A5061965523- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Gut microbiota and health
- Cancer Genomics and Diagnostics
- Computational Drug Discovery Methods
- Nutrition and Health in Aging
- Allergic Rhinitis and Sensitization
- Diagnosis and Treatment of Venous Diseases
- SARS-CoV-2 and COVID-19 Research
- Peripheral Artery Disease Management
- Aging and Gerontology Research
- Diet and metabolism studies
- Molecular Biology Techniques and Applications
- Colorectal Cancer Screening and Detection
- CCD and CMOS Imaging Sensors
- Data-Driven Disease Surveillance
- Health Systems, Economic Evaluations, Quality of Life
- Calibration and Measurement Techniques
- Venous Thromboembolism Diagnosis and Management
- Nutritional Studies and Diet
- Ionosphere and magnetosphere dynamics
- Frailty in Older Adults
- Radiomics and Machine Learning in Medical Imaging
- Health disparities and outcomes
Federal Medical-Biological Agency
2017-2023
National Research University Higher School of Economics
2023
Traumatic brain injury (TBI) heavily impacts the body: it damages tissue and peripheral nervous system shifts homeostasis in many types of tissue. An acute compromises “brain–gut-microbiome axis”, a well-balanced network formed by brain, gastrointestinal tract, gut microbiome, which has complex effect: damage to alters composition microbiome; altered microbiome affects TBI severity, neuroplasticity, metabolic pathways through various bacterial metabolites. We modeled rats. Using...
Geriatric syndromes (GSs) and aging-associated diseases (AADs) are common side effects of aging. They affecting the lives millions older adults placing immense pressure on healthcare systems economies worldwide. It is imperative to study factors causing these conditions develop a holistic framework for their management. The so-called long-lived individuals-people over age 90 who managed retain much health functionality-could be holding key understanding implications. We analyzed status...
Microsatellite instability (MSI) is a widely studied molecular signature, which associated with long-term benefit in patients treated immune checkpoint inhibitor therapy. This approach has been proven to be effective the treatment of MSI-positive colorectal cancer (CRC). Analysis serial liquid biopsy samples allows detect changes tumor response Typically, somatic mutations are used for tracing dynamics tumor, and assessment DNA signatures such as MSI not currently these purposes. Here, we...
Next-generation sequencing (NGS) is increasingly integrated into cancer patient management, necessitating cost-effective, reliable tests for companion diagnostics. We present the validation of Solo-test Driver panel, a custom NGS amplicon-based tool DNA analysis 34 oncogenes, addressing key clinical needs. The panel's performance was validated detecting SNVs, CNVs, and MSI. Analytical used 182 samples, while involved 130 both encompassing diverse tumor types specimen formats. panel has...
Introduction. Currently in routine clinical practice, standard methods based on polymerase chain reaction (PCR) and immunohistochemical examination are used to determine microsatellite instability (MSI) deficient mismatch repair system (dMMR). MSI identification using high-throughput sequencing (next generation sequencing, NGS) is of special interest because it allows analyze a large number microsatellites simultaneously study alterations therapeutically significant genes. Aim. To validate...
MSI is a crucial biomarker for selecting CRC patients immunotherapy. Here, we analyze the first results from observational prospective trial BLOOMSI (NCT06414304), which investigated impact of MSI/dMMR testing methods and baseline tumor heterogeneity on treatment outcomes. Thirty MSI/dMMR+ patients, who were candidates immunotherapy, enrolled. Depending local test used MSI/dMMR, central PCR/IHC was performed. Baseline FFPE liquid biopsy (LB) analyzed with NGS. ORR (objective response rate)...
Aging puts the human body under an immense stress and makes it extremely susceptible to many diseases, often leading poor outcomes even death. Long-living individuals represent a unique group of people who withstood time offer abundance information on body's ability endure pressure aging. In this study, we sought identify predictors overall one-year mortality in 1641 long-living individuals. Additionally, analyzed risk factors for COVID-19-related morality, since statistics demonstrated...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, is heavily reliant on its natural ability to “hack” host’s genetic and biological pathways. The susceptibility host a key factor underlying severity disease. Polygenic risk scores are essential for assessment, stratification, prevention adverse outcomes. In this study, we aimed assess analyze predisposition severe COVID-19 in large representative sample Russian population as well build reliable but...
Abstract COVID-19 is caused by an airborne virus, SARS-CoV-2. The upper respiratory tract (URT) is, therefore, the first system to endure attack. Inhabited assemblage of microbial communities, a healthy URT wards off invasion. However, once invaded, it becomes destabilised, which could be crucial establishment and progression infection. We examined 696 samples collected from 285 patients at three time-points throughout their hospital stay 100 controls. used 16S ribosomal RNA sequencing...
INTRODUCTION: The main goals of treatment superficial thrombophlebitis lower limbs (ST LL) can be achieved using different tactics: conservative treatment, surgical intervention, and their combination.
 AIM: To perform a comparative analysis the effectiveness pharmacotherapy, crossectomy in combination with pharmacotherapy phlebectomy patients ST LL.
 MATERIALS AND METHODS: A therapeutic tactics LL was conducted (86 patients; 36 men 50 women). Group 1 received only group 2...