A5035593737- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- ATP Synthase and ATPases Research
- Acute Kidney Injury Research
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Gut microbiota and health
- Autophagy in Disease and Therapy
- Metabolomics and Mass Spectrometry Studies
- Cardiac Ischemia and Reperfusion
- Pregnancy and preeclampsia studies
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Neonatal Respiratory Health Research
- Electrolyte and hormonal disorders
- Anesthesia and Neurotoxicity Research
- Hydrogen's biological and therapeutic effects
- Tissue Engineering and Regenerative Medicine
- Dietary Effects on Health
- MicroRNA in disease regulation
- Pregnancy and Medication Impact
- RNA regulation and disease
- Extracellular vesicles in disease
- Redox biology and oxidative stress
Lomonosov Moscow State University
2016-2025
Moscow State University
2018-2025
Physico-Technical Institute
2025
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation
2018-2024
Bioengineering Center
2016
A recently discovered key role of reactive oxygen species (ROS) in mitochondrial traffic has opened a wide alley for studying the interactions between cells, including stem cells. Since its discovery 2006, intercellular mitochondria transport been intensively studied different cellular models as basis cell therapy, since potential replacing malfunctioning organelles appears to be very promising. In this study, we explored transfer from multipotent mesenchymal cells (MMSC) neural and analyzed...
Mesenchymal stem cells (MSCs) have emerged as a potent therapeutic tool for the treatment of number pathologies, including immune pathologies. However, unwelcome effects MSCs on blood coagulation been reported, motivating us to explore thrombotic properties human from umbilical cord. We revealed strong procoagulant and platelet-free plasma using rotational thromboelastometry thrombodynamic tests. A similar potentiation clotting was demonstrated MSC-derived extracellular vesicles (EVs). To...
Traumatic brain injury (TBI) heavily impacts the body: it damages tissue and peripheral nervous system shifts homeostasis in many types of tissue. An acute compromises “brain–gut-microbiome axis”, a well-balanced network formed by brain, gastrointestinal tract, gut microbiome, which has complex effect: damage to alters composition microbiome; altered microbiome affects TBI severity, neuroplasticity, metabolic pathways through various bacterial metabolites. We modeled rats. Using...
Uremic retention solutes are the compounds that accumulate in blood when kidney excretory function is impaired. Some of these toxic at high concentrations and usually known as "uremic toxins". The cumulative detrimental effect uremic toxins results numerous health problems eventually mortality during acute or chronic uremia, especially end-stage renal disease. More than 100 different increase uremia; however, exact origin for most them still debatable. There three main sources such...
Extracellular vesicles (EV) derived from stem cells have become an effective complement to the use in cell therapy of themselves, which has led explosion research into mechanisms vesicle formation and their action. There is evidence demonstrating presence mitochondrial components EV, but a definitive conclusion about whether EV contains fully functional mitochondria not yet been made. In this study, two fractions mesenchymal stromal (MSC) separated by size were examined. Flow cytometry...
There is an increasing accumulation of data on the exceptional importance mitochondria in occurrence and treatment cancer, all lines evidence for such participation, there are both energetic non-bioenergetic functional features mitochondria. This analytical review examines three specific adaptive mitochondrial changes several malignant tumors. The first feature characteristic solid tumors, whose cells forced to rebuild their energetics due absence oxygen, namely, activate fumarate reductase...
Neonatal sepsis is one of the major causes mortality and morbidity in newborns, greatly associated with severe acute kidney injury (AKI) failure. Handling newborns damage can be significantly different compared to adults, it necessary consider individuality an organism's response systemic inflammation. In this study, we used lipopolysaccharide (LPS)-mediated model study mechanisms cells neonatal adult rats. We found LPS-associated oxidative stress was more adults neonates, as judged by...
Intestinal microbiota play a considerable role in the host’s organism, broadly affecting its organs and tissues. The kidney can also be target of microbiome metabolites (especially short-chain fatty acids), which influence renal tissue, both by direct action through modulation immune response. This impact is crucial, especially during injury, because inflammation or reparative processes could affect severity resulting damage recovery function. In this study, we compared composition rat gut...
The mitochondrial membrane potential (∆Ψ) is the driving force providing electrical component of total transmembrane hydrogen ions generated by proton pumps, which utilized ATP synthase. role ∆Ψ not limited to its in bioenergetics since it takes part other important intracellular processes, leads mandatory requirement homeostasis ∆Ψ. Conventionally, living cells estimated fluorescence probes such as rhodamine 123, tetramethylrodamine, etc. However, when assessing fluorescence, possibility...
The positive effects of female sex hormones, particularly estradiol and progesterone, have been observed in treatment various pathologies. Acute kidney injury (AKI) is a common condition hospitalized patients which the molecular mechanisms hormone action are poorly characterized. In this study, we investigated influence progesterone on renal cells during ischemic injury. We performed both vivo experiments male rats vitro tubular (RTCs) obtained from kidneys intact animals different sexes....
In young rats, ischemic preconditioning (IPC), which consists of 4 cycles ischemia and reperfusion alleviated kidney injury caused by 40-min ischemia. However,old rats lost their ability to protect the IPC. A similar aged phenotype was demonstrated in 6-month-old OXYS having signs premature aging. old levels acetylated nuclear proteins were higher than however, unlike acetylation further increased after contrast Wistar age-matched no increase lysosome abundance LC3 content...
The use of stem cells is part a strategy for the treatment large number diseases. However, source original extremely important and determines their therapeutic potential. Mesenchymal stromal (MSC) have proven effectiveness when used in pathological models. it remains an open question whether chronological age donor organism affects MSC. asymmetric division cells, result which some residential acquiring non-senile phenotype, means that possess intrinsic ability to preserve juvenile...
The anti-aging strategy is one of the main challenges modern biomedical science. term "aging" covers organisms, cells, cellular organelles and their constituents. In general term, aging system admits existence nonfunctional structures which by some reasons have not been removed a clearing system, e.g., through autophagy/mitophagy marking destroying unwanted cells or mitochondria. This directly relates to old kidney normal functioning critical for viability organism. One problems in studies...