A5060015112- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Cancer Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Colorectal and Anal Carcinomas
- Pancreatic and Hepatic Oncology Research
- Cardiac tumors and thrombi
- Glutathione Transferases and Polymorphisms
- Cardiomyopathy and Myosin Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Biomarkers in Disease Mechanisms
- Central Venous Catheters and Hemodialysis
- Advances in Oncology and Radiotherapy
- Graphite, nuclear technology, radiation studies
- Advanced Radiotherapy Techniques
- Viral Infections and Immunology Research
- Cancer Mechanisms and Therapy
- Organ Transplantation Techniques and Outcomes
- Hematological disorders and diagnostics
- Venous Thromboembolism Diagnosis and Management
- Management of metastatic bone disease
- Sarcoma Diagnosis and Treatment
Amur State Medical Academy
2023
Rostov Research Institute of Oncology
2021-2022
e15508 Background: The most important stages of metastatic cascade are extravasation and invasion malignant cells their surviving in blood. vast majority circulating tumor (CTC) is destroyed by immune cells. role system which able to play not only antitumor but also prooncogenic manifested both on local systemic levels. We studied correlations between lymphocyte subsets` content blood colorectal cancer patients (II, III, IV stages) with without CTC. Methods: 60 II (n = 20), III 20) underwent...
УДК 616.34-006.6ГЕНЕТИЧЕСКИЕ И ЭПИГЕНЕТИЧЕСКИЕ ПРЕДИКТОРЫ ЭФФЕКТИВНОСТИ ЛУЧЕВОЙ ТЕРАПИИ ОПУХОЛЕЙ ПРЯМОЙ КИШКИ Кутилин Д.С., Гусарева М.А., Кошелева Н.Г., Павлятенко И.В., Савченко Д.А., Габричидзе П.Н., Гварамия А.К., Шляхова О.В., Бабенков О.Ю
e15500 Background: The immune response plays a key role in the oncogenesis of colorectal cancer. heterogeneity tumor environment determines need for immunogenetic profiling to identify associations with implementation tumor-specific responses purpose our study was describe expression profiles miRNAs and genes involved regulation Methods: included 18 patients (median age 66 years) diagnosed cancer who were treated at National Medical Research Centre Oncology 2018-2019. Total RNA isolated...
e20514 Background: Non-small cell lung cancer (NSCLC) accounts for 85% of all cancers and remains the most commonly diagnosed human neoplasm with a poor prognosis. Significantly improving clinical course NSCLC, EGFR tyrosine kinase inhibitors are effective only against tumors carrying activating mutations in gene, their frequency varies depending on patient population. The aim study was to analyze retrospective group Crimean patients advanced NSCLC presence gene aberrations association...
e23552 Background: Surgery with negative resection margins is now considered the main treatment for retroperitoneal sarcomas improving survival and quality of life patients. The most common obstacle to surgery R0 in locally advanced tumors involvement great vessels. purpose this study was analyze results surgical patients involving inferior vena cava or iliac veins. Methods: included 34 cancer who underwent tumor major vessel 2015-2021. mean size 15.5 cm (from 6 41 cm). were moderately...
3522 Background: Cancer stem cells (CSCs) capable of self-sustaining and multipotent differentiation are considered among the most important factors limiting treatment effectiveness. ALDH1 is a marker colorectal cancer (CRC) CSCs; it involved in cell proliferation, determines resistance to alkylating chemotherapeutic agents, also induces epithelial-mesenchymal transition (EMT), which increases invasive metastatic potential tumors. The purpose study was assess association between expression...
НАРУШЕНИЯ В РЕГУЛЯТОРНОЙ СЕТИ КОНКУРЕНТНО-ВЗАИМОДЕЙСТВУЮЩИХ РНК И РАДИОРЕЗИСТЕНТНОСТЬ ОПУХОЛЕЙ ПРЯМОЙ КИШКИ
The classifications of the World Health Organization, European Society Car-diology and American Heart Association indicate existence several phenotypes myocardial non-compaction (MnC) with specific structural functional abnormalities. MnC+dilated cardiomyopathy (DCM) phenotype is considered one most severe variants. Disputes continue about whether to regard MnC as an independent disease or a consequence DCM heart failure. In other words, remains mysterious diseases. As illustration...
