A5076249279- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Venous Thromboembolism Diagnosis and Management
- Acute Myeloid Leukemia Research
- Inflammatory Biomarkers in Disease Prognosis
- Bone health and treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Immunotherapy and Biomarkers
- Erythrocyte Function and Pathophysiology
- Monoclonal and Polyclonal Antibodies Research
- Blood groups and transfusion
- Endometrial and Cervical Cancer Treatments
- Cancer Treatment and Pharmacology
- Glycosylation and Glycoproteins Research
- HIV, TB, and STIs Epidemiology
- Immunodeficiency and Autoimmune Disorders
- Sarcoma Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Glutathione Transferases and Polymorphisms
- Reproductive tract infections research
- Cutaneous lymphoproliferative disorders research
- Viral-associated cancers and disorders
- Medical Imaging and Pathology Studies
Ministry of Health of the Russian Federation
2019-2024
Rostov Research Institute of Oncology
2016-2024
ВОЗРАСТНЫЕ ОСОБЕННОСТИ ФИБРИНОЛИТИЧЕСКОЙ СИСТЕМЫ КРОВИ У ЖЕНЩИН С ЛЕЙОМИОМАМИ МАТКИКаплиева И.В., Захарченко В
Purpose : to study the level of LAG-3 expression on B-lymphocytes and feasibility using it as a marker for predicting response therapy in patients with chronic lymphocytic leukemia (CLL). Material Methods . The included 40 newly diagnosed CLL. All were divided into two groups: group I: Binet stage A, who did not receive II: C, received immunochemotherapy RB FCR regimes. According treatment regimen hematological therapy, 4 subgroups distinguished: IIA-RB, IIA-FCR, IIB-RB, IIB-FCR. control...
Purpose of the study . To evaluate features morphological and immunophenotypic characteristics lymphoid population with different restriction light chains immunoglobulins in patients chronic lymphocytic leukemia (CLL). Materials methods The included 30 CLL aged 47–79 years (20 men 10 women). All underwent a General clinical blood test (SysmexXE 2100, Japan), examination bone marrow (BioVision; Micros, Austria), immunophenotyping peripheral by flow cytofluorometry (Navios10/3, Beckman...
e17025 Background: The purpose of the study was to analyze frequency and time recurrence development in patients with cervical cancer (CC) after primary treatment. Methods: Clinical data 1048 histologically verified stage I-IV were studied retrospectively. 236 (22.5%) developed recurrences. Frequency recurrences compared patients’ age, disease stage, morphological structure type growth tumor; DFS analyzed. Results: Age newly diagnosed 20-75 years, mean age 50.5±1.3; almost a third cases...
Aim. To study the glomerular filtration rate (GFR) dynamics calculated by creatinine and cystatin C during induction immunochemotherapy in patients with newly diagnosed diffuse large B-cell lymphoma order to objectify method for estimation. Materials methods. The open longitudinal included 39 who received specialized treatment at Oncohematology Department of National Medical Research Centre Oncology (Rostov-on-Don) 2021. Patients according R-CHOP regimen (rituximab, doxorubicin,...
AIM. To analyze the bone marrow lymphocyte subpopulation based on targeted assessment of PD-1, PD-L1, and LAG-3 marker expression in chronic lymphocytic leukemia (CLL) patients with different responses to chemotherapy. MATERIALS & METHODS. In 33 CLL patients, antigen В-, Т-, NK-cells (BM) was analyzed by flow cytofluorometry prior treatment after 6 cycles chemotherapy rituximab. Patients were aged 58–68 years (median 64 years); there 14 women 19 men. Hematologic response assessed...
Uterine cancer (UC) is the third most common in women Russia. Knowledge of age-specific features fibrinolytic system patients with UC can be useful terms improving its pathogenetic therapy. Aim study was to investigate peculiarities content and activity some components blood different age groups. Material methods . 30 healthy (donors) 56 uterine T1a-2N0M0, adenocarcinoma G1–G3 were divided into subgroups according age: reproductive, perimenopause menopause. ELISA urokinase (u-PA), receptor...
Purpose of the study . To evaluate role chronic chlamydial infection in genesis proliferative processes female genital area. Materials and methods The involved 267 women aged from 27 to 43 years. Depending on severity pathological process tract presence Chlamydia trachomatis infection, 6 groups were distinguished: 1st — 30 somatically healthy without pathologies reproductive system; 2nd 3rd those with inflammatory organs non-chlamydial (36) nature (38); 4th 5th pelvic (50) (58); 6th patients...
