A5049387237- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immunotherapy and Immune Responses
- Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Organ Transplantation Techniques and Outcomes
- Economic and Financial Impacts of Cancer
- Protease and Inhibitor Mechanisms
- Biomarkers in Disease Mechanisms
- Cancer Mechanisms and Therapy
- Central Venous Catheters and Hemodialysis
- Free Radicals and Antioxidants
- Lung Cancer Treatments and Mutations
- Immune cells in cancer
- Hematological disorders and diagnostics
Ministry of Health of the Russian Federation
2020-2023
Rostov Research Institute of Oncology
2014-2022
Today, colorectal cancer (CRC) is the third most common and therefore an urgent problem of oncology. Despite all modern diagnostic capabilities, rates advanced cases are growing steadily. CRC was proven to be a result phased dysplastic change in colon mucosa, molecular genetic changes that determine biology tumor, its properties, morphology, disease prognosis response therapy. The following mechanisms tumor progression distinguished: chromosomal instability, microsatellite "methylator"...
Purpose of the study. Was to improve results treatment for metastatic colorectal cancer using laparoscopic surgical technologies. Patients and methods. We analyzed data on 311 patients aged 44–78 years with liver metastases; in 2005–2015, all received at National Medical Research Centre Oncology Ministry Health Russia. The main group included 161 colon resectable metastases receiving surgery; 150 same disease open surgery were controls. Results . study demonstrated that laparoscopy a...
The last decade is characterized by significant progress in the treatment of rectal cancer (reduction number relapses to 5–6 % with use prolonged radiation therapy) before surgery. greatest success has been achieved lower ampulla rectum, when it possible develop a complete clinical response tumor chemoradiotherapy. Nevertheless, requirement issues improve results upper and middle ampullar rectum an increase survival patients remain. Which makes relevant new methods, that effectiveness...
Цель. Исследовать зависимость количества циркулирующих опухолевых клеток в периферической крови у больных колоректальным раком от клинико-морфологических характеристик основного заболевания.
 Методы. В исследование был включён 91 пациент с верифицированным метастатическим Т3-4N1-2М1. Средний возраст составлял 61,5±1,7 года. Пациенты были разделены на основную группу (лапароскопическое хирургическое лечение, n=44) и контрольную (хирургическое вмешательство открытым доступом, n=47). Число...
e14260 Background: Cancer-testis antigens (CTA) can be an effective target for immunotherapy. Immunotherapeutic approaches targeting CTA in breast cancer (BC), endometrial (EC), ovarian (OC), and colon (CRC) are the incipient stages of development. The purpose our study was screening specific BC, EC, OC CRC, based on analysis transcriptional profiles CT-genes. Methods: Tumor intact tissues breast, uterus, ovaries were studied 35, 30, 20 60 patients, respectively. RNAs isolated using method...
e22095 Background: The purpose of the study was to analyze levels non-hematopoietic (CD45-CD34-) and mesenchymal (CD45-CD34-CD44+) cells in tumor tissues patients with colon cancer. Methods: Subpopulations CD45-CD34- CD45-CD34-CD44+ were determined tumor, peritumoral zone (1-3 cm from tumor) along resection line (7-10 obtained during surgery 50 stage III-IV cancer (T3-4N1-2M1). Immunophenotyping tissue samples performed by flow cytometry. Results: content showed that similar non-malignant...
ОЦЕНКА ЭФФЕКТИВНОСТИ ОСТЕОМОДЕЛИРУЮЩЕЙ ТЕРАПИИ У БОЛЬНЫХ С ГОРМОНАЛЬНО-ЗАВИСИМЫМ РАКОМ МОЛОЧНОЙ ЖЕЛЕЗЫКит О
e15508 Background: The most important stages of metastatic cascade are extravasation and invasion malignant cells their surviving in blood. vast majority circulating tumor (CTC) is destroyed by immune cells. role system which able to play not only antitumor but also prooncogenic manifested both on local systemic levels. We studied correlations between lymphocyte subsets` content blood colorectal cancer patients (II, III, IV stages) with without CTC. Methods: 60 II (n = 20), III 20) underwent...
e15500 Background: The immune response plays a key role in the oncogenesis of colorectal cancer. heterogeneity tumor environment determines need for immunogenetic profiling to identify associations with implementation tumor-specific responses purpose our study was describe expression profiles miRNAs and genes involved regulation Methods: included 18 patients (median age 66 years) diagnosed cancer who were treated at National Medical Research Centre Oncology 2018-2019. Total RNA isolated...
e23552 Background: Surgery with negative resection margins is now considered the main treatment for retroperitoneal sarcomas improving survival and quality of life patients. The most common obstacle to surgery R0 in locally advanced tumors involvement great vessels. purpose this study was analyze results surgical patients involving inferior vena cava or iliac veins. Methods: included 34 cancer who underwent tumor major vessel 2015-2021. mean size 15.5 cm (from 6 41 cm). were moderately...
e13525 Background: Cancer is a disease characterized by uncontrolled cell proliferation. DNA replication the main driving force behind proliferation in both normal development and cancer. Non-coding Y-RNAs are important factors initiating nuclei of human cells. Excessive expression Y-RNA characteristic tumors bladder, cervix, kidney, lung prostate. It has also been shown that level small RNAs formed from 3'- 5'-ends significantly higher patients with certain types cancer compared to healthy...
e16073 Background: The purpose of the study was a correlation analysis parameters local immunity and markers epithelial-mesenchymal transition (EMT) with number circulating tumor cells (CTCs) in patients stage II-IV colorectal cancer (CRC). Methods: included 60 newly diagnosed CRC. CTCs were detected Cell Search System (Janssen Diagnostics, LLC) prior to surgery. CTC≤3 considered negative, CTC > 3 – positive. After surgery, IHC infiltration immune system performed monoclonal antibodies...