e17507 Background: The purpose of this study was to evaluate perirectal blocks in prevention radiation-induced rectal injuries patients with cervical cancer. Methods: included 18 diagnosed stage III cancer (T3bNxM0) receiving chemoradiotherapy. All showed pronounced inflammatory and dystrophic changes tissue planes organs the small pelvis due comorbidities (diabetes mellitus, hypertension, pelvic varicose veins, proctitis, adhesive processes reducing chemoradiotherapy effectiveness impaired...
e17506 Background: Ionizing radiation inhibits the immunological reactivity of body and system nonspecific antitumor resistance in patients with cervical cancer (CC). The purpose this study was to activate using visible electromagnetic CC receiving chemoradiotherapy. Methods: included 30 patients, mean age 61 years, stage IIIb (T 3b N x M 0 ). main group (n = 15) received standard chemoradiotherapy (CRT): irradiation primary focus 80 Gy, lymphatic paths 55 radiomodification cisplatin...
e16243 Background: Surgical treatment is considered the main for pancreatic cancer improving patient survival. The most common obstacle to surgery with R0 resection involvement of great vessels. Recently, venous resections have been increasingly performed this type tumors. Our purpose was evaluate radicality surgical and postoperative morbidity in patients locally advanced cancer. Methods: study included (T3 N0-1 M0) damage segment (portal vein system) confirmed by CT angiography. Results:...
e15613 Background: Colorectal cancer (CRC) is the third most commonly diagnosed cancer. More than 60% of all cases CRC are colon (CC). The role individual units immune system in development this tumor ambiguous. purpose study was to characterize local populations and subpopulations immunocompetent cells colorectal with different locations. Methods: included 50 CC (adenocarcinoma) patients aged 35-86 years, women n = 26 (52%). Stage I tumors were registered 4 (8%), stage II 25 (50%), III 21...
e15502 Background: The purpose of this study was a comparative analysis the expression miRNAs in tumor and circulating cells (CTCs) colon cancer (CC). Methods: Expression seven (hsa-let-7i-5p, hsa-miR-126-5p, hsa-miR-143-3p, hsa-miR-21-5p, hsa-miR-25-3p, hsa-miR-26a-5p, hsa-miR-92a-3p) were determined by real-time PCR tumors 200 patients with stage II-IV CC compared normal tissue; levels CTCs CellSearch, at CTC > 3, isolated same studied them. Results: Tumor tissues showed statistically...
e15503 Background: The purpose of this study was to analyze the effect CD44+ and CD133+ co-expression in cancer stem cells (CSCs) on lymphocytic microenvironment colon (CC). Methods: 200 CC patients received surgery as first stage treatment. percentage CSCs with expression and/or markers studied tumor homogenates by flow cytometry, well some indicators local immunity (CD3+, CD4+, CD8+, T regs (CD4+CD25+CD127dim), CD19+, PD-1, PD-L1, Th0, Tm, CD16/56+ immunophenotypic characteristics (PD-L1,...
e15501 Background: The purpose of this study was to demonstrate the importance circulating tumor cells (CTCs) in formation immunosuppression colon cancer. Methods: 200 patients with stage II-IV cancer underwent surgery as first treatment. Blood levels CTCs were determined before by flow cytometry using CellSearch method (the sample considered positive > 3), well some indicators innate immunity (NK cells, neutrophilic and monocytic phagocytosis). Results: Regardless stage, had...
e16221 Background: Restoration the hepatic arterial blood flow is required in traumatic or iatrogenic damage to artery and its branches, as well planned resection of with subsequent reconstruction. Various ways have been proposed solve this problem: ligation which associated an extremely high mortality rate, reaching 70%, need for extensive liver resections; portal vein arteriolization; transposition splenic severe complications (heart attack, abscess) replacement sometimes are not available...
e16220 Background: Patients with pancreatic cancer are at high risk for venous thrombosis. Thrombotic episodes most often recorded the tumor diagnosis, surgical treatment and chemotherapy courses, or disease recurrence. This complication postpones beginning of underlying increases mortality rate patients. The purpose study was to reveal relationship between clinical characteristics disorders hemostasis indicators in patients cancer, identify predictors Methods: 246 diagnosed were recruited...
e15510 Background: Tumor is a structure where malignant cells interact, among others, with of the adaptive and innate immune systems largely determining tumor microenvironment. The role TILs in disease prognosis has been shown. amount CTCs one factors that significantly affect risk rate metastasis. purpose study was to assess an association between peripheral blood patients various stages colorectal cancer (CRC). Methods: included 299 (aged 42-86 years, mean age 64.2±1.7) stage II-IV CRC...
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