Background. Recently, studies have been conducted all over the world to study role of immune checkpoints in pathogenesis chronic lymphocytic leukemia (CLL) and possibility their use as prognostic markers. Of greatest interest are PD-1 (programmed cell death-1) LAG-3 protein (lymphocyte-activation gene 3). Aim. To features (CD279) (CD223) expression on blood B-cells CLL patients early markers for predicting hematological response therapy. Materials methods. The 30 with stage C according Binet...
Purpose of the study . To expression immunophenotypic marker molecules on B-lymphocytes patients with chronic lymphocytic leukemia at stages immunochemotherapy while monitoring minimal residual disease. Patients and methods 20 CLL were examined, who in period 2019–2022 underwent 6 courses (ICT) RB/FCR mode National Medical Research Centre for Oncology, Rostov-on-Don. Before, after 3, ICT, bone marrow immunophenotyping was performed by flow cytometry. The data is evaluated Statistica 13.0....
e17024 Background: The purpose of the study was to assess nitric oxide-derived peroxynitrite (P) and nitrosylhemoglobin (N) in prognosis evaluation effectiveness treatment patients with recurrent cervical cancer (CC). Methods: Levels (ONOO−) at λ = 302 nm 545 were studied by spectrofluorimetric method. data compared results CC standard CAP regimen chemotherapy. on tumor regression analyzed according initial (before chemotherapy) levels P N. control group included 26 women similar age without...
Представлены результаты исследования состояния гормонального статуса опухолевой и
e17505 Background: The purpose of the study was to determine VEGF-A expression in patients with cervical cancer assess its prognostic value. Methods: included 82 (23-70 years, median age 50.5±1.3 years) who underwent surgery for (T1aNоMo – 23 patients, T1bNоMo 42, T2aNоMo 17). VEGF-А determined blood serum before and after (Elisa, Chem Well, USA). results were compared clinical morphological data. control group 18 healthy women similar distribution. Results: Levels controls did not exceed...
The aim of this work was to assess the significance investigating clinical and laboratory parameters for diagnosing acute monocytic leukemia in children on basis a case. article demonstrates specific features differentiating AML M5a from other forms myeloid leukemia. According results hematological, morphological cytofluorimetric studies blood bone marrow samples, diagnosis established. phenotypic characteristics blast cells hampered an form. However, comprehensive analysis expressed CD...
Purpose of the study . Analysis possibility using presepsin in early diagnosis sepsis cancer patients after extensive surgical interventions for tumors thoraco-abdominal localization. Materials and methods The included 27 people: 10 healthy individuals (control) 17 who received treatment at National Medical Research Center Oncology malignant neoplasms In blood all patients, studies markers were performed: (P-SEP), highly sensitive CRP (hsCRP) (PATHFAST, Japan), procalcitonin (PCT),...
ОЦЕНКА ЭФФЕКТИВНОСТИ ОСТЕОМОДЕЛИРУЮЩЕЙ ТЕРАПИИ У БОЛЬНЫХ С ГОРМОНАЛЬНО-ЗАВИСИМЫМ РАКОМ МОЛОЧНОЙ ЖЕЛЕЗЫКит О
Cancer is one of the leading causes death and disability worldwide. Timely diagnosis introduction new effective treatments, including intensive radiation chemotherapy regimens, have significantly improved survival forecasts in recent years. At same time, use these types treatment increases risk complications, which includes chemotoxic cardiopathies. In this regard, timely detection complications from cardiovascular system patients receiving courses combination with surgical methods...
Prostate cancer is one of the most common malignancies in men. Early detection prostate largely determined by widely used specific antigen (PSA) blood test. However, as a diagnostic and prognostic test cancer, PSA has limited specificity, sensitivity leads to hyper or underdiagnosis, which, turn, can lead excessive treatment. There fore, it very important develop markers that be determine at an early stage development, assess possible progression disease prescribe optimal therapy....
e19500 Background: The purpose of the study was to assess clinical significance level and type secreted paraprotein in blood serum patients with multiple myeloma. Methods: Concentration (PP) were studied by capillary electrophoresis (Helena Bioscience V8, UK) 25 aged 47-76 years myeloma (MM) before during polychemotherapy (PCT). Results: Monoclonal PP detected 22 (88%), while secretion absent 3 patients, along noted decrease gamma globulin levels presence plasma cells aberrant...
We present a description of the difficulties in diagnosing acute megakaryoblastic leukemia child with Down syndrome aggravated by multiple comorbidities. In this case, comprehensive assessment clinical data, results an automatic complete blood count detailed interpretation entire range parameters, as well morphological and immunophenotypic bone marrow examination using extended panel monoclonal antibodies played key role diagnosis.