A5076421854- Glutathione Transferases and Polymorphisms
- Cancer, Hypoxia, and Metabolism
- Redox biology and oxidative stress
- Growth Hormone and Insulin-like Growth Factors
- Biochemical effects in animals
- Free Radicals and Antioxidants
- Melanoma and MAPK Pathways
- Social and Behavioral Studies
- bioluminescence and chemiluminescence research
- Sarcoma Diagnosis and Treatment
- Chemical and Physical Studies
- Computational Drug Discovery Methods
- Neurological Disorders and Treatments
- Cancer Research and Treatments
- Biomarkers in Disease Mechanisms
- Estrogen and related hormone effects
- Metastasis and carcinoma case studies
- Retinoids in leukemia and cellular processes
- Gastric Cancer Management and Outcomes
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Treatment and Pharmacology
- Nutrition and Health in Aging
- Chemical Reactions and Isotopes
- Cholinesterase and Neurodegenerative Diseases
- HER2/EGFR in Cancer Research
Rostov Research Institute of Oncology
2014-2023
Ministry of Health of the Russian Federation
2020-2023
The aim is to study some mechanisms of regulation apoptosis and self-organization in the mitochondria heart cells female mice during growth experimental melanoma B16/ F10 linked with chronic neurogenic pain as comorbid pathology.
Purpose of the study . To evaluate features free radical oxidation (FRO) and principal enzymatic non-enzymatic links antioxidant defense in proliferating tissues benign myoma malignant endometrioid adenocarcinoma (EA) with varying degrees differentiation. Patients methods. who received surgical treatment for EA ( n = 42) uterine 14) were examined. stage Ia 26) Ib 16) disease selected. 16 patients had highly differentiated (G1) EA, 12 moderately (G2) 14 low-differentiated (G3) EA. The...
Purpose of the study. An analysis indices free radical oxidation and respiration mitochondria heart cells in a malignant process presence diabetes mellitus chronic neurogenic pain experimental animals. Materials methods. The study included outbred female rats (n=32) С57ВL/6 mice (n=84). Experimental groups were: intact group 1 (n=8), control (n=8) with (DM), comparison standard subcutaneous transplantation Guerin’s carcinoma, main carcinoma transplanted after week persistent hyperglycemia. 2...
Purpose of the study . Was to analyze changes in pathophysiological parameters transplantable tumor growth and functional activity hypothalamic-pituitary-thyroid axis (HPT) rats both sexes with Guerin's carcinoma presence induced hypothyroidism. Materials methods The dynamics average life span were assessed white alley Guerins transplanted subcutaneously on background thyreostatic RIA (radioimmune assay) ELISA (enzyme-linked immunosorbent used determine levels thyroid hormones blood samples,...
Purpose — to investigate the dynamics of content antioxidant enzymes superoxide dismutase 1 (SOD1), glutathione peroxidase (GPO1), reductase (GR) and lipid peroxidation products diene conjugates (DC), malondialdehyde (MDA) in spleen liver during latent period growth metastasis experimental tumor. Materials methods . Using 28 white male rats, a model hematogenous was created by transplanting sarcoma 45 cells (S45) into spleen, previously lead out under skin 3 weeks before. Previously,...
According to modern concepts cancer is a complex dynamic system having multiple relationships with both the immediate environment and remote nonmalignant tissues organs. Changes in redox balance them can result disruption of normal tissue control. Understanding biology processes particular tumor its surroundings, their functioning mechanisms necessary for development new anti-cancer strategies based on effects state surrounding tissue. Thus aim this work was investigate activity enzymatic...
Aim. Our aim has been to develop an experimental model of the tumor growth against background hypothyroidism in rats both genders order study possible influence made by on progression malignant tumors various histological types. Materials and methods. In our studies we have used 100 outbred albino genders, with individual body mass 150-180 g. The female (n=30) male received Mercazolil at a day dosage 2,5 mg/100g weight for 30 days. After treated rodents had confirmed, one group them (15...
