A5063208691- Cancer, Hypoxia, and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Estrogen and related hormone effects
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Cancer Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Protease and Inhibitor Mechanisms
- Thyroid Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- Endometrial and Cervical Cancer Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Angiogenesis and VEGF in Cancer
- Glutathione Transferases and Polymorphisms
- Biomarkers in Disease Mechanisms
- Lung Cancer Treatments and Mutations
- Radiopharmaceutical Chemistry and Applications
- Metastasis and carcinoma case studies
- Prostate Cancer Treatment and Research
- Pain Mechanisms and Treatments
- Metabolism, Diabetes, and Cancer
- Cancer Research and Treatments
- Ovarian cancer diagnosis and treatment
- Melanoma and MAPK Pathways
- Redox biology and oxidative stress
Ministry of Health of the Russian Federation
2014-2025
Rostov Research Institute of Oncology
2014-2023
National Medical Research Center of Cardiology
2023
The aim is to study some mechanisms of regulation apoptosis and self-organization in the mitochondria heart cells female mice during growth experimental melanoma B16/ F10 linked with chronic neurogenic pain as comorbid pathology.
Abstract Non-small cell lung cancer (NSCLC) has limited treatment options. Expression of the RNA-binding protein (RBP) Musashi-2 (MSI2) is elevated in a subset non-small tumors upon progression, and drives NSCLC metastasis. We evaluated mechanism MSI2 action to gain therapeutically useful insights. Reverse phase array (RPPA) analysis MSI2-depleted versus control Kras LA1/+ ; Trp53 R172HΔG/+ lines identified EGFR as MSI2-regulated protein. expression activity an line panel was studied using...
The purpose of this study was to establish a model uterine carcinoma in female laboratory rats by transplanting Guerin directly into the horn. Material and Methods . Fifteen nonlinear white weighing 250 ± 25 g served as subjects surgical intervention. all operative interventions were performed under xylazine-zoletil anesthesia. Female laparotomized aseptic conditions using incision length 2 cm, tumor suspension containing 2.5-3.5×10 6 cells injected lumen right horn an intravenous catheter...
Введение. Меланома представляет все больший интерес для исследований, особенно по мере выяснения конкретных биологических путей ее развития и прогрессирования. Важную роль в процессах меланомы играет митохондриальный метаболизм, перестройки которого влияют на выживаемость злокачественных клеток. Цель. Изучение способности митохондрий, изолированных из меланомы, образовывать опухолевые структуры организме животных. Материалы методы. В эксперименте использовали 17 самцов мышей линии С57ВL/6...
Purpose of the study . To evaluate features free radical oxidation (FRO) and principal enzymatic non-enzymatic links antioxidant defense in proliferating tissues benign myoma malignant endometrioid adenocarcinoma (EA) with varying degrees differentiation. Patients methods. who received surgical treatment for EA ( n = 42) uterine 14) were examined. stage Ia 26) Ib 16) disease selected. 16 patients had highly differentiated (G1) EA, 12 moderately (G2) 14 low-differentiated (G3) EA. The...
Purpose of the study . To create a model tumor growth in uterus context diabetes mellitus (DM) and to its morphological features. Materials methods The was created using female non-linear white rats weighing 180–220 g ( n = 15). Alloxan prelim inarily injected at dose 150 mg/kg weight intraperitoneally once (inducing DM). Twenty-four hours after injection, were anesthetized with xylazine-zolazepam, suspension Guerin's carcinoma cells transplanted into uterine horn. Blood glucose levels, body...
Purpose of the study . To examine dynamics content thioredoxin 1 (Trx1), reductase (TR1), and glutathione S-transferase Pi (GST Pi) in spleen liver during latent period growth metastasis C45, which occurs approximately one to two weeks after tumor transplantation. Materials methods The experiment was conducted on 28 male rats a white, nonlinear strain. A model hematogenous created by transplanting sarcoma 45 (C45) into spleen, previously dislocated under skin three prior commencement...
Purpose of the study . To examine influence specific factors on apoptosis process in mitochondria cells located various regions colon, with a focus patients both sexes. Patients and methods The included results obtained from 132 T2–3N0M0 colon cancer, comprising 52 women 80 men. Mitochondria were isolated human intestinal tumor tissue using differential centrifugation. concentration cytochrome C (ng/mg protein), AIF (pg/mg Bcl-2 calcium (mM/mg protein) determined. Results In men, level...
Hyperthyroidism is caused by increased synthesis and secretion of thyroid hormones. It increases the risk some malignant neoplasms. The gland parathyroid glands have a common embryological origin. Parathyroid hormone (PTH) secreted cells glands. aim study was to determine level in blood serum, tumor, skin thyroid/parathyroid complex C57BL/6 mice both sexes with Lewis lung carcinoma induced hyperthyroidism. Materials Methods. (n=112) were used trial. animals divided into experimental groups:...
