V. S. Yudin
A5064526079- Healthcare Systems and Public Health
- Human Health and Disease
- Gut microbiota and health
- SARS-CoV-2 and COVID-19 Research
- Liver Disease Diagnosis and Treatment
- Nutrition and Health in Aging
- Frailty in Older Adults
- Genetic Associations and Epidemiology
- RNA modifications and cancer
- Diet and metabolism studies
- Radiation Therapy and Dosimetry
- Probiotics and Fermented Foods
- Cardiomyopathy and Myosin Studies
- Genomic variations and chromosomal abnormalities
- T-cell and B-cell Immunology
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Obesity, Physical Activity, Diet
- Genomics and Rare Diseases
- Physical Activity and Health
- Child and Adolescent Psychosocial and Emotional Development
- Liver Disease and Transplantation
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Body Composition Measurement Techniques
Federal Medical-Biological Agency
2017-2025
Center for Strategic Research
2021-2025
State Research Institute of Highly Pure Biopreparations
2023
Institute of Economic Forecasting
2023
Traumatic brain injury (TBI) heavily impacts the body: it damages tissue and peripheral nervous system shifts homeostasis in many types of tissue. An acute compromises “brain–gut-microbiome axis”, a well-balanced network formed by brain, gastrointestinal tract, gut microbiome, which has complex effect: damage to alters composition microbiome; altered microbiome affects TBI severity, neuroplasticity, metabolic pathways through various bacterial metabolites. We modeled rats. Using...
Introduction Minimally invasive diagnostics based on liquid biopsy makes it possible early detection of lung cancer (LC). The blood plasma circulating cell-free DNA (cfDNA) fragments reflect the genome and chromatin status are considered as integral biomarkers biological entities for ‘cancer-of-origin’ prediction. aim this work is to create a method processing next-generation sequencing (NGS) data an interpretable binary classification model (CM), which analyzed cfDNA fragmentation features...
Aim. To study the epidemiological characteristics and changes of hypertension (HTN), as well factors associated with HTN in Russian population aged 35-74 years. Material methods. The Epidemiology Cardiovascular Diseases their Risk Factors Regions Federation-3 (ESSE-RF3) examined a representative sample years 15 regions response >70% (n=28611). Modular design questionnaire was used. Blood pressure (BP) measured twice after 5-minute rest sitting position on right arm an Omron blood monitor....
Aim. To study the prevalence of dyslipidemias and their association with various risk factors in Russian population men women aged 35-74 years 2020-2022. Material methods. This work was carried out as part Epidemiology Cardiovascular Diseases Risk Factors Regions Federation-3 (ESSE-RF3) study. The sample included 28731 living 15 regions. Hypercholesterolemia (HC) diagnosed total cholesterol (TC) ≥5,0 mmol/l, while elevated low-density lipoprotein (LDL-C) considered ≥3,0 hypertriglyceridemia...
Non-alcoholic fatty liver disease (NAFLD) is considered the most common chronic worldwide, affecting nearly 25% of global adult population. Increasing evidence suggests that functional and compositional changes in gut microbiota may contribute to development promote progression NAFLD. 16S rRNA gene next-generation sequencing widely used determine specific features NAFLD microbiome, but a complex system such as requires comprehensive approach. We three different approaches: MALDI-TOF-MS...
The gut microbiota plays an important role in maintaining human health, as well the development of various pathologies, indicated by a large amount research. One manifestations imbalance microbiome composition is appearance diseases or immune reactions, particular, atopic dermatitis (AD) and/or food allergies (FA). In this research, using 16S NGS sequencing, it was found that children with and can be characterized having higher inflammatory potential. Both groups exhibited abundance...
Geriatric syndromes (GSs) and aging-associated diseases (AADs) are common side effects of aging. They affecting the lives millions older adults placing immense pressure on healthcare systems economies worldwide. It is imperative to study factors causing these conditions develop a holistic framework for their management. The so-called long-lived individuals-people over age 90 who managed retain much health functionality-could be holding key understanding implications. We analyzed status...
Aim. To analyze the prevalence of smoking according to Epidemiology Cardiovascular Diseases and their Risk Factors in Regions Russian Federation-3 (ESSE-RF3) study, compare these data with previous two stages. Material methods. Data from following three cross sections ESSE-RF study were used: 2013-2014, 2017, 2020-2022. At first stage, probability was assessed ESSE-RF3 2020-2022 (n=28628, 35-74 years). second an analysis carried out over time using all (n=43804, 35-64 Results. In overall...
Aim. To study the problem of obesity at national level. Material and methods. The ESSE-RF3 examined a representative sample population 15 Russian regions aged 35-74 years with response >70% (n=28731). Modular design questionnaire was used. received approval from Independent Ethics Committee National Medical Research Center for Therapy Preventive Medicine. Signed informed consent obtained each participant. Body mass (BM) measured once an accuracy 100 g. height 0,5 cm in standing position...
In the example of a rat model with chronic hepatoencephalopathy (HE), changes in organ morphology rats affect balance metabolites tricarboxylic acid (TCA) cycle and glutamine–glutamate (Gln-Glu) cycle, namely α-ketoglutarate (αKG) α-ketoglutaramate (αKGM), as well enzymes associated them, ω-amidase (ωA) glutamine transaminase (GTK). This was obtained result 2–22 weeks consumption by animals hepatotoxin thioacetamide (TAA) added to drinking water at concentration 0.4 g/L. The control (n = 26)...