Aim. To study the levels of reduced and oxidized glutathione (GSH GSSG, respectively), as well thiol status in gastric cancer (GC) tumors various histological types grades. Materials methods. The indicators were determined by ELISA methods tumor, peritumoral visually intact tissues obtained during surgery from 52 patients with GC: 18 had a G1-2 adenocarcinoma (AC), 8 G3 AC, 6 signet ring cell (SRCC), 14 combined lesions (CGL) – AC fragments, component undifferentiated cancer, G4. Results. In...
<h3>Introduction/Background</h3> The purpose of the study was a comparative analysis intensity lipid peroxidation (LPO) and antioxidant system in blood cervical cancer (CC) patients receiving treatment with without xenon therapy. <h3>Methodology</h3> included 20 CC (T1B-T2BN<sub>x</sub>M0). After extended panhysterectomy, 13 received 5 sessions inhalation therapy, while 7 were controls. Blood levels malonic dialdehyde (MDA) diene conjugates (DC), activity superoxide dismutase (SOD), catalase...
Purpose of the study . The purpose was to evaluate dynamics parameters malondialdehyde (MDA), reduced glutathione and antioxidant enzyme activity in patients with advanced cervical cancer (CC) receiving anticancer treatment dendritic cell vaccine (DCV). Patients methods Levels were studied 27 aged 27–65 years primary recurrent CC chemotherapy (CT) DCV or as monotherapy at a dose 10 million cells intradermally once week. same indices 20 healthy women from comparison group. Results majority...
The use of metal nanoparticles (NPs) for cancer treatment requires careful examination their biological effects. aim this study was to determine parameters oxidative processes in the blood tumor-bearing animals treated with metallic iron NPs only. markers antioxidant status and accumulation lipid peroxidation products were measured erythrocytes plasma rats Pliss lymphosarcoma (PLS) intact rats. PLS eight times (at a dose 1.25 mg/kg bw (main group), control group received saline (0.3 ml). In...
ПОКАЗАТЕЛИ ОКИСЛИТЕЛЬНОГО МЕТАБОЛИЗМА В КРОВИ БОЛЬНЫХ С РАЗНЫМ ГИСТОТИПОМ ОПУХОЛЕЙ ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ Горошинская И.А. 1 , Франциянц Е.М. Алейнов В.И. Немашкалова Л.А. Черярина Н.Д. Кит О
Purpose of the study . Exploring erythrocyte glutathione system functioning in patients with gastric cancer a comparative aspect, depending on tumor histotype and disease prevalence. Patients methods The included 89 cancer, divided into 6 groups tumor. Separately, results were analyzed T4 status according to TNM at stage 4. content reduced activity glutathione-dependent enzymes erythrocytes patients' blood studied by conventional spectrophotometric methods. Statistical processing was carried...
Purpose of the study. Studying dynamics factors apoptosis in mitochondria skin and tumors cells female mice with melanoma growth stimulated by chronic neurogenic pain. Material methods. The study included С57ВL/6 (n=56) a model pain (CNP) produced bilateral sciatic nerve ligation transplanted B16/F10 melanoma. After 1–3 weeks tumor growth, levels cytochrome C, caspase‑9 (Bioscience, Austria), Bcl‑2 (Thermo Fisher Scientific, AIF (RayBiotech, USA) were determined ELISA, calcium (Са 2+ )...
Purpose of the study . To intensity lipid peroxidation (LPO) and activity antioxidant protection components in tumor tissues, peritumoral zone conditionally healthy skin tissue basal cell carcinoma, depending on type growth, gender patients, presence concomitant diseases. Materials methods. Tissues from 34 patients with carcinoma (BCC) were studied, including 17 women (10 superficial growth 7 solid growth) men (5 12 respectively). We used flaps obtained during operations 10 without malignant...
