dMMR используется при диагностике синдрома Линча, а также для отбора пациентов на терапию ингибиторами контрольных точек иммунного ответа. Тестирование подразумевает анализ длины...
Purpose : To evaluate the proportion of BRCA1 / 2 mutations in patients with serous and endometrioid cancer ovary, fallopian tube, peritoneum Russia, to percentage germinal somatic mutations, identify spectrum genes, clinical morphological features BRCA-associated ovarian (OC). Patients methods The study enrolled 18 years older newly diagnosed peritoneum. Biological material (blood, tumor tissue) was collected, followed by molecular genetic analysis. method detecting blood were:...
Introduction. Next-generation sequencing (NGS) is a molecular approach that can provide clinicians with comprehensive information about patient’s profile, which an important aspect of the effective application targeted therapy. Aim. To assess frequency tumor somatic mutations in non-small cell lung cancer (NSCLC) cohort Russian patients to subsequently optimize diagnostics and personalize treatment strategies. Materials methods. The study included results NGS testing from 1.400 NSCLC between...
Background: Fibroblast growth factor receptor (FGFR) signaling has been implicated to play a role in tumorigenesis. Aim of this study was evaluate rate FGFR2 amplification and preliminary patients (pts) with ovarian cancer (OC). Methods: Material from each patient advanced OC included 3 paraffin-embedded samples: primary tumor, metastatic lesion, relapse lesion. Samples were analyzed by fluorescence situ hybridization (FISH) identify level polysomy. Scoring for polysomy adopted previous...
Introduction: local treatment of metastases is an integral part colon cancer treatment. However, there not enough data on the efficacy surgical resection in patients with a BRAF gene mutation to recom‑mend this approach routine practice. We initiated retrospective multicenter study assess incidence mutations metastatic and metastasectomy group patients. Materials methods: we selected all who underwent various sites from database created as result participation 7 clinics Russian Federation....
141 Background: Metastatic colorectal cancer (mCRC) remains a challenge with significant impact on patient survival and quality of life. Over the past decade, targeted therapies have emerged as promising treatment options for mCRC, including regorafenib. While clinical trials established efficacy safety regorafenib in based CORRECT ReDos trials, real-world utilization outcomes associated this therapy gained increasing importance. This abstract presents data analysis focused use patients...