Background: Serous endometrial carcinoma (SEC) and clear cell (CCC) are rare forms of cancer (EC) characterized by an aggressive clinical course. Purpose the study: Evaluation differences in content vascular endothelial growth factors (VEGF) their soluble receptors (sVEGF-R) tumor tissue blood patients with various types EC. Materials methods: The study included 21 CCC (71.5 % stage I–II, 28.5 III–IV), as well 20 SEC (80 III–IV). All had high grade G3 tumors. control group endometrioid...
Introduction. The development of malignant tumors the uterine body is influenced by many factors, including disturbances in mitochondrial genome. Abnormalities regulation genome lead to a decrease oxidative phosphorylation, as well inhibition apoptosis pathway. To develop effective minimally invasive methods for diagnosing endometrial adenocarcinoma and fibroids, screening molecular markers blood plasma necessary. Such may be gene copy number levels microRNA transcripts. These indicators are...
ВОЗРАСТНЫЕ ОСОБЕННОСТИ ФИБРИНОЛИТИЧЕСКОЙ СИСТЕМЫ КРОВИ У ЖЕНЩИН С ЛЕЙОМИОМАМИ МАТКИКаплиева И.В., Захарченко В
Purpose of the study. An analysis indices free radical oxidation and respiration mitochondria heart cells in a malignant process presence diabetes mellitus chronic neurogenic pain experimental animals. Materials methods. The study included outbred female rats (n=32) С57ВL/6 mice (n=84). Experimental groups were: intact group 1 (n=8), control (n=8) with (DM), comparison standard subcutaneous transplantation Guerin’s carcinoma, main carcinoma transplanted after week persistent hyperglycemia. 2...
Purpose of the study . Was to analyze changes in pathophysiological parameters transplantable tumor growth and functional activity hypothalamic-pituitary-thyroid axis (HPT) rats both sexes with Guerin's carcinoma presence induced hypothyroidism. Materials methods The dynamics average life span were assessed white alley Guerins transplanted subcutaneously on background thyreostatic RIA (radioimmune assay) ELISA (enzyme-linked immunosorbent used determine levels thyroid hormones blood samples,...
Musashi-2 (MSI2) is a member of RNA-binding protein family that regulates mRNA translation numerous intracellular targets and influences maintenance stem cell identity. This study assessed MSI2 as potential clinical biomarker in non-small lung cancer (NSCLC).The current included 40 patients with NSCLC, whom one presented stage 1, 14 II, 15 III, 10 had IV. All received standard care treatments. patient samples were obtained before treatment started. We used immunohistochemical (IHC) approach...
The increase in patients with multiple primary malignant tumors (MPMT) determines the need to study their pathogenesis. An important role functioning of brain neurons belongs norepinephrine (NA) and dopamine (DA), which can contribute tumor development immunodeficient mice both sexes.
 purpose our work was a comparative analysis content cerebral cortex sexes during isolated combined growth (MPMT model) experimental tumors.
 Materials Methods. 56 BALB/c Nude were divided into 7...
СОДЕРЖАНИЕ ФАКТОРОВ РОСТА И ИХ РЕЦЕПТОРОВ В ОБРАЗЦАХ ОПУХОЛИ, ПЕРИФОКАЛЬНОЙ ЗОНЕ ЛИНИИ РЕЗЕКЦИИ У БОЛЬНЫХ БАЗАЛЬНОКЛЕТОЧНЫМ РАКОМ КОЖИ Бандовкина В.А. 1 , Франциянц Е.М. Ларина Н.И. Пржедецкий Ю.В. Каплиева И.В. Погорелова Ю.А
Purpose of the study . To determine thyroid status primary cancer patients in early stages uterine body cancer, kidney breast skin melanoma and lung without a history endocrine pathology. Patients methods The content levels thyroid-stimulating hormone (TSH), hormones (THs) T4 T3 total free forms were determined blood serum by RIA method 132 with (average age 55 years). comparison group consisted practically healthy donors. Results Only melanoma, TSH reduced 1.5 times ( p < 0.05). was...
Uterine cancer (UC) is the third most common in women Russia. Knowledge of age-specific features fibrinolytic system patients with UC can be useful terms improving its pathogenetic therapy. Aim study was to investigate peculiarities content and activity some components blood different age groups. Material methods . 30 healthy (donors) 56 uterine T1a-2N0M0, adenocarcinoma G1–G3 were divided into subgroups according age: reproductive, perimenopause menopause. ELISA urokinase (u-PA), receptor...
Purpose — to investigate the dynamics of content antioxidant enzymes superoxide dismutase 1 (SOD1), glutathione peroxidase (GPO1), reductase (GR) and lipid peroxidation products diene conjugates (DC), malondialdehyde (MDA) in spleen liver during latent period growth metastasis experimental tumor. Materials methods . Using 28 white male rats, a model hematogenous was created by transplanting sarcoma 45 cells (S45) into spleen, previously lead out under skin 3 weeks before. Previously,...