Purpose: A comparative study of the content lipid peroxidation (LPO) products and activity main antioxidant enzymes in blood plasma patients with brain metastases (BM) under various radiotherapeutic treatment options. Material methods: The included 37 BM. Three groups were formed: Control group (12 patients), which stereotactic radiotherapy a single focal dose 6 Gy to total 30 was performed on place removed metastasis; Main No. 1 (6 patients) — after session preoperative radiosurgery 10-15...
Aims: to study the content of regulatory peptides in hypothalamus and pituitary gland, as well sex steroids gonads rats both sexes with Guerin’s carcinoma against background hypothyroidism. Materials methods. Our experiment was performed white outbred induced hypothyroidism, which transplanted. In 1% homogenates 10% animals from main reference groups, levels GnRH (Casabio, China) were determined by ELISA method using standard kits, LH, FSH, estradiol (E2), testosterone (T) progesterone (P4)...
Introduction. The proven significance of free radical disorders in oncopathology determines the relevance their study soft tissue sarcomas (STS), which are characterized by a tendency to recurrence and high mortality patients. Aim. To indicators oxidation antioxidant protection blood lymphocytes primary recurrent STS, depending on sex age Materials methods. In 51 patients with T2bN0M0 (17 men 34 women) (14 20 relapses, level lipid peroxidation products – malondialdehyde diene conjugates,...
e17508 Background: Cervical cancer (CC) is one of the main causes death among patients with gynecological tumors. As a rule, die from relapses and metastases which rates reach 30-45%. According to research data, treatment distant ineffective, half them within 9.7 months, while average survival 15.9±0.26 months. The development many pathological processes considered be associated an increase in free-radical reactions leading oxidative damage various biomolecules. purpose study was analyze...
Introduction . Cytochrome C in mitochondria transfers electrons from complex III to IV, and it is a signaling molecule the apoptosis realization. The objective was evaluate level of cytochrome cell various organs female mice with standard stimulated growth experimental B16/F10 melanoma. Methods materials experiment performed on C57BL/6 (n=168). groups were: intact animals (n=21); controls model chronic neurogenic pain (CNP) (n = 21); group M — melanoma transplantation (n=63), CNP + 3 weeks...
The aim is to study the effect of comorbid pathology, namely, diabetes mellitus, on free radical oxidation in mitochondria heart cells female rats with experimental Guerin carcinoma.
Introduction. The application of efferent therapy (extracorporeal therapy) now becomes relevant due to the individual intolerance various drugs, side effects a great many which is especially important when treating onco-gynecological pathology, often accompanied by development endogenous intoxication. purpose study evaluation state system endotoxemia in gynecological cancer patients under treatment certain types chemotherapy with use extracorporeal approaches. Material and Methods. In blood...
Muscle-non-invasive bladder cancer (MNIBC) accounts of 70% malignant lesions this localization and has a high rate recurrence complications after treatment that requires improvement the management such patients. The developed modification adjuvant intravesical chemotherapy (IVCT) necessitates evaluation endotoxemia adequacy antioxidant protection purpose study is assessment indices reflect functional state albumin, severity endogenous intoxication (EI) free radical oxidation in blood MNIBC...
To study the intensity of lipid peroxidation (LPO) and activity main antioxidant protection enzyme: superoxide dismutase (SOD) in heart tissues tumors rats both genders with Guerin’s carcinoma (GC) tumor growth against background diabetes mellitus (DM). Materials methods. Our research work was carried out 80 outbread albino male female rats, divided into 4 groups, 10 animals each gender a group. The two namely, an intact animal group treated alloxan DM (with 5-fold increase glucose levels)...
The aim of this research work is to study the cAMP level in cardiac mitochondria and serum С57ВL/6 strain mice both genders under independent melanoma В16/F10 growth versus linked chronic neurogenic pain (CNP). Materials methods. Mice (n=336) have been grouped as follows: intact group (♂n=21; ♀n=21), reference ♀n=21) with reproduced CNP model, comparison (♂n=63; ♀n=63) include В16/F10, main test cover against background. Upon expiration 1 week, 2 3 weeks growth, animals above experimental...