3522 Background: Cancer stem cells (CSCs) capable of self-sustaining and multipotent differentiation are considered among the most important factors limiting treatment effectiveness. ALDH1 is a marker colorectal cancer (CRC) CSCs; it involved in cell proliferation, determines resistance to alkylating chemotherapeutic agents, also induces epithelial-mesenchymal transition (EMT), which increases invasive metastatic potential tumors. The purpose study was assess association between expression...
e22097 Background: A comparative analysis of lymphocyte subpopulation content in tissues different areas the large intestine patients with stage III and IV colon cancer was made. Methods: Subpopulation T-lymphocytes (T-general – CD3+, helpers/inductors CD3+CD4+, cytotoxic - CD3+CD8) B-lymphocytes (CD19+), natural killers NK (CD16+CD56+) TCRαβ TCRγδ tumor tissue, peritumoral zone (1-3 cm from tumor) along resection line (7-10 border), taken during surgical procedures, determined 73...
The purpose of the study was to analyze rectal resection outcomes in patients with cancer. Material and Methods. A retrospective analysis treatment 251 stage cT3–4aN0–2M0 cancer, who underwent transperitoneal resections rectum mesorectumectomy from 2015 2020, carried out. age ranged 27 90 years. Considering extent tumor spread, 143 (56.9 %) neoadjuvant prolonged conformal radiation therapy or chemoradiotherapy. Results. failure colorectal anastomosis observed 11 (4.4 patients, repeated...
e15623 Background: Growth factors and neoangiogenesis maintain the endothelial barrier homeostasis, form new vasculature for a tumor interact with sex hormones. Rectal sigmoid tumors are more frequent in men than women. The purpose of study was to analyze levels some growth primary adenocarcinomas (PAs) rectum (R) colon (SC) (M) women (W). Methods: Levels VEGF-A, IFR-1 IFR-2 TGF-β1 were studied cytosols tissue obtained from 78 patients (РА, st. III, G2, 49 29 aged 38-73 years, T1-3N0M0) by...
e15552 Background: Plasminogen activators play a key role in the cascade fibrinolytic system as they catalyze plasmin (P) formation from plasminogen (PG). together with are directly or indirectly involved tumor growth. The purpose of study was to compare activation primary adenocarcinomas (РА) rectum (R) and without liver metastases (LM). Methods: Tissues tumors (РА, st. III, G2, 38-74 years), their perifocal zone (PZ) resection line tissues LM (T2-3NхM1, n = 34) them (T2-3N0M0, 42) were...
e15694 Background: Familial adenomatous polyposis (FAP) is an autosomal dominant disorder, caused by germline mutations of the coli (APC) gene, with a frequency that range from 1 in 6,850 to 29,000 people. It characterized detection patient hundreds thousands polyps that, if untreated, develop into colorectal cancer. Methods: For this study, we collected specimens venous blood 13 patients (aged 22 42 years, median age 32.5) diagnosed Adenomatous Polyposis, classic form. The number their...
e14233 Background: Cancer-testis antigens (CTA) can be used in immunotherapy and for early detection of cancer. Despite numerous studies the CTA expression different tumors, their transcriptional activity its regulation colorectal cancer (CRC) remain poorly understood. The purpose study was to analyze cancer-testis genes (CT-genes) mechanisms CRC. Methods: Tumor intact tissues colon were studied 60 patients. RNAs isolated using method described by Chomczynski Sacchi (2006). REVERTA-L reagent...
e13516 Background: The colorectal cancer (CRC) incidence is steadily increasing. Moreover, the problem of its early diagnosis remains unresolved due to low specificity known tumor markers, and creating new therapeutic approaches lack a complete understanding mechanisms regulation gene expression in this oncopathology. study micro-RNAs (short non-coding RNAs that regulate expression) can be solution both problems. aim was analyze micro-RNA differential non-tumor tissues CRC patients. Methods:...
e16104 Background: Cancer-testis antigens (CTAs) can be used for immunotherapeutic approaches and early detection of malignant tumors. Despite numerous studies CTA expression in various tumors, including colon the mechanisms transcriptional activity regulation colorectal cancer (CRC) remain poorly studied. One possible gene is a change their copy number (CNV). The aim study was to analyze changes CT-genes patients with CRC. Methods: Tumor normal tissues 81 were study. DNA isolated by...
e23525 Background: Gastrointestinal stromal tumors (GIST) are rare malignant mesenchymal neoplasms of the gastrointestinal tract, diagnosis and treatment which is associated with presence mutations in c-KIT PDGFRA genes. Purpose this study was molecular genetic genotyping GIST according to clinically significant exons Methods: The included patients an immunohistochemically confirmed who underwent RRIO, Rostov-on-Don, for period 2018-2019 (n = 20, median age 63.5 years, men/women–10 people...