Aim. To study levels and types of physical activity, as well its individual socio-demographic seasonal determinants in the Russian population according to Epidemiology Cardiovascular Diseases their Risk Factors Regions Federation (ESSE-RF) study. Material methods. Data from ESSE-RF2 (2017) ESSERF3 (2020-2022) was used. The sample included 28731 men women aged 35-74 15 regions. level activity assessed using Global questionnaire (GPAQ). following socio-economic demographic characteristics were...
Aging is a natural process with varying effects. As we grow older, our bodies become more susceptible to aging-associated diseases. These diseases, individually or collectively, lead the formation of distinct aging phenotypes. Identifying these phenotypes and understanding complex interplay between coexistent diseases would facilitate personalized patient management, better prognosis, prolonged lifespan. Many studies distinguish successful frailty. However, this simple distinction fails...
Aim . To evaluate the usage of antihypertensive drugs (AHDs) and their combinations in participants aged 35 to74 years with arterial hypertension (AH) population-based study ESSE-RF3. Material methods Representative samples population to 74 from 15 regions Russia (n=28731) a response rate over 70% were examined ESSE-RF3 study. Therapy received by 9944 AH (with systolic BP ≥140 mm Hg and/or diastolic ≥90 Hg, or when subject was taking AHDs) analyzed. Information about AHDs intake (brand name...
Background . The trend towards aging of the population is global, which makes study etiology, prevention and treatment age-related disorders relevant. Increasing number studies highlights influence 25-hydroxyvitamin D deficiency on health state in older people, as well its correlation with geriatric syndromes prevalence. However, at moment it not known whether these patterns persist patients than 90 due to limited this population. Aim To assess prevalence vitamin a cohort centenarians...
The combination of radiation treatment and chemotherapy is currently the standard for management cancer patients. However, safe doses do not often provide effective therapy, then pre-treated patients are forced to repeat with already increased tumor resistance drugs irradiation. One solutions we suggest improve primary course via enhancing radiosensitivity tumors by magnetic-guided iron oxide nanoparticles (magnetite). We obtained spherical heparinized (hIONPs, ∼20 nm), characterized it TEM,...
Medicine of the 21st century has an extensive arsenal means for diagnosing diseases. High-tech equipment is able to detect pathologies without clinical manifestations during latent stage disease development. Actigraphy portable device based on accelerometer, used tracking sleep parameters, and also, well established as a tool circadian rhythms person. not alternative use polysomnography, however, it advantages in ease use, cost, size device, addition allowing long-term continuous recording...
It is known that the gut microbiota plays an important role in many biological processes of human body. However, all factors and mechanisms influencing changes composition microbiome are not fully understood. As results previous studies show, long-term food preferences play a significant modulating intestinal microbiota. At same time, reflecting peculiarities relationship vitamins, trace elements adequately characterized. Vitamins have bidirectional effect on On one hand, they influence...
Aim. To analyze the association of neighborhood infrastructure with cardiovascular diseases (CVDs) and their risk factors (RFs) in a representative all-Russian adult population sample. Material methods . Data from ESSE-RF3 study conducted 2020-2022 15 Russia regions were used. The total sample included 28731 men women aged 35-74 years. was assessed using Russian version (Neighborhood Environmental Walkability Scale (NEWS). following CVDs assessed: hypertension, obesity, hypercholesterolemia,...
We present a clinical case of familial LMNA-associated cardiomyopathy, confirmed by whole genome sequencing. The typical for lamin-associated cardiomyopathy indicates pathogenic nature the mutation in first exon LMNA gene, previously considered unknown significance. presented demonstrates radical change patient treatment strategies context widespread introduction molecular genetic research methods into practice.
BACKGROUND . More than one hundred candidate genes have been associated with longevity, including APOE, FOXO1A, GF1, IGF1, INCR, TP53, etc. Despite extensive research, the precise molecular and genetic underpinnings remain elusive due to low reproducibility of findings. Moreover, most studies focused on exomes neglected intergenic regulatory regions DNA. AIM To examine basis longevity create a prognostic model that assesses chance reaching age 90. MATERIALS AND METHODS study predictors...
BACKGROUND . A trend toward demographic aging of the population is currently observed in most countries worldwide. More and more people are achieving longevity, both due to environmental factors lifestyle, as well molecular genetic processes. Few large-scale studies have examined all contributing longevity Russia globally. Fewer them used a multi-omics approach, which could provide better insight into phenomenon by integrating genomic, epigenomic, transcriptomic metagenomic data. AIM. To...
This research aimed to evaluate the potency of preparation based on heparinized iron oxide nanoparticles (hIONPs) in combination with radiation therapy, including magnetic delivery via applied field (AMF), sarcoma and cervical cancer models. For vitro studies, cells rhabdomyosarcoma (RD), fibrosarcoma (HT1080), (HeLa S3) were treated hIONPs analyzed for survival rate hIONP uptake. Then, cell morphology, cycle, increase reactive oxygen species, mitochondria depolarization, ability form...